公开(公告)号：US20170088546A1

公开(公告)日：2017-03-30

申请号：US15311086

申请日：2015-05-14

Applicant: NOVARTIS AG

Inventor： Luca ARISTA ,  Rene BEERLI ,  Simona COTESTA ,  Pier Luca D'ALESSANDRO ,  Rene LATTMANN ,  Robert Alexander PULZ ,  Thomas J. TROXLER

IPC: C07D413/12 ,  A61K31/423 ,  A61K31/424 ,  C07D498/04

CPC classification number: C07D413/12 ,  A61K31/423 ,  A61K31/424 ,  C07D498/04

Abstract: The present invention provides a compound of formula I The compounds of formula I demonstrate properties as Smurf-1 inhibitors and are thus useful in the treatment of a range of disorders, particularly pulmonary arterial hypertension.