公开(公告)号：US11160797B2

公开(公告)日：2021-11-02

申请号：US16766114

申请日：2017-11-24

Applicant: NOVARTIS AG

Inventor： Luca Arista ,  Sylvie Chamoin ,  Pier Luca D'Alessandro ,  Mika Lindvall ,  Dimitrios Lizos ,  Nikolaus Johannes Stiefl ,  Sylvie Teixeira-Fouchard ,  Thomas Ullrich ,  Sven Weiler

IPC: A61K31/444 ,  A61P19/08 ,  A61K31/497 ,  A61K31/501 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D417/14 ,  C07D471/04

Abstract: The invention relates to a compound of Formula I or a pharmaceutically acceptable salt thereof, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.