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公开(公告)号:US20210187033A1
公开(公告)日:2021-06-24
申请号:US17092107
申请日:2020-11-06
Applicant: NOVARTIS AG
Inventor: Anthony Edward Boitano , Michael Cooke , Shifeng Pan , Peter G. Schultz , John Edward Tellew , Yongqin Wan , Xing Wang
IPC: A61K35/28 , A61K38/00 , C07D487/04 , C12N5/0789 , C07D473/34 , C07D473/16 , C07D495/04 , A61K9/00 , A61K31/52
Abstract: The present invention relates to compounds and compositions for expanding the number of CD34+ cells for transplantation. The invention further relates to a cell population comprising expanded hematopoietic stem cells (HSCs) and its use in autologous or allogeneic transplantation for the treatment of patients with inherited immunodeficient and autoimmune diseases and diverse hematopoietic disorders to reconstitute the hematopoietic cell lineages and immune system defense.
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公开(公告)号:US20170239296A1
公开(公告)日:2017-08-24
申请号:US15409292
申请日:2017-01-18
Applicant: NOVARTIS AG
Inventor: Anthony E. Boitano , Michael Cooke , Shifeng Pan , Peter G. Schultz , John Tellew , Yongqin Wan , Xing Wang
IPC: A61K35/28 , A61K9/00 , C12N5/0789 , A61K31/52
CPC classification number: A61K35/28 , A61K9/0019 , A61K31/52 , A61K38/00 , A61K2035/124 , C07D473/16 , C07D473/34 , C07D487/04 , C07D495/04 , C12N5/0647 , C12N2501/38 , C12N2501/60
Abstract: The present invention relates to compounds and compositions for expanding the number of CD34+ cells for transplantation. The invention further relates to a cell population comprising expanded hematopoietic stem cells (HSCs) and its use in autologous or allogeneic transplantation for the treatment of patients with inherited immunodeficient and autoimmune diseases and diverse hematopoietic disorders to reconstitute the hematopoietic cell lineages and immune system defense.
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