专利检索 ap:("NOVARTIS AG") AND inv:"Thomas ZOLLER" 第 1 页

1.

发明公开
3-hydroxy-N-(3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)pyrrolidine-1-carboxamide Derivatives 审中-公开

公开(公告)号：US20230398117A1

公开(公告)日：2023-12-14

申请号：US18060796

申请日：2022-12-01

申请人： Novartis AG

发明人： Luca ARISTA , Christina HEBACH , Gregory John HOLLINGWORTH , Philipp HOLZER , Patricia IMBACH-WEESE , Rainer MACHAUER , Niko SCHMIEDEBERG , Anna VULPETTI , Thomas ZOLLER

IPC分类号： A61K31/519 , A61P35/00 , C07D487/04 , C07D519/00

CPC分类号： A61K31/519 , A61P35/00 , C07D487/04 , C07D519/00

摘要： The invention relates to compounds of the formula (I)

or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to use of the compounds in the treatment of disease.

2.

发明公开
N-(3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)benzamide Derivatives 审中-公开

公开(公告)号：US20240158399A1

公开(公告)日：2024-05-16

申请号：US18169361

申请日：2023-02-15

申请人： Novartis AG

发明人： Luca ARISTA , Christina HEBACH , Gregory John HOLLINGWORTH , Philipp HOLZER , Patricia IMBACH-WEESE , Julien LORBER , Rainer MACHAUER , Niko SCHMIEDEBERG , Anna VULPETTI , Thomas ZOLLER

IPC分类号： C07D487/04 , C07D519/00

CPC分类号： C07D487/04 , C07D519/00 , A61K45/06

摘要： The invention relates to compounds of the formula (I)

or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to use of the compounds in the treatment of disease.

3.

发明申请
BIFUNCTIONAL DEGRADERS AND THEIR METHODS OF USE 有权

公开(公告)号：US20220387602A1

公开(公告)日：2022-12-08

申请号：US17642285

申请日：2020-09-14

申请人： NOVARTIS AG

发明人： Luca ARISTA , Valerie BROENNIMANN , Pier Luca D'ALESSANDRO , Lionel DOUMAMPOUOM-METOUL , Marie-Line GOUDE , Christina HEBACH , Gregory John HOLLINGWORTH , Ingrid Karen Jennifer JEULIN , Louise Clare KIRMAN , Julien LORBER , Fupeng MA , Anna VULPETTI , Ken YAMADA , Thomas ZOLLER

IPC分类号： A61K47/55 , A61K47/54

摘要： Described herein are bifunctional degrader compounds, their various targets, their preparation, pharmaceutical compositions comprising them, and their use in the treatment of conditions, diseases, and disorders mediated by various target proteins.

4.

发明申请
BRD9 BIFUNCTIONAL DEGRADERS AND THEIR METHODS OF USE 有权

公开(公告)号：US20220315578A1

公开(公告)日：2022-10-06

申请号：US17020114

申请日：2020-09-14

申请人： NOVARTIS AG

发明人： Xin CHEN , Marie-Line GOUDE , Edmund Martin HARRINGTON , Gregory John HOLLINGWORTH , Julien LORBER , Martin SENDZIK , Anna VULPETTI , Thomas ZOLLER

IPC分类号： C07D471/04 , C07D401/14

摘要： The disclosure provides BRD9 bifunctional compounds of Formula (A), (BF-I), (BF-II), (BF-III), (BF-IIIa), (BF-IIIb), (BF-IV), (BF-IVa), (BF-IVb), (BF-I′), (BF-II′), (BF-III′), (BF-IV′), or (BF-V′), or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, to their preparation, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases and disorders mediated by a bromodomain-containing protein, such as bromodomain-containing protein 9 (BRD9).