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公开(公告)号：US20230405141A1
公开(公告)日：2023-12-21
申请号：US18040498
申请日：2021-08-13
申请人： CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. , NANJING SHUNXIN PHARMACEUTICALS CO., LTD. OF CHIATAI TIANQING PHARMACEUTICAL GROUP
发明人： Xiquan ZHANG , Tianxi CHEN , Weiwei FENG , Bing ZHANG , Xiaoqi TANG , Tongjie XU , Xiaojin WANG , Huace SHENG , Zhengping ZHANG , Hua WANG , Yong GAO
CPC分类号： A61K47/6855 , A61K47/545 , A61P35/00 , A61K47/6803 , A61K47/65
摘要： Provided is an antibody drug conjugate, specifically comprising a therapeutic antibody moiety, an intermediate linker moiety and a cytotoxic drug moiety which are linked. The therapeutic antibody moiety is an antibody against an HER2 target. The cytotoxic drug moiety is a camptothecin topoisomerase I inhibitor. The cytotoxic drug moiety or the linker-cytotoxic drug moiety is modified by means of deuterium substitution. The antibody drug conjugate can be used for the prevention or treatment of cancers.
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公开(公告)号：US20220289825A1
公开(公告)日：2022-09-15
申请号：US17637697
申请日：2020-08-28
申请人： Nanjing Shunxin Pharmaceuticals Co., Ltd., Of Chiatai Tianqing Pharmaceutical Group , Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
发明人： Wei ZHAO , Yingchun LI , Lianxiang XIE , Yamin LU , Haili LV , Xiuzhen DU , Tongjie XU , Yanju CHENG , Xiquan ZHANG
IPC分类号： C07K14/71 , A61P35/00 , C12N15/63 , C07K14/705
摘要： Provided are a fusion protein targeting PD-L1 and TGF-β and use thereof. The fusion protein is a fusion protein comprising an antibody or antigen-binding fragment that specifically binds to human PD-L1 and a human TGFβRII binding domain. Further provided are a polynucleotide encoding the fusion protein, a host cell containing the polynucleotide, and the use of the fusion protein in the preparation of an anti-tumor drug.
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公开(公告)号：US20230193292A1
公开(公告)日：2023-06-22
申请号：US18020578
申请日：2021-08-16
发明人： Zipeng ZHEN , Meijuan XIE , Xiuzhen DU , Yimin MA , Bing ZHANG , Tongjie XU , Xiquan ZHANG
摘要： A BCMA-binding immunoglobulin single variable structural domain and an antigen-binding molecule including an immunoglobulin single variable structural domain and an antigen-binding molecule, a nucleic acid encoding the above, a vector containing the nucleic acid, a cell containing the vector, and a pharmaceutical composition containing the above, as well as a therapeutic use thereof.
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公开(公告)号：US20230265181A1
公开(公告)日：2023-08-24
申请号：US18020584
申请日：2021-08-16
发明人： Zipeng ZHEN , Meijuan XIE , Xiuzhen DU , Yimin MA , Bing ZHANG , Tongjie XU , Xiquan ZHANG
CPC分类号： C07K16/241 , A61P35/00 , C07K2317/565 , C07K2317/24 , C07K2317/22 , C07K2317/52
摘要： An immunoglobulin single variable domain and antigen binding molecule binding BCMA, specifically comprising an immunoglobulin single variable domain and antigen binding molecule, a nucleic acid for encoding the binding molecule, a vector containing the nucleic acid, a cell containing the vector, and a pharmaceutical composition containing the above.
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