公开(公告)号：US3860608A

公开(公告)日：1975-01-14

申请号：US30523872

申请日：1972-11-10

Applicant: NOVO TERAPEUTISK LABOR AS

Inventor： LUNDT BEHREND FRIEDRICH

IPC: C07D209/36 ,  C07D27/56

CPC classification number: C07D209/36

Abstract: This invention is concerned with novel and pharmaceutically active indole derivatives having the structure:

AND THE SALTS THEREOF WITH PHYSIOLOGICALLY ACCEPTABLE ACIDS, IN WHICH EACH OF X and Y is selected from the group consisting of hydrogen, chlorine, lower alkyl having 1 - 3 carbon atoms and lower alkoxy having 1 - 3 carbon atoms, R1 is selected from the group consisting of hydrogen, lower alkyl having 1 - 4 carbon atoms and benzyl, R2 is selected from the group consisting of hydrogen, lower alkyl having 1 - 4 carbon atoms, benzyl and phenyl, R3 represents lower alkyl having 1 - 3 carbon atoms, or the two groups R3 form together with the attached nitrogen atom a pyrrolidine or a piperidine ring, and A is an alkylene chain having 2 or 3 carbon atoms.

公开(公告)号：US3860609A

公开(公告)日：1975-01-14

申请号：US30523972

申请日：1972-11-10

Applicant: NOVO TERAPEUTISK LABOR AS

Inventor： LUNDT BEHREND FRIEDRICH

IPC: C07D209/36 ,  C07D27/56

CPC classification number: C07D209/36

Abstract: This invention is concerned with novel and pharmaceutically active indole derivatives having the structure:

AND THE SALTS THEREOF WITH PHYSIOLOGICALLY ACCEPTABLE ACIDS, IN WHICH EACH OF X and Y is selected from the group consisting of hydrogen, hydroxy, lower alkyl having 1-3 carbon atoms and lower alkoxy having 1-3 carbon atoms, R1 is selected from the group consisting of hydrogen, lower alkyl having 1-4 carbon atoms and benzyl, R2 is selected from the group consisting of hydrogen, lower alkyl having 1-4 carbon atoms, benzyl and phenyl, R3 is selected from the group consisting of hydrogen, lower alkyl having 1-8 carbon atoms, cycloalkyl having 5 or 6 carbon atoms, benzyl and 2-phenylethyl, and A is a straight or branched alkylene chain containing from 2 to 4 carbon atoms.

Abstract translation: 本发明涉及具有以下结构的新型和药学活性的吲哚衍生物：