公开(公告)号：US11940510B2

公开(公告)日：2024-03-26

申请号：US17995232

申请日：2021-03-31

申请人： NVISION IMAGING TECHNOLOGIES GMBH ,  UNIVERSITÄT ULM

发明人： Ilai Schwartz ,  Michael Keim ,  Martin Plenio ,  Benedikt Tratzmiller

IPC分类号： G01R33/28 ,  A61K49/10 ,  C07C67/14 ,  C07C67/293 ,  C07C69/716 ,  C07F7/08 ,  G01R33/46 ,  G01R33/44

CPC分类号： G01R33/282 ,  A61K49/10 ,  C07C67/14 ,  C07C67/293 ,  C07C69/716 ,  C07F7/081 ,  C07F7/083 ,  G01R33/4608 ,  C07B2200/05 ,  G01R33/445

摘要： A method for preparing an NMR material, comprising generating parahydrogen in gas or liquid form at a first location; transporting the parahydrogen away from the first location; mixing a precursor compound including a metabolite component with a catalyst for hydrogenation; hydrogenating the precursor compound using the parahydrogen; transferring polarization in the precursor compound to a nuclear spin of the metabolite component; cleaving a side arm of the precursor compound in a chemical reaction, with the metabolite molecule being one of the products of the reaction; separating the metabolite molecule from the catalyst for hydrogenation and other products of the reaction; and generating metabolite molecules for use in an MRI scanner by extracting a sample of the metabolite molecule having at least 5% polarization.