Amatoxin derivatives and conjugates thereof as inhibitors of RNA polymerase

    公开(公告)号:US10604547B2

    公开(公告)日:2020-03-31

    申请号:US16574500

    申请日:2019-09-18

    申请人: NOVARTIS AG

    IPC分类号: C07K7/64 A61P35/00 A61K47/68

    摘要: The invention disclosed herein relates to cytotoxic cyclic peptides of Formula (A), methods of inhibiting RNA polymerase with such cyclic peptides, immunoconjugates comprising such cyclic peptides (i.e Antibody Drug Conjugates), pharmaceutical compositions comprising such cyclic peptides immunoconjugates, compositions comprising such cyclic peptides immunoconjugates with a therapeutic co-agent and methods of treatment using such cyclic peptides immunoconjugates: