专利检索 ap:("Nabil G. Seidah" OR "Jean Davignon" OR "Geneviève Dubuc" OR "Lise Bernier" OR "Michel Tremblay") AND inv:"Jean Davignon" 第 1 页

1.

发明授权
Chimeric PCSK9 proteins, cells comprising same, and assays using same 有权
标题翻译：嵌合PCSK9蛋白，包含其的细胞和使用其的测定

公开(公告)号：US08187833B2

公开(公告)日：2012-05-29

申请号：US12300148

申请日：2007-05-08

申请人： Nabil G. Seidah , Jean Davignon , Geneviève Dubuc , Lise Bernier , Michel Tremblay

发明人： Nabil G. Seidah , Jean Davignon , Geneviève Dubuc , Lise Bernier , Michel Tremblay

IPC分类号： C12Q1/37 , G01N33/48

CPC分类号： G01N33/5008 , A61K38/00 , C07K16/40 , C07K2319/01 , C07K2319/03 , C12N9/6424

摘要： A chimera protein comprising in the following order: a signal peptide, a proprotein convertase subtilisin/kexin type 9 preproprotein (PCSK9) sequence consisting of amino acid residues at positions 35 to 696 of SEQ ID NO: 38, a transmembrane domain and a cytosolic domain, wherein said cytosolic (CT) domain comprises a sequence able to recycle the protein from the cellular membrane to endosomes.

摘要翻译： 包含以下顺序的嵌合体蛋白质：信号肽，由SEQ ID NO：38的35至696位的氨基酸残基组成的前蛋白转化酶枯草杆菌蛋白酶/ kexin 9型前蛋白（PCSK9）序列，跨膜结构域和胞质结构域，其中所述细胞溶质（CT）结构域包含能够将蛋白从细胞膜再循环到内体的序列。

2.

发明申请
CHIMERIC PCSK9 PROTEINS, CELLS COMPRISING SAME, AND ASSAYS USING SAME 有权
标题翻译： CHIMERIC PCSK9蛋白，包含其的细胞和使用相同的测定法

公开(公告)号：US20110003315A1

公开(公告)日：2011-01-06

申请号：US12300148

申请日：2007-05-08

申请人： Nabil G. Seidah , Jean Davignon , Geneviève Dubuc , Lise Bernier , Michel Tremblay

发明人： Nabil G. Seidah , Jean Davignon , Geneviève Dubuc , Lise Bernier , Michel Tremblay

IPC分类号： G01N33/567 , C12N9/50 , C12N5/10 , C12Q1/37

CPC分类号： G01N33/5008 , A61K38/00 , C07K16/40 , C07K2319/01 , C07K2319/03 , C12N9/6424

摘要： A chimera protein comprising in the following order: a signal peptide, a proprotein convertase subtilisin/kexin type 9 preproprotein (PCSK9) sequence consisting of amino acid residues at positions 35 to 696 of SEQ ID NO: 38, a transmembrane domain and a cytosolic domain, wherein said cytosolic (CT) domain comprises a sequence able to recycle the protein from the cellular membrane to endosomes.

摘要翻译： 包含以下顺序的嵌合体蛋白质：信号肽，由SEQ ID NO：38的35至696位的氨基酸残基组成的前蛋白转化酶枯草杆菌蛋白酶/ kexin 9型前蛋白（PCSK9）序列，跨膜结构域和胞质结构域，其中所述细胞溶质（CT）结构域包含能够将蛋白从细胞膜再循环到内体的序列。

3.

发明授权
Chimeric PCSK9 proteins, cells comprising same, and assays using same 有权

公开(公告)号：US08338568B2

公开(公告)日：2012-12-25

申请号：US13460029

申请日：2012-04-30

申请人： Nabil G. Seidah , Jean Davignon , Genevieve Dubuc , Lise Bernier , Michel Tremblay

发明人： Nabil G. Seidah , Jean Davignon , Genevieve Dubuc , Lise Bernier , Michel Tremblay

IPC分类号： C07K14/435

CPC分类号： G01N33/5008 , A61K38/00 , C07K16/40 , C07K2319/01 , C07K2319/03 , C12N9/6424

摘要： A chimera protein comprising in the following order: a signal peptide, a proprotein convertase subtilisin/kexin type 9 preproprotein (PCSK9) sequence consisting of amino acid residues at positions 35 to 696 of SEQ ID NO: 38, a transmembrane domain and a cytosolic domain, wherein said cytosolic (CT) domain comprises a sequence able to recycle the protein from the cellular membrane to endosomes.