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1.发明申请公开(公告)号：US20200185053A1
公开(公告)日：2020-06-11
申请号：US16733013
申请日：2020-01-02
发明人： Shahrooz Rabizadeh , John Zachary Sanborn , Charles Joseph Vaske , Stephen Charles Benz , Patrick Soon-Shiong
摘要： Omics patient data are analyzed using sequences or diff objects of tumor and matched normal tissue to identify patient and disease specific mutations, using transcriptomic data to identify expression levels of the mutated genes, and pathway analysis based on the so obtained omic data to identify specific pathway characteristics for the diseased tissue. Most notably, many different tumors have shared pathway characteristics, and identification of a pathway characteristic of a tumor may thus indicate effective treatment options ordinarily not considered when tumor analysis is based on anatomical tumor type only.
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公开(公告)号：US20190018017A1
公开(公告)日：2019-01-17
申请号：US16060638
申请日：2016-12-11
发明人： Stephen Charles Benz , Todd Hembrough , Shahrooz Rabizadeh , John Zachary Sanborn , Charles Joseph Vaske , Fabiola Cecchi , Peter Fasching , Patrick Soon-Shiong
IPC分类号： G01N33/574 , A61K39/395 , C07K16/32 , A61K31/337
摘要： Various protein markers can be used as post-treatment relapse predictors in HER2 positive breast cancer. Notably, these markers appear to be independent of the size of the tumor, metastasis status, grade, and hormone receptor status. In addition, HER2 quantities were in large part not correlated with likelihood of relapse.
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公开(公告)号：US11361841B2
公开(公告)日：2022-06-14
申请号：US16073105
申请日：2017-02-10
发明人： Andrew Nguyen , John Zachary Sanborn , Stephen Charles Benz , Kayvan Niazi , Shahrooz Rabizadeh , Patrick Soon-Shiong , Charles Joseph Vaske
IPC分类号： G16B20/20 , G16B20/00 , A61K35/17 , A61K39/395 , A61K48/00 , C12Q1/6886 , A61K47/68 , A61K39/00 , A61K45/06
摘要： Systems and methods are presented that allow for selection of tumor neoepitopes that are filtered for various criteria. In particularly contemplated aspects, filtering includes a step in which the mutation leading to the neoepitope is ascertained as being located in a cancer driver gene.
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公开(公告)号：US20220165353A1
公开(公告)日：2022-05-26
申请号：US17591907
申请日：2022-02-03
发明人： Andrew Nguyen , John Zachary Sanborn , Charles Joseph Vaske , Shahrooz Rabizadeh , Kayvan Niazi , Patrick Soon-Shiong , Stephen Charles Benz
摘要： Methods for targeting a tumor antigen for immunotherapy based on HLA allele type and the mutations present in the tumor antigen are presented. A patient's HLA allele type and a tumor antigen derived from a mutation in cancer driver gene can be matched with a majority allele type having a minimum affinity to the same tumor antigen or with those of a plurality of patients with a history of cancer treatment. Upon matching, a cancer treatment against the tumor antigen can be selected and administered to the patient to achieve a desired effect.
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公开(公告)号：US11276479B2
公开(公告)日：2022-03-15
申请号：US16465997
申请日：2017-11-30
发明人： Andrew Nguyen , John Zachary Sanborn , Charles Joseph Vaske , Shahrooz Rabizadeh , Kayvan Niazi , Patrick Soon-Shiong , Stephen Charles Benz
摘要： Methods for targeting a tumor antigen for immunotherapy based on HLA allele type and the mutations present in the tumor antigen are presented. A patient's HLA allele type and a tumor antigen derived from a mutation in cancer driver gene can be matched with a majority allele type having a minimum affinity to the same tumor antigen or with those of a plurality of patients with a history of cancer treatment. Upon matching, a cancer treatment against the tumor antigen can be selected and administered to the patient to achieve a desired effect.
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6.发明申请公开(公告)号：US20190034582A1
公开(公告)日：2019-01-31
申请号：US16073105
申请日：2017-02-10
发明人： Andrew Nguyen , John Zachary Sanborn , Steven Charles Benz , Kayvan Niazi , Shahrooz Rabizadeh , Patrick Soon-Shiong , Charles Joseph Vaske
摘要： Systems and methods are presented that allow for selection of tumor neoepitopes that are filtered for various criteria. In particularly contemplated aspects, filtering includes a step in which the mutation leading to the neoepitope is ascertained as being located in a cancer driver gene.
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7.发明公开公开(公告)号：US20240126856A1
公开(公告)日：2024-04-18
申请号：US18396086
申请日：2023-12-26
CPC分类号： G06F21/32 , G06F21/602 , G06F21/645 , G16B50/40
摘要： Authentication tokens, systems, and methods are described. An illustrative method is disclosed to include receiving an electronic file including a digital image, receiving biometric information that is associated with a person, modifying the electronic file with the biometric information such that one or more pixels in the digital image are replaced with the biometric information, and storing the modified electronic file as a digital authentication token to be used in connection with authorized publications of original digital work.
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公开(公告)号：US11361844B2
公开(公告)日：2022-06-14
申请号：US16032421
申请日：2018-07-11
发明人： John Zachary Sanborn , Charles Joseph Vaske , Stephen Charles Benz , Shahrooz Rabizadeh , Nicole Hensley , Patrick Soon-Shiong
摘要： Contemplated systems and methods employ chimeric reference sequences that include a plurality of viral genome sequences to identify/quantify integration and co-amplification events. Most typically, the viral genome sequences are organized in the chimeric reference sequences as single chromosomes and the chimeric reference sequences are in BAM format.
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9.发明授权公开(公告)号：US11210383B2
公开(公告)日：2021-12-28
申请号：US17360066
申请日：2021-06-28
摘要： Authentication tokens, systems, and methods are described. An illustrative method is disclosed to include receiving an electronic file including a digital image, receiving biometric information that is associated with a person, modifying the electronic file with the biometric information such that one or more pixels in the digital image are replaced with the biometric information, and storing the modified electronic file as a digital authentication token to be used in connection with authorized publications of original digital work.
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10.发明授权公开(公告)号：US11048788B2
公开(公告)日：2021-06-29
申请号：US17111278
申请日：2020-12-03
摘要： Authentication tokens, systems, and methods are described. An illustrative method is disclosed to include receiving an electronic file including a digital image, receiving biometric information that is associated with a person, modifying the electronic file with the biometric information such that one or more pixels in the digital image are replaced with the biometric information, and storing the modified electronic file as a digital authentication token to be used in connection with authorized publications of original digital work.
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