公开(公告)号：US20240161877A1

公开(公告)日：2024-05-16

申请号：US17986655

申请日：2022-11-14

Applicant: Onai Inc.

Inventor： Guha Jayachandran ,  Patrick Grinaway ,  Shriphani Palakodety ,  Galana Gebisa

IPC: G16B50/40

CPC classification number: G16B50/40

Abstract: An apparatus for physically encrypting nucleic acid, wherein the apparatus include at least a computing device configured to receive a nucleic acid sample from a subject, input a secret defined by the subject, generate a nucleic acid codebook as a function of the secret, wherein the nucleic acid codebook include a code pattern and a plurality of nucleic acid keys correlates to a plurality of nucleic acid values, and at least a manufacturing device configured to encrypt a nucleic acid sample received from a subject as a function of the nucleic acid codebook, and output an encrypted nucleic acid sample.

公开(公告)号：US20240126856A1

公开(公告)日：2024-04-18

申请号：US18396086

申请日：2023-12-26

Applicant: Nant Holdings IP, LLC ,  ImmunityBio, Inc.

Inventor： Luna Witchey ,  John Zachary Sanborn ,  Patrick Soon-Shiong ,  Nicholas James Witchey

IPC: G06F21/32 ,  G06F21/60 ,  G06F21/64 ,  G16B50/40

CPC classification number: G06F21/32 ,  G06F21/602 ,  G06F21/645 ,  G16B50/40

Abstract: Authentication tokens, systems, and methods are described. An illustrative method is disclosed to include receiving an electronic file including a digital image, receiving biometric information that is associated with a person, modifying the electronic file with the biometric information such that one or more pixels in the digital image are replaced with the biometric information, and storing the modified electronic file as a digital authentication token to be used in connection with authorized publications of original digital work.

公开(公告)号：US20180262557A1

公开(公告)日：2018-09-13

申请号：US15910743

申请日：2018-03-02

Applicant: IntegenX Inc.

Inventor： Robert A. Schueren ,  David King ,  Chungsoo Charles Park ,  Arnaldo Barican ,  Charles David Troup

IPC: H04L29/08 ,  G01N27/447 ,  G06F19/24

CPC classification number: H04L67/10 ,  G01N27/447 ,  G01N27/44704 ,  G06F3/04817 ,  G16B40/00 ,  G16B50/40 ,  H04L67/18 ,  H04L67/22 ,  H04L67/306

Abstract: A command center includes at least one network communications interface configured for two-way communications with a plurality of sites remote from the command center and at least one display screen and user interface. Each of the plurality of sites includes at least one forensic field test device configured to identify individuals using DNA samples from the individuals. The display screen and user interface are configured to depict aspects of forensic field test devices of the plurality of sites, wherein the aspects include a site identifier for each of the forensic field test devices and one or more additional aspects.

公开(公告)号：US20230377692A1

公开(公告)日：2023-11-23

申请号：US18028222

申请日：2021-10-04

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Yee Him Cheung

IPC: G16B50/50 ,  G16B50/40 ,  G16B50/30 ,  G16B30/00 ,  G06F21/62

CPC classification number: G16B50/50 ,  G16B50/40 ,  G16B50/30 ,  G16B30/00 ,  G06F21/6245 ,  G06F2221/2101

Abstract: A method (100) for storing genomic data within a data structure comprising a file structure, comprising: (i) receiving (120) a genomic dataset comprising a plurality of fields or attributes of different data types; (ii) generating (130) an information metadata structure for the genomic dataset, comprising one or more of: information about an annotation table, including one or more user profiles and associated profile permission; analytics information configured to facilitate verification of data reproducibility; access history for the genomic dataset, configured to facilitate data traceability; and linkage information defining a relationship between the annotation table and one or more data objects; (ii) compressing (140) the genomic data and information metadata using a compression algorithm; and (iv) storing (150) the compressed genomic dataset and information metadata in a container data structure; wherein some or all of the annotation table is encrypted.

