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公开(公告)号:US09260517B2
公开(公告)日:2016-02-16
申请号:US13510270
申请日:2010-11-17
CPC分类号: C07K16/28 , A61K47/6843 , C07K16/18 , C07K16/30 , C07K16/3015 , C07K16/303 , C07K16/3038 , C07K16/3069 , C07K2317/21 , C07K2317/73 , C07K2317/734 , C07K2317/76
摘要: The present invention provides for methods of producing human monoclonal antibodies to human nucleolin, cells producing such antibodies, and the antibodies themselves. Also provided are methods of using the antibodies in diagnosing and treating malignant and non-malignant diseases wherein cells that express nucleolin on the cell surface contribute to the pathophysiology of the disease.
摘要翻译: 本发明提供了制备人核仁素的人单克隆抗体,产生这种抗体的细胞和抗体本身的方法。 还提供了使用抗体诊断和治疗恶性和非恶性疾病的方法,其中在细胞表面上表达核仁素的细胞有助于疾病的病理生理学。
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公开(公告)号:US20130115674A1
公开(公告)日:2013-05-09
申请号:US13510270
申请日:2010-11-17
IPC分类号: C07K16/28
CPC分类号: C07K16/28 , A61K47/6843 , C07K16/18 , C07K16/30 , C07K16/3015 , C07K16/303 , C07K16/3038 , C07K16/3069 , C07K2317/21 , C07K2317/73 , C07K2317/734 , C07K2317/76
摘要: The present invention provides for methods of producing human monoclonal antibodies to human nucleolin, cells producing such antibodies, and the antibodies themselves. Also provided are methods of using the antibodies in diagnosing and treating malignant and non-malignant diseases wherein cells that express nucleolin on the cell surface contribute to the pathophysi-ology of the disease.
摘要翻译: 本发明提供了制备人核仁素的人单克隆抗体,产生这种抗体的细胞和抗体本身的方法。 还提供了使用抗体诊断和治疗恶性和非恶性疾病的方法,其中在细胞表面上表达核仁核的细胞有助于疾病的病理生理学。
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