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公开(公告)号：US20190225668A1
公开(公告)日：2019-07-25
申请号：US16329739
申请日：2017-08-31
发明人： Qiuchuan Zhuang , Xiaohu Fan , Lei Yang , Pingyan Wang
IPC分类号： C07K14/705 , A61K35/17 , A61P35/02 , C12N15/62 , C12N15/86
摘要： The present invention relates to a human CD123-targeting chimeric receptor ligand, comprising an IL-3 molecule-based CD123 binding domain, a transmembrane region, and an intracellular signaling domain. The present invention provides a T cell modified by the human CD123-targeting chimeric receptor ligand and capable of specifically binding with CD123 on tumor cell surfaces, thereby having specific cytotoxicity on tumor cells. The present invention further relates to an application of the human CD123-targeting chimeric receptor ligand and an immune effector cell thereof in preparing an anti-tumor immunotherapy drug.
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公开(公告)号：US11564945B2
公开(公告)日：2023-01-31
申请号：US16474735
申请日：2017-12-29
发明人： Xiaohu Fan , Qiuchuan Zhuang , Pingyan Wang , Lei Yang , Xiujun Zheng , Jiaying Hao , Shaobo Liu
IPC分类号： A61K35/17 , C07K14/725 , C07K16/30 , C07K16/32 , C12N5/0735 , C12N5/0775 , C12N15/62 , A61K45/06
摘要： Disclosed herein is a novel chimeric antigen receptor and use thereof. The novel chimeric antigen receptor consists of a signal peptide, an antigen binding domain, a transmembrane region, and an intracellular signal domain, and comprises a 4-1BB signal peptide and/or a 4-1BB molecular transmembrane region. Nucleic acid sequences of various chimeric antigen receptors are separated and purified and provided is a chimeric antigen receptor and a CAR-T cell which are specific for a CD19 malignant tumor antigen. In the malignant tumor killing test of hematological cell lines, the ability of immune cells to target and recognize tumor cells is significantly enhanced, and the killing activity against tumor cells is also enhanced.
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公开(公告)号：US11827713B2
公开(公告)日：2023-11-28
申请号：US16626721
申请日：2018-06-27
发明人： Xiaohu Fan , Qiuchuan Zhuang , Lei Yang , Pingyan Wang , Qingyan Li
IPC分类号： C07K16/28 , A61P35/00 , A61K39/00 , C07K14/765
CPC分类号： C07K16/2896 , A61P35/00 , C07K14/765 , C07K16/2809 , C07K16/2878 , A61K2039/505 , C07K2317/24 , C07K2317/31 , C07K2317/565 , C07K2317/569 , C07K2317/622 , C07K2317/73 , C07K2317/92 , C07K2319/02 , C07K2319/30
摘要： Provided is a chimeric antibody immune cell engager comprising a target cell binding domain that specifically binds to an antigen on a target cell, and an immune effector cell binding domain comprising an antigen-binding fragment that specifically binds to an antigen on an immune effector cell. Also provided are pharmaceutical compositions, kits and methods of treatment.
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