公开(公告)号：US20230325308A9

公开(公告)日：2023-10-12

申请号：US17514269

申请日：2021-10-29

Applicant: EUROPEAN MOLECULAR BIOLOGY LABORATORY

Inventor： Nick Goldman ,  John Birney

IPC: G06F12/02 ,  G16B50/40 ,  G16B50/50 ,  G16B30/00 ,  B82Y10/00 ,  G06N3/12

CPC classification number: G06F12/023 ,  G16B50/40 ,  G16B50/50 ,  G16B30/00 ,  B82Y10/00 ,  G06N3/123 ,  G06F2212/1032

Abstract: A method for storage of an item of information (210) is disclosed. The method comprises encoding bytes (720) in the item of information (210), and representing using a schema the encoded bytes by a DNA nucleotide to produce a DNA sequence (230). The DNA sequence (230) is broken into a plurality of overlapping DNA segments (240) and indexing information (250) added to the plurality of DNA segments. Finally, the plurality of DNA segments (240) is synthesized (790) and stored (795).

公开(公告)号：US20230253073A1

公开(公告)日：2023-08-10

申请号：US18301875

申请日：2023-04-17

Applicant: Applied Materials, Inc.

Inventor： Yun-Ching Chang ,  Dan Xie ,  Chloe Kim

IPC: G16B40/10 ,  G02B21/00 ,  G01N21/64 ,  C12Q1/6841 ,  G02B21/16 ,  G02B21/36 ,  G06T5/00 ,  G06T5/20 ,  G06T5/50 ,  G06T7/00 ,  G16B50/40 ,  G06V10/30 ,  G06V20/69 ,  G06V10/50 ,  G06V10/75

CPC classification number: G16B40/10 ,  C12Q1/6841 ,  G01N21/6428 ,  G01N21/6456 ,  G01N21/6458 ,  G02B21/16 ,  G02B21/0076 ,  G02B21/365 ,  G02B21/367 ,  G06T5/003 ,  G06T5/006 ,  G06T5/20 ,  G06T5/50 ,  G06T7/0012 ,  G06V10/30 ,  G06V10/507 ,  G06V10/758 ,  G06V20/69 ,  G06V20/698 ,  G16B50/40 ,  G01N2021/755 ,  G01N2021/6419 ,  G01N2021/6421 ,  G06T2207/10056 ,  G06T2207/10064 ,  G06T2207/30004 ,  G06T2207/30168

Abstract: A fluorescent in-situ hybridization imaging system includes a flow cell to contain a sample, a fluorescence microscope, and a control system. The fluorescence microscope includes a variable frequency excitation light source to illuminate the sample, a plurality of emission bandpass filters on a filter wheel, an actuator to rotate the filter wheel, and a camera positioned to receive fluorescently emitted light from the sample. The control system is configured to cause the variable frequency excitation light source to emit a light beam having a selected wavelength, cause the actuator to rotate the filter wheel to position a selected filter in a light path between the sample and the camera, obtain an image from the camera, and coordinate the variable frequency excitation light source and filter wheel such that the selected filter has an emission bandpass associated with emission by the fluorescent probes when excited by the selected wavelength.

公开(公告)号：US11657899B2

公开(公告)日：2023-05-23

申请号：US16650436

申请日：2018-09-26

Applicant: Université du Luxembourg

Inventor： Paulo Esteves-Veríssimo ,  Marcus Völp ,  Jérémie Decouchant ,  Maria Fernandes

IPC: G16B30/10 ,  G16H10/40 ,  G16B50/30 ,  G16B20/50 ,  G16B50/40 ,  G06F21/60 ,  G06F21/62 ,  H04L9/08

CPC classification number: G16B30/10 ,  G06F21/602 ,  G06F21/6245 ,  G16B20/50 ,  G16B50/30 ,  G16B50/40 ,  G16H10/40 ,  H04L9/0833

Abstract: Genomics information such as DNA, RNA and proteins carry a wealth of sensitive information, the exposure of which risks compromising the privacy and/or business interest of individuals and companies. An apparatus, a system and methods are disclosed for protecting sensitive genomic information either as it is produced by a sequencing machine or immediately therafter, then throughout the whole genomic workflow. Raw genomic data (“reads”) is detected and classified according to sensitivity. Reads are decomposed by excising the number and type of detected sensitive base or base pairs in less sensitive or insensitive parts of the read. The genomic workflow processes the excised information locally or in a distributed fashion, preferably within trusted execution environments for increased security.

