公开(公告)号：US11214865B2

公开(公告)日：2022-01-04

申请号：US16912599

申请日：2020-06-25

Applicant: Nanexa AB

Inventor： Anders Johansson ,  Mårten Rooth ,  Joel Hellrup

IPC: C23C16/455 ,  A61J3/00 ,  B01J2/00 ,  B05B7/00 ,  C23C16/54 ,  C23C16/44 ,  B01J13/04 ,  A61K9/50

Abstract: A reactor for forming fully coated particles having a solid core, the reactor comprises a reactor vessel which is configured to receive particles, and a gas phase coating mechanism that is configured to selectively introduce pulses of gas phase materials that form a coating on the particles. The reactor also includes a sieve (16) that is located within the reactor vessel, and a forcing means that is configured to force the particles through the sieve (16) in use. The sieve is configured to deagglomerate any particle aggregates formed in the reactor vessel upon forcing of the particles by the forcing means through the sieve.

公开(公告)号：US20210169815A1

公开(公告)日：2021-06-10

申请号：US17111873

申请日：2020-12-04

Applicant: Nanexa AB

Inventor： Anders Johansson ,  Joel Hellrup ,  Mårten Rooth

IPC: A61K9/50 ,  A61K9/48 ,  A61K31/706 ,  A61K9/00 ,  A61K9/06 ,  C23C16/40 ,  C23C16/455 ,  C23C16/44

Abstract: There is provided a process for the preparation of composition in the form of a plurality of particles having a weight-, number-, and/or volume-based mean diameter that is between amount 10 nm and about 700 μm, which particles comprise: (a) solid cores, preferably comprising a biologically active agent; and (b) two or more sequentially applied, discrete layers, each of which comprises at least one separately applied coating material, and which two or more layers together surround, enclose and/or encapsulate said cores, which process comprises the sequential steps of: (1) applying an initial layer of at least one coating material to said solid cores by way of a gas phase deposition technique; (2) discharging the coated particles from the gas phase deposition reactor and subjecting the coated particles to agitation to disaggregate particle aggregates formed during step (1) by way of mechanical sieving technique; (3) reintroducing the disaggregated, coated particles from step (2) into the gas phase deposition reactor and applying a further layer of at least one coating material to the reintroduced particles; and (4) optionally repeating steps (2) and (3) one or more times to increase the total thickness of the at least one coating material that enclose(s) said solid core. The gas phase deposition technique is preferably atomic layer deposition. When the cores comprise biologically active agent, the compositions may provide for the delayed or sustained release of said active agent without a burst effect.