公开(公告)号：US20210251996A1

公开(公告)日：2021-08-19

申请号：US16981208

申请日：2019-03-25

Applicant: NOVARTIS AG

Inventor： Luca Arista ,  Christina Hebach ,  Gregory John Hollingworth ,  Philipp Holzer ,  Patricia Imbach-Weese ,  Rainer Machauer ,  Niko Schmiedeberg ,  Anna Vulpetti ,  Thomas Zoller

IPC: A61K31/519 ,  C07D519/00 ,  C07D487/04 ,  A61P35/00

Abstract: The invention relates to compounds of the formula (I) or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to use of the compounds in the treatment of disease.

公开(公告)号：US11541056B2

公开(公告)日：2023-01-03

申请号：US16981208

申请日：2019-03-25

Applicant: NOVARTIS AG

Inventor： Luca Arista ,  Christina Hebach ,  Gregory John Hollingworth ,  Philipp Holzer ,  Patricia Imbach-Weese ,  Rainer Machauer ,  Niko Schmiedeberg ,  Anna Vulpetti ,  Thomas Zoller

IPC: C07D519/00 ,  C07D487/04 ,  A61K31/519 ,  A61P35/00

Abstract: The invention relates to compounds of the formula (I) or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to use of the compounds in the treatment of disease.

公开(公告)号：US11613543B2

公开(公告)日：2023-03-28

申请号：US16981059

申请日：2019-03-22

Applicant: NOVARTIS AG

Inventor： Luca Arista ,  Christina Hebach ,  Gregory John Hollingworth ,  Philipp Holzer ,  Patricia Imbach-Weese ,  Julien Lorber ,  Rainer Machauer ,  Niko Schmiedeberg ,  Anna Vulpetti ,  Thomas Zoller

IPC: A61K31/519 ,  C07D487/04 ,  C07D519/00 ,  A61K45/06

Abstract: The invention relates to compounds of the formula (I) (I) or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to use of the compounds in the treatment of disease.

公开(公告)号：US11160797B2

公开(公告)日：2021-11-02

申请号：US16766114

申请日：2017-11-24

Applicant: NOVARTIS AG

Inventor： Luca Arista ,  Sylvie Chamoin ,  Pier Luca D'Alessandro ,  Mika Lindvall ,  Dimitrios Lizos ,  Nikolaus Johannes Stiefl ,  Sylvie Teixeira-Fouchard ,  Thomas Ullrich ,  Sven Weiler

IPC: A61K31/444 ,  A61P19/08 ,  A61K31/497 ,  A61K31/501 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D417/14 ,  C07D471/04

Abstract: The invention relates to a compound of Formula I or a pharmaceutically acceptable salt thereof, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US10947218B2

公开(公告)日：2021-03-16

申请号：US16884666

申请日：2020-05-27

Applicant: NOVARTIS AG

Inventor： Luca Arista ,  Sreehari Babu ,  Jianwei Bian ,  Kai Cui ,  Michael Patrick Dillon ,  Rene Lattmann ,  Jialiang Li ,  Lv Liao ,  Dimitrios Lizos ,  Rita Ramos ,  Nikolaus Johannes Stiefl ,  Thomas Ullrich ,  Peggy Usselmann ,  Xiaoyang Wang ,  Liladhar Murlidhar Waykole ,  Sven Weiler ,  Yubo Zhang ,  Yizong Zhou ,  Tingying Zhu

IPC: A61K31/4427 ,  C07D405/14 ,  C07D401/14 ,  C07D401/10 ,  C07D401/12 ,  C07D409/14 ,  C07D213/82 ,  C07D411/14 ,  C07D491/107 ,  A61P19/00 ,  C07D417/00 ,  C07D413/00 ,  C07D419/00 ,  A61P19/08 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D491/20

Abstract: The invention relates to a compound of formula (I) in free form or in pharmaceutically acceptable salt form to pharmaceutical compositions comprising said compound and to the use of said compound in the treatment of heterotopic ossification and fibrodysplasia ossificans progressiva.

公开(公告)号：US20210002285A1

公开(公告)日：2021-01-07

申请号：US16981059

申请日：2019-03-22

Applicant: NOVARTIS AG

Inventor： Luca Arista ,  Christina Hebach ,  Gregory John Hollingworth ,  Philipp Holzer ,  Patricia Imbach-Weese ,  Julien Lorber ,  Rainer Machauer ,  Niko Schmiedeberg ,  Anna Vulpetti ,  Thomas Zoller

IPC: C07D487/04 ,  C07D519/00

Abstract: The invention relates to compounds of the formula (I) (I) or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to use of the compounds in the treatment of disease.

公开(公告)号：US10710980B2

公开(公告)日：2020-07-14

申请号：US16318250

申请日：2017-07-18

Applicant: NOVARTIS AG

Inventor： Luca Arista ,  Sreehari Babu ,  Jianwei Bian ,  Kai Cui ,  Michael Patrick Dillon ,  Rene Lattmann ,  Jialiang Li ,  Lv Liao ,  Dimitrios Lizos ,  Rita Ramos ,  Nikolaus Johannes Stiefl ,  Thomas Ullrich ,  Peggy Usselmann ,  Xiaoyang Wang ,  Liladhar Murlidhar Waykole ,  Sven Weiler ,  Yubo Zhang ,  Yizong Zhou ,  Tingying Zhu

IPC: C07D405/14 ,  C07D401/14 ,  C07D401/10 ,  C07D401/12 ,  C07D409/14 ,  C07D213/82 ,  C07D411/14 ,  C07D491/107 ,  A61P19/00 ,  C07D417/00 ,  C07D413/00 ,  C07D419/00 ,  A61P19/08 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D491/20

Abstract: The invention relates to a compound of formula (I) in free form or in pharmaceutically acceptable salt form (I) to pharmaceutical compositions comprising said compound and to the use of said compound in the treatment of heterotopic ossification and fibrodysplasia ossificans progressiva.