公开(公告)号：US20230398117A1

公开(公告)日：2023-12-14

申请号：US18060796

申请日：2022-12-01

Applicant: Novartis AG

Inventor： Luca ARISTA ,  Christina HEBACH ,  Gregory John HOLLINGWORTH ,  Philipp HOLZER ,  Patricia IMBACH-WEESE ,  Rainer MACHAUER ,  Niko SCHMIEDEBERG ,  Anna VULPETTI ,  Thomas ZOLLER

IPC: A61K31/519 ,  A61P35/00 ,  C07D487/04 ,  C07D519/00

CPC classification number: A61K31/519 ,  A61P35/00 ,  C07D487/04 ,  C07D519/00

Abstract: The invention relates to compounds of the formula (I)




or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to use of the compounds in the treatment of disease.

公开(公告)号：US20240158399A1

公开(公告)日：2024-05-16

申请号：US18169361

申请日：2023-02-15

Applicant: Novartis AG

Inventor： Luca ARISTA ,  Christina HEBACH ,  Gregory John HOLLINGWORTH ,  Philipp HOLZER ,  Patricia IMBACH-WEESE ,  Julien LORBER ,  Rainer MACHAUER ,  Niko SCHMIEDEBERG ,  Anna VULPETTI ,  Thomas ZOLLER

IPC: C07D487/04 ,  C07D519/00

CPC classification number: C07D487/04 ,  C07D519/00 ,  A61K45/06

Abstract: The invention relates to compounds of the formula (I)






or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to use of the compounds in the treatment of disease.

公开(公告)号：US20170088546A1

公开(公告)日：2017-03-30

申请号：US15311086

申请日：2015-05-14

Applicant: NOVARTIS AG

Inventor： Luca ARISTA ,  Rene BEERLI ,  Simona COTESTA ,  Pier Luca D'ALESSANDRO ,  Rene LATTMANN ,  Robert Alexander PULZ ,  Thomas J. TROXLER

IPC: C07D413/12 ,  A61K31/423 ,  A61K31/424 ,  C07D498/04

CPC classification number: C07D413/12 ,  A61K31/423 ,  A61K31/424 ,  C07D498/04

Abstract: The present invention provides a compound of formula I The compounds of formula I demonstrate properties as Smurf-1 inhibitors and are thus useful in the treatment of a range of disorders, particularly pulmonary arterial hypertension.

公开(公告)号：US20210155606A1

公开(公告)日：2021-05-27

申请号：US17170690

申请日：2021-02-08

Applicant: NOVARTIS AG

Inventor： Luca ARISTA ,  Sreehari BABU ,  Jianwei BIAN ,  Kai CUI ,  Michael Patrick DILLON ,  Rene LATTMANN ,  Jialiang LI ,  Lv LIAO ,  Dimitrios LIZOS ,  Rita RAMOS ,  Nikolaus Johannes STIEFL ,  Thomas ULLRICH ,  Peggy USSELMANN ,  Xiaoyang WANG ,  Liladhar Murlidhar WAYKOLE ,  Sven WEILER ,  Yubo ZHANG ,  Yizong ZHOU ,  Tingying ZHU

IPC: C07D401/14 ,  C07D405/14 ,  C07D401/10 ,  C07D401/12 ,  C07D409/14 ,  C07D213/82 ,  C07D411/14 ,  C07D491/107 ,  A61P19/00 ,  C07D417/00 ,  C07D413/00 ,  C07D419/00 ,  A61P19/08 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D491/20

Abstract: The invention relates to a compound of formula (1) in free form or in pharmaceutically acceptable salt form to pharmaceutical compositions comprising said compound and to the use of said compound in the treatment of heterotopic ossification and fibrodysplasia ossificans progressiva.

公开(公告)号：US20220387602A1

公开(公告)日：2022-12-08

申请号：US17642285

申请日：2020-09-14

Applicant: NOVARTIS AG

Inventor： Luca ARISTA ,  Valerie BROENNIMANN ,  Pier Luca D'ALESSANDRO ,  Lionel DOUMAMPOUOM-METOUL ,  Marie-Line GOUDE ,  Christina HEBACH ,  Gregory John HOLLINGWORTH ,  Ingrid Karen Jennifer JEULIN ,  Louise Clare KIRMAN ,  Julien LORBER ,  Fupeng MA ,  Anna VULPETTI ,  Ken YAMADA ,  Thomas ZOLLER

IPC: A61K47/55 ,  A61K47/54

Abstract: Described herein are bifunctional degrader compounds, their various targets, their preparation, pharmaceutical compositions comprising them, and their use in the treatment of conditions, diseases, and disorders mediated by various target proteins.

公开(公告)号：US20200299265A1

公开(公告)日：2020-09-24

申请号：US16884666

申请日：2020-05-27

Applicant: NOVARTIS AG

Inventor： Luca ARISTA ,  Sreehari BABU ,  Jianwei BIAN ,  Kai CUI ,  Michael Patrick DILLON ,  Rene LATTMANN ,  Jialiang LI ,  Lv LIAO ,  Dimitrios LIZOS ,  Rita RAMOS ,  Nikolaus Johannes STIEFL ,  Thomas ULLRICH ,  Peggy USSELMANN ,  Xiaoyang WANG ,  Liladhar Murlidhar WAYKOLE ,  Sven WEILER ,  Yubo ZHANG ,  Yizong ZHOU ,  Tingying ZHU

IPC: C07D401/14 ,  C07D405/14 ,  C07D401/10 ,  C07D401/12 ,  C07D409/14 ,  C07D213/82 ,  C07D411/14 ,  C07D491/107 ,  A61P19/00 ,  C07D417/00 ,  C07D413/00 ,  C07D419/00 ,  A61P19/08 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D491/20

Abstract: The invention relates to a compound of formula (I) in free form or in pharmaceutically acceptable salt form to pharmaceutical compositions comprising said compound and to the use of said compound in the treatment of heterotopic ossification and fibrodysplasia ossificans progressiva.

公开(公告)号：US20190161474A1

公开(公告)日：2019-05-30

申请号：US16318250

申请日：2017-07-18

Applicant: NOVARTIS AG

Inventor： Luca ARISTA ,  Sreehari BABU ,  Jianwei BIAN ,  Kai CUI ,  Michael Patrick DILLON ,  Rene LATTMANN ,  Jialiang LI ,  Lv LIAO ,  Dimitrios LIZOS ,  Rita RAMOS ,  Nikolaus Johannes STIEFL ,  Thomas ULLRICH ,  Peggy USSELMANN ,  Xiaoyang WANG ,  Liladhar Murlidhar WAYKOLE ,  Sven WEILER ,  Yubo ZHANG ,  Yizong ZHOU ,  Tingying ZHU

IPC: C07D401/14 ,  C07D401/10 ,  C07D401/12 ,  C07D491/20 ,  C07D405/14 ,  C07D409/14 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  A61P19/08

Abstract: The invention relates to a compound of formula (I) in free form or in pharmaceutically acceptable salt form (I) to pharmaceutical compositions comprising said compound and to the use of said compound in the treatment of heterotopic ossification and fibrodysplasia ossificans progressiva.