公开(公告)号：US20230113829A1

公开(公告)日：2023-04-13

申请号：US17959584

申请日：2022-10-04

Applicant: NUTRITION ACT. CO.,LTD. ,  UNIVERSITY OF TSUKUBA

Inventor： HIROKO ISODA ,  SHINJI KONDO ,  FARHANA FERDOUSI ,  MASAHITO ISHIKAWA ,  YOUKO WATANABE ,  KEN YAMAUCHI ,  MIKI YOKOZAWA

IPC: A61K36/63 ,  A61K31/7048 ,  A61K8/9789 ,  A61Q19/00 ,  A61P7/06 ,  C12N5/0789 ,  A23L33/105

Abstract: The invention provides an HIF-1 activator for treatment, prevention, alleviation, improvement or recovery from diseases or symptoms associated with reduced HIF-1 activity, as well as a pharmaceutical composition, cosmetic and food composition comprising the activator. Provided is an HIF-1 activator comprising olive leaf extract. Also provided is an HIF-1 activator which is for maintaining the undifferentiated state of stem cells via HIF-1 activation and/or improving dysdifferentiation of stem cells.