公开(公告)号：US20200289514A1

公开(公告)日：2020-09-17

申请号：US15775060

申请日：2016-11-11

Applicant: Novartis AG

Inventor： Karen KAMMERTOENS ,  Jean QUANCARD ,  Achim SCHLAPBACH ,  Oliver SIMIC ,  Marina TINTELNOT-BLOMLEY ,  Grahame WOOLLAM

IPC: A61K31/519 ,  A61K45/06 ,  C07D487/04

Abstract: The present invention describes new pyrazolo-pyrimidine derivatives which are generally interacting with MALT1 proteolytic and/or autoproteolytic activity, and in particular which may inhibit said activity. The present invention further describes the synthesis of said new pyrazolo-pyrimidine derivatives, their use as a medicament, especially by interacting with MALT1 proteolytic and/or autoproteolytic activity.

公开(公告)号：US20170320864A1

公开(公告)日：2017-11-09

申请号：US15385147

申请日：2016-12-20

Applicant: NOVARTIS AG

Inventor： Sangamesh BADIGER ,  Murali CHEBROLU ,  Konstanze HURTH ,  Sebastien JACQUIER ,  Rainer Martin LUEOEND ,  Rainer MACHAUER ,  Heinrich RUEEGER ,  Marina TINTELNOT-BLOMLEY ,  Siem Jacob VEENSTRA ,  Markus VOEGTLE

IPC: C07D413/14 ,  A61K31/5377 ,  C07D487/04 ,  C07D471/04 ,  C07B59/00

CPC classification number: C07D413/14 ,  A61K31/5377 ,  C07B59/002 ,  C07B2200/05 ,  C07D471/04 ,  C07D487/04 ,  A61K2300/00

Abstract: The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, combinations thereof, and their use as medicaments, particularly for the treatment of Alzheimer's Disease or diabetes via inhibition of BACE-1 or BACE-2.