-
公开(公告)号：US08420663B2
公开(公告)日：2013-04-16
申请号：US13570836
申请日：2012-08-09
申请人： Nataliya Bazhina , George Joseph Donato, III , Steven R. Fabian , John Lokhnauth , Sreenivasulu Megati , Charles K. Melucci , Christian Ofslager , Niketa Patel , Galen Radebaugh , Syed M. Shah , Jan Szeliga , Huyi Zhang , Tianmin Zhu
发明人： Nataliya Bazhina , George Joseph Donato, III , Steven R. Fabian , John Lokhnauth , Sreenivasulu Megati , Charles K. Melucci , Christian Ofslager , Niketa Patel , Galen Radebaugh , Syed M. Shah , Jan Szeliga , Huyi Zhang , Tianmin Zhu
IPC分类号： A61K31/485 , A61K31/4748
CPC分类号： A61K31/485 , A61J1/05 , A61K9/0019 , A61K9/0053 , A61K9/08 , A61K9/20 , A61M5/178 , C07D471/08 , C07D489/08 , Y10T436/145555
摘要： The present invention provides a compound of formula I: wherein X−, R1, and R2 are as defined herein, and compositions thereof.
-
公开(公告)号：US20120316191A1
公开(公告)日：2012-12-13
申请号：US13570836
申请日：2012-08-09
申请人： Nataliya Bazhina , George Joseph Donato, III , Steven R. Fabian , John Lokhnauth , Sreenivasulu Megati , Charles Melucci , Christian Ofslager , Niketa Patel , Galen Radebaugh , Syed M. Shah , Jan Szeliga , Huyi Zhang , Tianmin Zhu
发明人： Nataliya Bazhina , George Joseph Donato, III , Steven R. Fabian , John Lokhnauth , Sreenivasulu Megati , Charles Melucci , Christian Ofslager , Niketa Patel , Galen Radebaugh , Syed M. Shah , Jan Szeliga , Huyi Zhang , Tianmin Zhu
IPC分类号： A61K31/439 , A61P1/10 , A61P1/00
CPC分类号： A61K31/485 , A61J1/05 , A61K9/0019 , A61K9/0053 , A61K9/08 , A61K9/20 , A61M5/178 , C07D471/08 , C07D489/08 , Y10T436/145555
摘要： The present invention provides a compound of formula I: wherein X−, R1, and R2 are as defined herein, and compositions thereof.
摘要翻译： 本发明提供式I化合物：其中X，R 1和R 2如本文所定义，及其组合物。
-
公开(公告)号：US20130011929A1
公开(公告)日：2013-01-10
申请号：US13546500
申请日：2012-07-11
申请人： Nataliya Bazhina , George Joseph Donato, III , Steven R. Fabian , John Lokhnauth , Sreenivasulu Megati , Charles Melucci , Christian Ofslager , Niketa Patel , Galen Radebaugh , Syed M. Shah , Jan Szeliga , Huyi Zhang , Tianmin Zhu
发明人： Nataliya Bazhina , George Joseph Donato, III , Steven R. Fabian , John Lokhnauth , Sreenivasulu Megati , Charles Melucci , Christian Ofslager , Niketa Patel , Galen Radebaugh , Syed M. Shah , Jan Szeliga , Huyi Zhang , Tianmin Zhu
IPC分类号： C07D221/28 , G01N30/02 , G01N33/00
CPC分类号： A61K31/485 , A61J1/05 , A61K9/0019 , A61K9/0053 , A61K9/08 , A61K9/20 , A61M5/178 , C07D471/08 , C07D489/08 , Y10T436/145555
摘要： The present invention provides a compound of formula I: wherein X−, R1, and R2 are as defined herein, and compositions thereof.
-
公开(公告)号：US20100120813A1
公开(公告)日：2010-05-13
申请号：US12570891
申请日：2009-09-30
申请人： Nataliya Bazhina , George Joseph Donato, III , Steven R. Fabian , John Lokhnauth , Sreenivasulu Megati , Charles Melucci , Christian Ofslager , Niketa Patel , Galen Radebaugh , Syed M. Shah , Jan Szeliga , Huyi Zhang , Tianmin Zhu
发明人： Nataliya Bazhina , George Joseph Donato, III , Steven R. Fabian , John Lokhnauth , Sreenivasulu Megati , Charles Melucci , Christian Ofslager , Niketa Patel , Galen Radebaugh , Syed M. Shah , Jan Szeliga , Huyi Zhang , Tianmin Zhu
IPC分类号： A61K31/485 , C07D211/06 , C07D489/02 , A61P1/10 , G01N33/00
CPC分类号： A61K31/485 , A61J1/05 , A61K9/0019 , A61K9/0053 , A61K9/08 , A61K9/20 , A61M5/178 , C07D471/08 , C07D489/08 , Y10T436/145555
摘要： The present invention provides a compound of formula I: wherein X−, R1, and R2 are as defined herein, and compositions thereof.
