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    PARAHYDROGEN HYPERPOLARIZATION MEMBRANE REACTOR
    5.
    发明公开
    PARAHYDROGEN HYPERPOLARIZATION MEMBRANE REACTOR 审中-公开

    公开(公告)号：US20230152398A1

    公开(公告)日：2023-05-18

    申请号：US17916703

    申请日：2021-04-07

    Applicant: North Carolina State University

    Inventor： Thomas THEIS ,  Milad ABOLHASANI ,  Patrick TOMHON ,  Sören LEHMKUHL ,  Suyong HAN

    IPC: G01R33/28 ,  G01R33/46

    CPC classification number: G01R33/282 ,  G01R33/46

    Abstract: In one aspect, the disclosure relates to a compact membrane reactor for parahydrogen induced hyperpolarization, the reactor including an inner tube constructed of a semipermeable membrane, an outer tube surrounding the inner tube, and a means for controlling the magnetic field surrounding the outer tube. In some aspects, multiple compact membrane reactors can be arranged in parallel. In other aspects, the compact membrane reactor is equipped with a mechanism for magnetic field control. Also disclosed are fluid handling systems and sample preparation systems comprising the compact membrane reactors disclosed herein. The compact membrane reactor can be operated in a batch mode, a stopped-flow mode, or a continuous flow mode and can be configured to work with existing NMR spectrometers and MRI instruments.

    Microwave resonator with distributed bragg reflector (=DBR)
    6.
    发明授权
    Microwave resonator with distributed bragg reflector (=DBR) 有权

    公开(公告)号：US10036787B2

    公开(公告)日：2018-07-31

    申请号：US14905968

    申请日：2014-07-09

    Applicant: BRUKER BIOSPIN GMBH

    Inventor： Alexander Krahn ,  Frank Engelke

    IPC: G01R33/34 ,  G01R33/28 ,  G01R33/345 ,  G01R33/62 ,  G01N24/12

    CPC classification number: G01R33/34 ,  G01N24/12 ,  G01R33/282 ,  G01R33/345 ,  G01R33/62

    Abstract: An NMR (nuclear magnetic resonance) probe head has a microwave resonator with at least two elements which are reflective in the microwave range, at least one of which is focusing. The reflective elements at least partly delimit a resonance volume of the microwave resonator. At least one of the reflective elements is a DBR (“Distributed Bragg Reflector”), and the NMR probe head has at least one NMR coil integrated into the DBR. The NMR detection coil can thereby be positioned particularly near to the sample and the distortions of the static field by resonator components are reduced, such that the detection sensitivity and the spectral resolution of the experiment are significantly improved.

    DNP apparatus
    9.
    发明授权
    DNP apparatus 有权

    公开(公告)号：US09739862B2

    公开(公告)日：2017-08-22

    申请号：US14489502

    申请日：2014-09-18

    Applicant: BRUKER BIOSPIN AG

    Inventor： Dirk Wilhelm ,  Joost A. B. Lohman ,  Joerg Hinderer ,  Hannes Grubinger

    IPC: G01V3/00 ,  G01R33/56 ,  G01R33/28

    CPC classification number: G01R33/5605 ,  G01R33/28 ,  G01R33/282

    Abstract: A DNP apparatus includes a cryostat (7) having an opening (8) and a loading path for a sample (1), the loading path extending from the opening to a sample receptacle (29), with a cryomagnet and a microwave source (2) as well as a configuration for supplying microwave radiation from the microwave source to the sample, which comprises a microwave path extending directly to the sample. The microwave path extends spatially separately from the loading path and the configuration for supplying microwave radiation has at least one microwave feed-through passing through one or more walls of the cryostat. The microwave path is incident on the sample from a direction opposite to the loading path or from a sideward direction at right angles to or at an inclination with respect to the axis of the loading path. This leads to simple and efficient polarization of the electron spins in the sample.

    Creation of long-lived singlet states of gases and their use as inhalable MRI contrast agents
    10.
    发明授权
    Creation of long-lived singlet states of gases and their use as inhalable MRI contrast agents 有权

    公开(公告)号：US09702946B1

    公开(公告)日：2017-07-11

    申请号：US14689679

    申请日：2015-04-17

    Applicant: Konstantin Saprygin

    Inventor： Kirill V. Kovtunov ,  Igor V. Koptyug

    IPC: A61B5/055 ,  G01R33/28 ,  A61K49/10 ,  B01J19/08 ,  A61K49/04

    CPC classification number: G01R33/282 ,  A61K49/04 ,  A61K49/10 ,  A61K49/1815 ,  B01J19/087 ,  B01J2219/085 ,  G01R33/5601

    Abstract: Parahydrogen Induced Polarization was employed to prepare nuclear singlet state between methylene and methyl protons in propane gas. Low-field MRI preserves this singlet state with much longer TS=4.7±0.5 s. Spin-Lock Induced Crossing (SLIC) transforms singlet state in observable nuclear magnetization suitable for MRI with sub-millimeter and sub-second spatial and temporal resolution respectively with signal enhancement>10,000 times. Long-lived spin states created in hyperpolarized propane-d6 gas can be detected directly at 0.0475 T. This long lifetime and non-toxic nature of propane gas could be useful for bio-imaging applications including potentially pulmonary low-field MRI. The feasibility of high-resolution low-field 2D gradient-echo MRI was demonstrated with 0.88×0.88 mm2 spatial and ˜0.7 s temporal resolution respectively at 0.0475 T. Propane is a non-toxic gas, and therefore, these results enable low-cost high-resolution high-speed MRI of gases for imaging of lungs.

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