公开(公告)号：US20060084056A1

公开(公告)日：2006-04-20

申请号：US10504287

申请日：2003-02-13

申请人： Nadia Harbeck ,  Manfred Schmitt ,  John Foekens ,  Ronald Kates

发明人： Nadia Harbeck ,  Manfred Schmitt ,  John Foekens ,  Ronald Kates

IPC分类号： C12Q1/68 ,  C12P19/34

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  G01N33/57415 ,  G01N2800/52 ,  Y02A90/26

摘要： The present invention relates to methods for determining a treatment regimen beyond surgical removal of tumor tissue for node negative or node positive breast cancer patient. The method comprises measuring the levels of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor-1 (PAI-1) in a subject, preferably a tumor; and, based upon the values, predicting the expected benefit including disease-free survival and/or overall survival for the patient without treatment (beyond the surgical removal of tumor tissue) or with a particular treatment and using that information to select a treatment regimen for the subject. High risk subject is identified by high levels of both uPA and PAI-1, high level of uPA and low level of PAI-1 or, low level of uPA and high level of PAI-1. Treatment options for high risk subjects include, but are not limited to, adjuvant CMF chemotherapy, adjuvant non-CMF chemotherapy, adjuvant endocrine therapy, adjuvant anthracyclin-containing chemotherapy, radiation therapy, and gene therapy. Treatment options for low risk subjects include, but are not limited to, no treatment, radiation, and adjuvant endocrine therapy.

摘要翻译： 本发明涉及用于确定除了手术切除淋巴结阴性或淋巴结阳性乳腺癌患者的肿瘤组织之外的治疗方案的方法。 该方法包括测量受试者，优选肿瘤中尿激酶型纤溶酶原激活物（uPA）和纤溶酶原激活物抑制剂-1（PAI-1）的水平; 并且基于这些值，预测未经治疗的患者（超过手术切除肿瘤组织）或特定治疗的患者的无病生存期和/或总生存期的预期益处，并且使用该信息来选择治疗方案 主题。 uPA和PAI-1水平高，uPA水平高，PAI-1水平低，uPA水平低，PAI-1水平高。 高风险患者的治疗方案包括但不限于辅助性CMF化疗，辅助性非CMF化疗，辅助内分泌治疗，含蒽环类化疗，放射治疗和基因治疗。 低风险患者的治疗方案包括但不限于治疗，放射和辅助内分泌治疗。

公开(公告)号：US06968327B1

公开(公告)日：2005-11-22

申请号：US10049650

申请日：2000-08-24

申请人： Ronald Kates ,  Nadia Harbeck ,  Manfred Schmitt

发明人： Ronald Kates ,  Nadia Harbeck ,  Manfred Schmitt

IPC分类号： A61B5/00 ,  G06F19/00 ,  G06N3/08 ,  G06E1/00 ,  G06E3/00 ,  G06F15/18 ,  G06G7/00

CPC分类号： G06N3/08 ,  A61B5/00 ,  A61B5/415 ,  A61B5/418 ,  A61B5/7267 ,  G06F19/00

摘要： A method for training a neural network in order to optimize the structure of the neural network includes identifying and eliminating synapses that have no significant influence on the curve of the risk function. First and second sending neurons are selected that are connected to the same receiving neuron by respective first and second synapses. It is assumed that there is a correlation of response signals from the first and second sending neurons to the same receiving neuron. The first synapse is interrupted and a weight of the second synapse is adapted in its place. The output signals of the changed neural network are compared with the output signals of the unchanged neural network. If the comparison result does not exceed a predetermined level, the first synapse is eliminated, thereby simplifying the structure of the neural network.

摘要翻译： 用于训练神经网络以优化神经网络的结构的方法包括识别和消除对风险函数的曲线没有显着影响的突触。 选择通过相应的第一和第二突触连接到相同接收神经元的第一和第二发送神经元。 假设存在来自第一和第二发送神经元到相同接收神经元的响应信号的相关性。 第一突触中断，第二突触的重量适应其位置。 将改变的神经网络的输出信号与不变神经网络的输出信号进行比较。 如果比较结果不超过预定水平，则消除第一突触，从而简化了神经网络的结构。

公开(公告)号：US20060248031A1

公开(公告)日：2006-11-02

申请号：US10520409

申请日：2003-07-03

申请人： Ronald Kates ,  Nadia Harbeck

发明人： Ronald Kates ,  Nadia Harbeck

IPC分类号： G06F15/18 ,  G06N3/02

CPC分类号： G16H50/20 ,  G06F19/00

摘要： The invention is directed to a method for training at least one learning-capable system comprising the steps of providing a predetermined training data set corresponding to a predetermined number of subjects comprising a predetermined input data set and a predetermined outcome data set, augmenting the input data set and/or the outcome data set, and training each learning-capable system using the augmented input data set and/or the augmented outcome data set.