摘要翻译： 本发明提供式I化合物：其中X，R 1和R 2如本文所定义，及其组合物。
-
公开(公告)号：US08455644B2
公开(公告)日：2013-06-04
申请号：US13546500
申请日：2012-07-11
申请人： Nataliya Bazhina , George Joseph Donato, III , Steven R. Fabian , John Lokhnauth , Sreenivasulu Megati , Charles Melucci , Christian Ofslager , Niketa Patel , Galen Radebaugh , Syed M. Shah , Jan Szeliga , Huyi Zhang , Tianmin Zhu
发明人： Nataliya Bazhina , George Joseph Donato, III , Steven R. Fabian , John Lokhnauth , Sreenivasulu Megati , Charles Melucci , Christian Ofslager , Niketa Patel , Galen Radebaugh , Syed M. Shah , Jan Szeliga , Huyi Zhang , Tianmin Zhu
IPC分类号： C07D221/22 , C07D489/08
CPC分类号： A61K31/485 , A61J1/05 , A61K9/0019 , A61K9/0053 , A61K9/08 , A61K9/20 , A61M5/178 , C07D471/08 , C07D489/08 , Y10T436/145555
摘要： The present invention provides a compound of formula I: wherein X−, R1, and R2 are as defined herein, and compositions thereof.
摘要翻译： 本发明提供式I化合物：其中X，R 1和R 2如本文所定义，及其组合物。
-
公开(公告)号：US08247425B2
公开(公告)日：2012-08-21
申请号：US12570891
申请日：2009-09-30
申请人： Nataliya Bazhina , George Joseph Donato, III , Steven R. Fabian , John Lokhnauth , Sreenivasulu Megati , Charles Melucci , Christian Ofslager , Niketa Patel , Galen Radebaugh , Syed M. Shah , Jan Szeliga , Huyi Zhang , Tianmin Zhu
发明人： Nataliya Bazhina , George Joseph Donato, III , Steven R. Fabian , John Lokhnauth , Sreenivasulu Megati , Charles Melucci , Christian Ofslager , Niketa Patel , Galen Radebaugh , Syed M. Shah , Jan Szeliga , Huyi Zhang , Tianmin Zhu
IPC分类号： A61K31/485 , A61K31/4748
CPC分类号： A61K31/485 , A61J1/05 , A61K9/0019 , A61K9/0053 , A61K9/08 , A61K9/20 , A61M5/178 , C07D471/08 , C07D489/08 , Y10T436/145555
摘要： The present invention provides a compound of formula I: wherein X−, R1, and R2 are as defined herein, and compositions thereof.
摘要翻译： 本发明提供式I化合物：其中X，R 1和R 2如本文所定义，及其组合物。
-
公开(公告)号：US10357449B2
公开(公告)日：2019-07-23
申请号：US15158967
申请日：2016-05-19
IPC分类号： A61K9/00 , A61K47/18 , A61K47/02 , A61K31/485
摘要： The present invention provides formulations that achieve effective delivery of methylnaltrexone compositions. The provided formulations are useful for preventing, treating delaying, diminishing or reducing the severity of side effects resulting from use of analgesic opioids.
-
公开(公告)号：US20100249169A1
公开(公告)日：2010-09-30
申请号：US12726113
申请日：2010-03-17
IPC分类号： A61K31/439
CPC分类号： A61K9/0019 , A61K31/485 , A61K47/02 , A61K47/183
摘要： The present invention provides formulations that achieve effective delivery of methylnaltrexone compositions. The provided formulations are useful for preventing, treating delaying, diminishing or reducing the severity of side effects resulting from use of analgesic opioids.
摘要翻译： 本发明提供实现有效递送甲基纳曲酮组合物的制剂。 所提供的制剂可用于预防，治疗延迟，减少或降低由使用镇痛阿片样物质引起的副作用的严重性。
-
公开(公告)号：US20160338946A1
公开(公告)日：2016-11-24
申请号：US15158967
申请日：2016-05-19
IPC分类号： A61K9/00 , A61K47/18 , A61K47/02 , A61K31/485
CPC分类号： A61K9/0019 , A61K31/485 , A61K47/02 , A61K47/183
摘要： The present invention provides formulations that achieve effective delivery of methylnaltrexone compositions. The provided formulations are useful for preventing, treating delaying, diminishing or reducing the severity of side effects resulting from use of analgesic opioids.
-
公开(公告)号：US20120059025A1
公开(公告)日：2012-03-08
申请号：US13230167
申请日：2011-09-12
申请人： Syed M. Shah , Christian Ofslager
发明人： Syed M. Shah , Christian Ofslager
IPC分类号： A61K31/485 , A61P43/00
CPC分类号： A61K31/485 , A61K9/0019 , A61K9/19 , A61K47/26
摘要： The present invention provides lyophilized formulations comprising methylnaltrexone, and processes for preparation of provided formulations. Additionally provided are compositions and products containing the methylnaltrexone formulation, as well as methods for producing formulations, compositions and products. Provided formulations as well as compositions and products containing methylnaltrexone formulations are useful for preventing, treating delaying, diminishing or reducing the severity and/or incidence of side effects resulting from administration of analgesic opioids.
摘要翻译： 本发明提供了包含甲基纳曲酮的冻干制剂，以及制备所提供的制剂的方法。 另外提供了含有甲基纳曲酮制剂的组合物和产品，以及用于制备制剂，组合物和产品的方法。 提供的制剂以及含有甲基纳曲酮制剂的组合物和产品可用于预防，治疗延迟，减少或降低由施用镇痛阿片样物质引起的副作用的严重性和/或发生率。
-
-
-
-
-
-
-
-
-
搜索结果
14 条记录 (耗时 0.05 秒)