公开(公告)号：US20240185021A1

公开(公告)日：2024-06-06

申请号：US18355206

申请日：2023-07-19

Applicant: Western Digital Technologies, Inc.

Inventor： Ran Zamir ,  Alexander Bazarsky ,  David Avraham

IPC: G06N3/00 ,  G16B50/30 ,  G16B50/40

CPC classification number: G06N3/002 ,  G16B50/30 ,  G16B50/40

Abstract: A computer-implemented method includes receiving an encoding table defining a plurality of mappings between input segments and encoded segments, where each encoded segment defines an ordered string of data representing a sequence of one or more deoxyribonucleic acid (DNA) nucleotide bases; identifying an input string of input data; segmenting the input string into a plurality of input tuples; for each input tuple, generate a plurality of encoded tuples by identifying an entry of the encoding table that has an input segment equal to the input tuple and adding an encoded tuple that includes an encoded segment; converting the plurality of encoded tuples into a DNA sequence string of DNA nucleotides by concatenating the plurality of encoded tuples in an order defined by the plurality of input tuples; and transmitting the DNA sequence string of DNA nucleotides to be used for synthesizing at least one DNA molecule.

公开(公告)号：US11892945B2

公开(公告)日：2024-02-06

申请号：US17514158

申请日：2021-10-29

Applicant: EUROPEAN MOLECULAR BIOLOGY LABORATORY

Inventor： Nick Goldman ,  John Birney

IPC: G06F12/02 ,  G16B50/40 ,  G16B50/50 ,  G16B30/00 ,  B82Y10/00 ,  G06N3/123 ,  G11C13/02

CPC classification number: G06F12/023 ,  B82Y10/00 ,  G06N3/123 ,  G11C13/02 ,  G16B30/00 ,  G16B50/40 ,  G16B50/50 ,  G06F2212/1032

Abstract: A method for storage of an item of information (210) is disclosed. The method comprises encoding bytes (720) in the item of information (210), and representing using a schema the encoded bytes by a DNA nucleotide to produce a DNA sequence (230). The DNA sequence (230) is broken into a plurality of overlapping DNA segments (240) and indexing information (250) added to the plurality of DNA segments. Finally, the plurality of DNA segments (240) is synthesized (790) and stored (795).

公开(公告)号：US11783916B2

公开(公告)日：2023-10-10

申请号：US17124353

申请日：2020-12-16

Applicant: Applied Materials, Inc.

Inventor： Yun-Ching Chang ,  Dan Xie ,  Chloe Kim

IPC: G06K9/00 ,  G16B40/10 ,  G02B21/00 ,  G01N21/64 ,  C12Q1/6841 ,  G02B21/16 ,  G02B21/36 ,  G06T5/00 ,  G06T5/20 ,  G06T5/50 ,  G06T7/00 ,  G16B50/40 ,  G06V10/30 ,  G06V20/69 ,  G06V10/50 ,  G06V10/75 ,  G16B50/00 ,  G01N21/75

CPC classification number: G16B40/10 ,  C12Q1/6841 ,  G01N21/6428 ,  G01N21/6456 ,  G01N21/6458 ,  G02B21/0076 ,  G02B21/16 ,  G02B21/365 ,  G02B21/367 ,  G06T5/003 ,  G06T5/006 ,  G06T5/20 ,  G06T5/50 ,  G06T7/0012 ,  G06V10/30 ,  G06V10/507 ,  G06V10/758 ,  G06V20/69 ,  G06V20/698 ,  G16B50/00 ,  G16B50/40 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2021/755 ,  G01N2201/12761 ,  G06T2207/10056 ,  G06T2207/10064 ,  G06T2207/30004 ,  G06T2207/30168

Abstract: In acquisition of spatial transcriptomic information, a plurality of images representing a common field of view of a sample are obtained and registered. Each pixel of the registered images is decoded by identifying a code word from a plurality of code words in a code book that provides a best match to data values in the plurality of registered images for the pixel. For each code word identified as a best match and each pixel, whether a bit ratio for an image word for the pixel meets a threshold for the code word is determined. The image word is formed from the data values in the plurality of registered images for the pixel. For at least one pixel that is determined to meet the threshold, a gene associated with the code word is determined. Pixels for which the bit ratio does not meet the threshold are screened.