摘要翻译： 本发明涉及用于训练至少一个学习能力系统的方法，包括以下步骤：提供对应于预定数量的对象的预定训练数据集，所述预定训练数据集包括预定输入数据集和预定结果数据集，增加输入数据 设置和/或结果数据集，并且使用增强输入数据集和/或增强结果数据集来训练每个具有学习能力的系统。

公开(公告)号：US08144032B2

公开(公告)日：2012-03-27

申请号：US12431334

申请日：2009-04-28

申请人： Klaus Bogenberger ,  Robert Hein ,  Ronald Kates

发明人： Klaus Bogenberger ,  Robert Hein ,  Ronald Kates

IPC分类号： G08G1/065

CPC分类号： G08G1/0129 ,  G08G1/0112

摘要： A method of checking the quality of traffic disturbance reporting processes records a total number of traffic disturbance reports generated by a traffic disturbance reporting process, which traffic disturbance reports each relate to at least one defined reporting time period and at least one defined reporting route segment, over a predefined analyzing time period and a predefined analyzing range. A number of reported conditions is formed from the total number of traffic disturbance reports, and a first statistical frequency distribution of the reported conditions is determined. A total number of reference observations are recorded, which each relate to at least one defined observation time period and at least one defined observation route segment, within the analyzing time period and within the analyzing range. A number of actual conditions is formed from the total number of reference observations and a second statistical frequency distribution of the actual conditions is determined. The second statistical frequency distribution is compared with the first statistical frequency distribution, and a quality indicator for the traffic disturbance reporting process is derived from the result of the comparison.

摘要翻译： 检查交通干扰报告过程的质量的方法记录由交通干扰报告过程产生的交通干扰报告的总数，每个交通干扰报告与至少一个定义的报告时间段和至少一个定义的报告路由段有关， 超过预定义的分析时间段和预定义的分析范围。 由交通干扰报告总数形成多个报告条件，确定报告条件的第一统计频率分布。 在分析时间段内和分析范围内记录参考观测值的总数，每个参考观测值与至少一个定义的观测时间段和至少一个定义的观测路线段相关。 从参考观测总数形成多个实际条件，确定实际条件的第二统计频率分布。 将第二统计频率分布与第一统计频率分布进行比较，并从比较结果中得出交通干扰报告过程的质量指标。

公开(公告)号：US20100073196A1

公开(公告)日：2010-03-25

申请号：US12431334

申请日：2009-04-28

申请人： Klaus Bogenberger ,  Robert Hein ,  Ronald Kates

发明人： Klaus Bogenberger ,  Robert Hein ,  Ronald Kates

IPC分类号： G08G1/065

CPC分类号： G08G1/0129 ,  G08G1/0112

摘要： A method of checking the quality of traffic disturbance reporting processes records a total number of traffic disturbance reports generated by a traffic disturbance reporting process, which traffic disturbance reports each relate to at least one defined reporting time period and at least one defined reporting route segment, over a predefined analyzing time period and a predefined analyzing range. A number of reported conditions is formed from the total number of traffic disturbance reports, and a first statistical frequency distribution of the reported conditions is determined. A total number of reference observations are recorded, which each relate to at least one defined observation time period and at least one defined observation route segment, within the analyzing time period and within the analyzing range. A number of actual conditions is formed from the total number of reference observations and a second statistical frequency distribution of the actual conditions is determined. The second statistical frequency distribution is compared with the first statistical frequency distribution, and a quality indicator for the traffic disturbance reporting process is derived from the result of the comparison.

摘要翻译： 检查交通干扰报告过程的质量的方法记录由交通干扰报告过程产生的交通干扰报告的总数，每个交通干扰报告与至少一个定义的报告时间段和至少一个定义的报告路由段有关， 超过预定义的分析时间段和预定义的分析范围。 由交通干扰报告总数形成多个报告条件，确定报告条件的第一统计频率分布。 在分析时间段内和分析范围内记录参考观测值的总数，每个参考观测值与至少一个定义的观测时间段和至少一个定义的观测路线段相关。 从参考观测总数形成多个实际条件，确定实际条件的第二统计频率分布。 将第二统计频率分布与第一统计频率分布进行比较，并从比较结果中得出交通干扰报告过程的质量指标。