公开(公告)号：US10011599B2

公开(公告)日：2018-07-03

申请号：US15460633

申请日：2017-03-16

Applicant: NOVARTIS AG

Inventor： Mark Gary Bock ,  Henrik Moebitz ,  Sunil Kumar Panigrahi ,  Ramulu Poddutoori ,  Susanta Samajdar

IPC: C07D471/04 ,  A61K31/4745 ,  A61K31/506 ,  A61K31/513 ,  A61K31/497 ,  A61K31/53

CPC classification number: C07D471/04 ,  A61K31/437 ,  A61K31/4745 ,  A61K31/497 ,  A61K31/506 ,  A61K31/513 ,  A61K31/53 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention relates to compounds of formula I: in which n, R1, R2, R3a, R4 and R5 are defined in the Summary of the Invention; capable of inhibiting the activity of MEK. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of hyperproliferative diseases like cancer.

公开(公告)号：US09629836B2

公开(公告)日：2017-04-25

申请号：US14940717

申请日：2015-11-13

Applicant: NOVARTIS AG

Inventor： Mark Gary Bock ,  Henrik Moebitz ,  Sunil Kumar Panigrahi ,  Ramulu Poddutoori ,  Susanta Samajdar

IPC: C07D471/04 ,  A61K31/437 ,  A61K31/4745 ,  A61K31/506 ,  A61K31/513 ,  A61K31/53 ,  A61K45/06

CPC classification number: C07D471/04 ,  A61K31/437 ,  A61K31/4745 ,  A61K31/497 ,  A61K31/506 ,  A61K31/513 ,  A61K31/53 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention relates to compounds of formula I: in which n, R1, R2, R3a, R4 and R5 are defined in the Summary of the Invention; capable of inhibiting the activity of MEK. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of hyperproliferative diseases like cancer.