公开(公告)号：US20240269304A1

公开(公告)日：2024-08-15

申请号：US18038435

申请日：2021-11-23

申请人： Novartis AG ,  Les Laboratoires Servier

发明人： Matthew T. Burger ,  Zhuoliang Chen ,  Joseph Anthony D'Alessio ,  Eric McNeill ,  Katsumasa Nakajima ,  Richard Vaughan Newcombe ,  Mark G. Palermo ,  Bing Yu ,  Qiang Zhang ,  Frédéric Colland ,  James Edward Paul Davidson ,  Lea Delacour ,  Patrice Desos ,  Olivier Geneste ,  Vesela Kostova ,  Andras Kotschy ,  Ana Leticia Maragno ,  James Brooke Murray ,  Tibor Novak ,  Jérôme Benoit Starck

IPC分类号： A61K47/68 ,  A61P35/00

CPC分类号： A61K47/6803 ,  A61K47/6849 ,  A61K47/6851 ,  A61K47/6889 ,  A61P35/00

摘要： Antibody-drug conjugates that bind to human oncology targets are disclosed. The antibody-drug conjugates comprise a Bcl-xL inhibitor drug moiety. The disclosure farther relates to methods and compositions for use in the treatment of cancers by administering the antibody-drug conjugates provided herein. Linker-drug conjugates comprising Bcl-xL inhibitor drug moiety and methods of making same are also disclosed.

公开(公告)号：US20230092679A1

公开(公告)日：2023-03-23

申请号：US17613006

申请日：2020-05-19

申请人： NOVARTIS AG ,  LES LABORATOIRES SERVIER

发明人： Matthew T. Burger ,  Maia Chanrion ,  Frédéric Colland ,  Marton Csekei ,  Lea Delacour ,  Patrice Desos ,  Olivier Geneste ,  Jean-Michel Henlin ,  Vesela Kostova ,  Andras Kotschy ,  Ana Leticia Maragno ,  Eric McNeill ,  Mark G. Palermo ,  Francesca Rocchetti ,  Jérôme Starck ,  Bing Yu ,  Qiang Zhang ,  Ágnes Proszenyák ,  Szabolcs Sipos ,  Zhuoliang Chen ,  Katsumasa Nakajima ,  Joseph Anthony D'Alessio

IPC分类号： A61K47/68 ,  A61K47/65 ,  A61K31/505 ,  A61P35/00

摘要： Antibody-drug conjugates that bind to human oncology targets are disclosed. The antibody-drug conjugates comprise an Mcl-1 inhibitor drug moiety. The disclosure further relates to methods and compositions for use in the treatment of cancers by administering the antibody-drug conjugates provided herein. Linker-drug conjugates comprising an Mcl-1 inhibitor drug moiety and methods of making same are also disclosed.

公开(公告)号：US20230081720A1

公开(公告)日：2023-03-16

申请号：US17613020

申请日：2020-05-19

申请人： NOVARTIS AG ,  LES LABORATOIRES SERVIER

发明人： Matthew T. Burger ,  Maia Chanrion ,  Frédéric Colland ,  Marton Csekei ,  Lea Delacour ,  Patrice Desos ,  Olivier Geneste ,  Jean-Michel Henlin ,  Vesela Kostova ,  Andras Kotschy ,  Ana Leticia Maragno ,  Eric McNeill ,  Mark G. Palermo ,  Francesca Rocchetti ,  Jérôme Starck ,  Bing Yu ,  Qiang Zhang ,  Ágnes Proszenyák ,  Szabolcs Sipos ,  Zhuoliang Chen ,  Katsumasa Nakajima ,  Joseph Anthony D'Alessio ,  John William Blankenship

IPC分类号： A61K47/68

摘要： Anti-CD74 antibody-drug conjugates are disclosed. The anti-CD74 antibody-drug conjugates comprise an Mcl-1 inhibitor drug moiety and an anti-CD74 antibody or antigen-binding fragment thereof that binds an antigen target, e.g., an antigen expressed on a tumor or other cancer cell. The disclosure further relates to methods and compositions for use in the treatment of cancers by administering the antibody-drug conjugates provided herein. Linker-drug conjugates comprising an Mcl-1 inhibitor drug moiety and methods of making same are also disclosed.