公开(公告)号：US20210177824A1

公开(公告)日：2021-06-17

申请号：US16761779

申请日：2018-11-08

Applicant: NOVARTIS AG

Inventor： Carlo Castagnoli ,  Andreas Fisch ,  Mathilde Lorscheider ,  Manjali Laxman Neharkar ,  Bernd Ulrich Riebesehl

IPC: A61K31/4525 ,  A61K9/08 ,  A61K47/10 ,  A61K47/20 ,  A61K47/32 ,  A61K45/06 ,  A61K9/00

Abstract: The present invention relates to a pharmaceutical composition comprising an aqueous suspension of: (i) crystalline N-(3,4-dichlorophenyl)-3-(pyridin-4-yl)-7-oxabicyclo[2.2.1]heptane-2-carboxamide or a pharmaceutically acceptable salt thereof; and (ii) a surfactant comprising a water-soluble co-polymer characterized by >5% solubility in water at 25° C. The compositions provide extended release of N-(3,4-dichlorophenyl)-3-(pyridin-4-yl)-7-oxabicyclo[2.2.1] heptane-2-carboxamide, and are suitable for intra-articular injection to a joint of a patient suffering from arthritis, joint injury or cartilage injury.