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公开(公告)号:US20230136252A1
公开(公告)日:2023-05-04
申请号:US17910608
申请日:2021-03-12
发明人: Wang Zhang , Jintao Guo , Fengyuan TANG , Shuai Yang , Yuanyuan Peng , An Tang , Xiaojie Tu , Yunlei Liu , Shu Wu
IPC分类号: C07K16/30 , C12N5/0783 , C07K14/725 , C07K14/705 , C07K16/18 , C07K14/54 , A61K35/17 , A61K39/395 , A61K38/17 , A61K38/20 , A61K31/454 , A61P35/00 , A61P25/00 , A61P11/00
摘要: The present application provides GPC2-specific antibodies and antigen binding fragments thereof. A chimeric antigen receptor (CAR) that specifically binds glypican-2 (GPC2) comprising a GPC2-specific antibody, a transmembrane domain, and an intracellular signaling domain. T cells comprising the disclosed CAR constructs can be used for cancer immunotherapy.