公开(公告)号：US20230085472A1

公开(公告)日：2023-03-16

申请号：US17645071

申请日：2021-12-20

Applicant: Novartis AG

Inventor： David CARCACHE ,  Florian GRUBER ,  Danilo GUERINI ,  Martin GUNZENHAUSER ,  Richard HENG ,  Francesca PERRUCCIO ,  Oliver SIMIC ,  Carsten SPANKA

IPC: C07D401/14 ,  A61K45/06 ,  A61K31/4196 ,  A61K31/5377 ,  A61K31/454

Abstract: The present disclosure relates to a compound of Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, or tautomer thereof, wherein R1 through R8 are as defined herein, and methods of making and using the same.

公开(公告)号：US20190248784A1

公开(公告)日：2019-08-15

申请号：US16156447

申请日：2018-10-10

Applicant: NOVARTIS AG

Inventor： Juergen REINHARDT ,  Niko SCHMIEDEBERG ,  Carsten SPANKA

IPC: C07D471/04 ,  C07D495/14 ,  C07D471/14 ,  A61K45/06 ,  A61K31/4375 ,  A61K31/444 ,  C07D471/16 ,  A61K31/4745

CPC classification number: C07D471/04 ,  A61K31/4375 ,  A61K31/444 ,  A61K31/4745 ,  A61K45/06 ,  C07D471/14 ,  C07D471/16 ,  C07D495/14 ,  A61K2300/00

Abstract: The invention relates to compound of the formula (I′) or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to its use as medicament and to medicaments comprising it.

公开(公告)号：US20170266189A1

公开(公告)日：2017-09-21

申请号：US15478778

申请日：2017-04-04

Applicant: NOVARTIS AG

Inventor： Edgar JACOBY ,  Juergen REINHARDT ,  Niko SCHMIEDEBERG ,  Carsten SPANKA

IPC: A61K31/519 ,  C07D471/14 ,  C07D471/04

CPC classification number: A61K31/519 ,  C07D471/04 ,  C07D471/14

Abstract: The invention relates to compound of the formula (I); or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to its use as medicament and to medicaments comprising it.

公开(公告)号：US20240051954A1

公开(公告)日：2024-02-15

申请号：US18257318

申请日：2021-12-20

Applicant: NOVARTIS AG

Inventor： David CARCACHE ,  Florian GRUBER ,  Danilo GUERINI ,  Martin GUNZENHAUSER ,  Richard HENG ,  Francesca PERRUCCIO ,  Oliver SIMIC ,  Carsten SPANKA

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: The present disclosure relates to a compound of Formula (I): (I), or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, or tautomer thereof, wherein Ring A, and R1 through R4 are as defined herein, and methods of making and using the same.