公开(公告)号：US20240052042A1

公开(公告)日：2024-02-15

申请号：US18267403

申请日：2021-12-13

Applicant: NOVARTIS AG

Inventor： Yuichiro ADACHI ,  Jennifer R. ALLPORT-ANDERSON ,  Shaun R. COUGHLIN ,  John Louis DIENER ,  Lars GADTKE ,  Felix HARTLEPP ,  Tiancen HU ,  Alexander Wolfgang KOCH ,  Kathrin LADETZKI-BAEHS ,  Michael John ROMANOWSKI ,  Cesare RUSSO ,  Xenia Karola WEZLER ,  Xiaoling XIE

IPC: C07K16/28 ,  A61K45/06 ,  A61P9/12

CPC classification number: C07K16/2863 ,  A61K45/06 ,  A61P9/12

Abstract: The present disclosure relates to use of reversal agents which specifically bind to anti-Natriuretic Peptide Receptor 1 (NPR1) antibodies or antigen binding fragments thereof, and reverse one or more effects of the anti-NPR1 antibody or antigen binding fragments thereof (e.g., hypotensive effects).