公开(公告)号：US20230085472A1

公开(公告)日：2023-03-16

申请号：US17645071

申请日：2021-12-20

Applicant: Novartis AG

Inventor： David CARCACHE ,  Florian GRUBER ,  Danilo GUERINI ,  Martin GUNZENHAUSER ,  Richard HENG ,  Francesca PERRUCCIO ,  Oliver SIMIC ,  Carsten SPANKA

IPC: C07D401/14 ,  A61K45/06 ,  A61K31/4196 ,  A61K31/5377 ,  A61K31/454

Abstract: The present disclosure relates to a compound of Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, or tautomer thereof, wherein R1 through R8 are as defined herein, and methods of making and using the same.

公开(公告)号：US20240051954A1

公开(公告)日：2024-02-15

申请号：US18257318

申请日：2021-12-20

Applicant: NOVARTIS AG

Inventor： David CARCACHE ,  Florian GRUBER ,  Danilo GUERINI ,  Martin GUNZENHAUSER ,  Richard HENG ,  Francesca PERRUCCIO ,  Oliver SIMIC ,  Carsten SPANKA

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: The present disclosure relates to a compound of Formula (I): (I), or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, or tautomer thereof, wherein Ring A, and R1 through R4 are as defined herein, and methods of making and using the same.