公开(公告)号：US20230365674A1

公开(公告)日：2023-11-16

申请号：US18193581

申请日：2023-03-30

Applicant: NOVARTIS AG

Inventor： John Louis DIENER ,  Lars GADTKE ,  Felix HARTLEPP ,  Tiancen HU ,  Kathrin LADETZKI-BAEHS ,  Michael John ROMANOWSKI ,  Cesare RUSSO ,  Xenia WEZLER ,  Xiaoling XIE

IPC: C07K16/28 ,  A61P9/00 ,  A61K39/395 ,  A61P13/12

CPC classification number: C07K16/28 ,  A61K39/3955 ,  A61P9/00 ,  A61P13/12 ,  C07K16/2869 ,  A61K45/06

Abstract: This disclosure relates to anti-Natriuretic Peptide Receptor 1 (NPR1) antibodies including agonist antibodies which are able to activate the NPR1 receptor, pharmaceutical compositions comprising the same, and methods of treatment comprising the same.

公开(公告)号：US20170362326A1

公开(公告)日：2017-12-21

申请号：US15073141

申请日：2016-03-17

Applicant: NOVARTIS AG

Inventor： Feng CONG ,  Seth ETTENBERG ,  Felix HARTLEPP ,  Ingo Markus KLAGGE

IPC: C07K16/28 ,  A61K39/00

CPC classification number: C07K16/2863 ,  A61K2039/505 ,  A61P35/00 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/35 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/00

Abstract: The present invention relates to antibodies targeting LRP6 and compositions and methods of use thereof.

公开(公告)号：US20240052042A1

公开(公告)日：2024-02-15

申请号：US18267403

申请日：2021-12-13

Applicant: NOVARTIS AG

Inventor： Yuichiro ADACHI ,  Jennifer R. ALLPORT-ANDERSON ,  Shaun R. COUGHLIN ,  John Louis DIENER ,  Lars GADTKE ,  Felix HARTLEPP ,  Tiancen HU ,  Alexander Wolfgang KOCH ,  Kathrin LADETZKI-BAEHS ,  Michael John ROMANOWSKI ,  Cesare RUSSO ,  Xenia Karola WEZLER ,  Xiaoling XIE

IPC: C07K16/28 ,  A61K45/06 ,  A61P9/12

CPC classification number: C07K16/2863 ,  A61K45/06 ,  A61P9/12

Abstract: The present disclosure relates to use of reversal agents which specifically bind to anti-Natriuretic Peptide Receptor 1 (NPR1) antibodies or antigen binding fragments thereof, and reverse one or more effects of the anti-NPR1 antibody or antigen binding fragments thereof (e.g., hypotensive effects).

公开(公告)号：US20220356242A1

公开(公告)日：2022-11-10

申请号：US17348949

申请日：2021-06-16

Applicant: NOVARTIS AG

Inventor： John Louis DIENER ,  Lars GADTKE ,  Felix HARTLEPP ,  Tiancen HU ,  Kathrin LADETZKI-BAEHS ,  Michael John ROMANOWSKI ,  Cesare RUSSO ,  Xenia WEZLER ,  Xiaoling XIE

IPC: C07K16/28 ,  A61P9/00 ,  A61K39/395 ,  A61P13/12

Abstract: This disclosure relates to anti-Natriuretic Peptide Receptor 1 (NPR1) antibodies including agonist antibodies which are able to activate the NPR1 receptor, pharmaceutical compositions comprising the same, and methods of treatment comprising the same.