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公开(公告)号：US3743660A
公开(公告)日：1973-07-03
申请号：US3743660D
申请日：1971-07-27
Applicant: NOVO TERAPEUTISK LABOR AS
Inventor： BORREVANG P , GUDDAL E
IPC: C07C20060101 , C07C169/08
CPC classification number: C07J75/00
Abstract: NOVEL AND PHARMACEUTICALLY ACTIVE STEROID COMPOUNDS OF THE ESTRANE SERIES HAVING THE GENERAL FORMULA I
3-(R1-O-),13-R2,17-(R3-O-SO2-R4-COO-),17-R5-ESTRA-1,3,5-
TRIENE
IN WHICH R1 IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN; ALKYL; CYCLOALKYL; AND HETEROCYCLOALKYL, R2 IS A LOWER ALKYL GROUP, R3 IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN; ALKYL; ARYLOXYALKYL; AND AN ALKALI METAL OR AN ALKALINE EARTH METAL ATOM, R4 IS ALKYLENE SUCH AS METHYLENE, ETHYLENE AND TRIMETHYLENE AND R5 IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND ETHINYL, AND AMINE SALTS OF THE ABOVE COMPOUNDS OF THE FORMULA I IN WHICH R3 IS HYDROGEN; AND METHODS FOR THEIR PREPARATION AS WELL AS PHARMACEUTICAL COMPOSITIONS COMPRISING THE PRESENT STEROID COMPOUDS AS AN ACTIVE INGREDIENT.-
公开(公告)号：US3669843A
公开(公告)日：1972-06-13
申请号：US3669843D
申请日：1969-08-15
Applicant: NOVO TERAPEUTISK LABOR AS
Inventor： AUNSTRUP KNUD , MAHLER JORN LEO
CPC classification number: C12N9/0046 , Y10S435/832
Abstract: Production of the enzyme uricase by aerobic cultivation of a strain of Bacillus fastidiosus or a variant thereof.
Abstract translation: 通过需氧培养芽孢杆菌菌株或其变种产生酶尿苷酶。
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3.发明授权
公开(公告)号：US3058885A
公开(公告)日：1962-10-16
申请号：US73801158
申请日：1958-05-27
Applicant: NOVO TERAPEUTISK LABOR AS
Inventor： JORGEN SCHLICHTKRULL
IPC: A61K38/00 , C07K14/625
CPC classification number: C07K14/625 , A61K38/00
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4.发明授权Process for crystallization of insulin using freeze dried insulin as seeding material 失效使用冷冻干燥的胰岛素作为接种材料的胰岛素结晶过程
公开(公告)号：US2819999A
公开(公告)日：1958-01-14
申请号：US46854254
申请日：1954-11-12
Applicant: NOVO TERAPEUTISK LABOR AS
Inventor： JORGEN SCHLICHTKRULL , MERETE NORING INGER
IPC: A61K38/00 , C07K14/625
CPC classification number: C07K14/625 , A61K38/00
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5.发明授权Method of recovering broteolytic pancreas enzymes from mammalian pancreas glands subsequent to insulin removal 失效胰岛素去除后从哺乳动物胰腺中回收溶解性胰腺酶的方法
公开(公告)号：US2803585A
公开(公告)日：1957-08-20
申请号：US20932651
申请日：1951-01-03
Applicant: NOVO TERAPEUTISK LABOR AS
Inventor： EMIL FREDERIKSEN SVEND
IPC: C12N9/94
CPC classification number: C12N9/94 , Y10S435/803 , Y10S530/845
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Patent Agency Ranking6.发明授权Process of producing insulin crystals of substantially uniform size and compositions thereof 失效生产基本均匀尺寸的胰岛素晶体及其组合物的方法
公开(公告)号：US2799622A
公开(公告)日：1957-07-16
申请号：US46854154
申请日：1954-11-12
Applicant: NOVO TERAPEUTISK LABOR AS
Inventor： JPHIRGEN SCHLICHTKRULL , MERETE NPHIRING INGER
IPC: A61K38/00 , C07K14/625
CPC classification number: C07K14/625 , A61K38/00
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公开(公告)号：US3860619A
公开(公告)日：1975-01-14
申请号：US31197372
申请日：1972-12-04
Applicant: NOVO TERAPEUTISK LABOR AS
