公开(公告)号：US3743660A

公开(公告)日：1973-07-03

申请号：US3743660D

申请日：1971-07-27

Applicant: NOVO TERAPEUTISK LABOR AS

Inventor： BORREVANG P ,  GUDDAL E

IPC: C07C20060101 ,  C07C169/08

CPC classification number: C07J75/00

Abstract: NOVEL AND PHARMACEUTICALLY ACTIVE STEROID COMPOUNDS OF THE ESTRANE SERIES HAVING THE GENERAL FORMULA I

3-(R1-O-),13-R2,17-(R3-O-SO2-R4-COO-),17-R5-ESTRA-1,3,5-

TRIENE

IN WHICH R1 IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN; ALKYL; CYCLOALKYL; AND HETEROCYCLOALKYL, R2 IS A LOWER ALKYL GROUP, R3 IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN; ALKYL; ARYLOXYALKYL; AND AN ALKALI METAL OR AN ALKALINE EARTH METAL ATOM, R4 IS ALKYLENE SUCH AS METHYLENE, ETHYLENE AND TRIMETHYLENE AND R5 IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND ETHINYL, AND AMINE SALTS OF THE ABOVE COMPOUNDS OF THE FORMULA I IN WHICH R3 IS HYDROGEN; AND METHODS FOR THEIR PREPARATION AS WELL AS PHARMACEUTICAL COMPOSITIONS COMPRISING THE PRESENT STEROID COMPOUDS AS AN ACTIVE INGREDIENT.