公开(公告)号：US20220202897A1

公开(公告)日：2022-06-30

申请号：US17599211

申请日：2020-03-30

Applicant: NOVMETAPHARMA CO., LTD. ,  SEOUL NATIONAL UNIVERSITY HOSPITAL ,  SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION

Inventor： Hoe Yune JUNG ,  Heon Jong LEE ,  Jong Su JEON ,  Do Hyun LEE ,  Yon Su KIM ,  Seung Hee YANG ,  Yong Chul KIM ,  Jong Joo MOON ,  Ji Eun KIM

IPC: A61K38/12 ,  A61P19/04 ,  A61P11/00 ,  A61P1/16

Abstract: A Cyclo (his-pro) (CHP) is useful for preventing, ameliorating, or treating fibrosis. A pharmaceutical composition containing CHP may be used for preventing or treating fibrosis. A health functional food composition containing CHP may be used for preventing or ameliorating fibrosis. An antifibrotic composition, a method of preventing, ameliorating, or treating fibrosis by using CHP, and/or a use of CHP in the manufacture of the pharmaceutical composition for preventing or treating fibrosis are disclosed.

公开(公告)号：US20220193179A1

公开(公告)日：2022-06-23

申请号：US17599118

申请日：2020-03-30

Applicant: NOVMETAPHARMA CO., LTD. ,  SEOUL NATIONAL UNIVERSITY HOSPITAL ,  SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION

Inventor： Hoe Yune JUNG ,  Do Hyun LEE ,  Heon Jong LEE ,  Yon Su KIM ,  Seung Hee YANG

IPC: A61K38/01 ,  A61P43/00 ,  A23L33/18

Abstract: A cyclo(His-Pro)(CHP) is useful for preventing, alleviating or treating peritoneal fibrosis. A pharmaceutical composition for preventing or treating peritoneal fibrosis, a dietary supplement composition for preventing or alleviating peritoneal fibrosis, and a peritoneal dialysis solution, which all contain CHP is disclosed. Also disclosed are a method for preventing or treating peritoneal fibrosis by using CHP, a peritoneal dialysis method using CHP, a use of CHP during the preparation of a pharmaceutical composition for preventing or treating peritoneal fibrosis, and/or a use of CHP in the preparation of a peritoneal dialysis solution.

公开(公告)号：US20220218793A1

公开(公告)日：2022-07-14

申请号：US17612038

申请日：2020-05-18

Applicant: NOVMETAPHARMA CO., LTD.

Inventor： Hoe Yune JUNG ,  Do Hyun LEE ,  Heon Jong LEE

IPC: A61K38/29 ,  A61P19/10

Abstract: A use of a cyclo(his-pro) (CHP) in combination with parathyroid hormone (PTH) and compositions containing the CHP in combination with PTH is disclosed. The combination of CHP and PTH is useful for preventing, improving, or treating a bone loss-related disease. Therefore, a method for treating, preventing, or improving bone loss-related disease in a subject, which includes administering the CHP in combination with PTH is disclosed. The PTH and CHP may be administered to the subject simultaneously, separately, or sequentially.

公开(公告)号：US20250161301A1

公开(公告)日：2025-05-22

申请号：US18954719

申请日：2024-11-21

Applicant: NOVMETAPHARMA CO., LTD

Inventor： Hoe Yune JUNG ,  Jongsu JEON ,  Do Hyun LEE ,  Seo Yeong BAEK ,  Shin Yu BAEK ,  Heon Jong LEE

IPC: A61K31/4985 ,  A61K33/30 ,  A61P3/04 ,  A61P3/10

Abstract: A composition for preventing, ameliorating or treating obesity and diabetes and its uses are disclosed. The composition includes zinc gluconate and cyclo-hispro (CHP) as active ingredients. More specifically, the composition includes the type of zinc salts and/or the content ratio of zinc components optimized for surprisingly significantly improved anti-obesity and anti-diabetic effects. A method of preventing, ameliorating or treating obesity and diabetes using the composition is also disclosed.

公开(公告)号：US20200338156A1

公开(公告)日：2020-10-29

申请号：US16764913

申请日：2018-11-20

Applicant: NovMetaPharma Co., Ltd.

Inventor： Hoe Yune JUNG ,  Heon Jong LEE ,  Do Hyun LEE

IPC: A61K38/12 ,  A61K35/52 ,  A61P19/10

Abstract: A composition containing cyclo-hispro (CHP) and its use in preventing, alleviating, or treating bone loss diseases are disclosed. The composition contains CHP or a CHP-containing prostate extract.