Inventor： CHRISTENSEN HALDOR , LUNDT BEHREN M FREIDRICH , GRONWALD FREDERICK CHRISTIAN , ANDERSEN WILLIAM
IPC: A61K31/64 , C07D307/79 , C07D311/58 , C07D5/40
CPC classification number: C07D307/79 , A61K31/64 , C07D311/58 , Y10S514/866
Abstract: The invention provides novel compounds of the formula:
AND SALTS THEREOF, IN WHICH R1 is n-butyl, cycloalkyl having five to eight ring carbon atoms, cyclohexenyl, 4methylcyclohexyl, 4,4-dimethylcyclohexyl, 4-methoxycyclohexyl, 2,5-endomethylenecyclohexyl or endoethylenecyclohexyl, R2 is hydrogen or methoxy, methyl, bromine or chlorine in position four or in position five, R3 is methyl or hydrogen, R4 and R5 are each hydrogen or methyl but not both methyl at the same time, or R4 and R5 may together form a bond completing a benzo(b)furan ring system. These compounds are useful in the oral treatment of maturityonset diabetis mellitus.Abstract translation: 本发明提供下式的新型化合物：
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公开(公告)号：US3860608A
公开(公告)日：1975-01-14
申请号：US30523872
申请日：1972-11-10
Applicant: NOVO TERAPEUTISK LABOR AS
Inventor： LUNDT BEHREND FRIEDRICH
IPC: C07D209/36 , C07D27/56
CPC classification number: C07D209/36
Abstract: This invention is concerned with novel and pharmaceutically active indole derivatives having the structure:
AND THE SALTS THEREOF WITH PHYSIOLOGICALLY ACCEPTABLE ACIDS, IN WHICH EACH OF X and Y is selected from the group consisting of hydrogen, chlorine, lower alkyl having 1 - 3 carbon atoms and lower alkoxy having 1 - 3 carbon atoms, R1 is selected from the group consisting of hydrogen, lower alkyl having 1 - 4 carbon atoms and benzyl, R2 is selected from the group consisting of hydrogen, lower alkyl having 1 - 4 carbon atoms, benzyl and phenyl, R3 represents lower alkyl having 1 - 3 carbon atoms, or the two groups R3 form together with the attached nitrogen atom a pyrrolidine or a piperidine ring, and A is an alkylene chain having 2 or 3 carbon atoms.-
9.发明授权Steroid compounds of the estrane, androstane, pregnane and 19-norpregnane series and the preparation thereof 失效ESTRANE的安非他酮类化合物，安地罗菌，PREGNANE和19-NORPREGNANE系列及其制备方法
公开(公告)号：US3673224A
公开(公告)日：1972-06-27
申请号：US3673224D
申请日：1969-12-16
Applicant: NOVO TERAPEUTISK LABOR AS
Inventor： BORREVANG POUL , FAARUP PETER
IPC: C07J41/00 , C07C169/34
CPC classification number: C07J41/0005
Abstract: Novel and therapeutically useful steroid compounds of the estrane, androstane, pregnane or 19-norpregnane series and having the partial ring A configuration: AS WELL AS PROCESSES FOR THE PREPARATION OF THESE STEROID COMPOUNDS.
Abstract translation: 雌激素，雌二醇，孕烷或19-去甲孕烷系列的新型和治疗上有用的类固醇化合物，并具有部分环A构型：
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10.发明授权17-spiro-3'-diaziridine steroids of the androstane and estrane series 失效安第斯山脉和埃斯班系列的17-SPIRO-3'-二氮唑类固醇
公开(公告)号：US3538084A
公开(公告)日：1970-11-03
申请号：US3538084D
申请日：1968-06-19
Applicant: NOVO TERAPEUTISK LABOR AS
Inventor： BORREVANG POUL , FAARUP PETER , HJORT JORGEN
IPC: C07J21/00 , C07J41/00 , C07J43/00 , C07C169/10 , C07C173/10
CPC classification number: C07J21/006 , C07J41/0005 , C07J43/006
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