公开(公告)号：US11739154B2

公开(公告)日：2023-08-29

申请号：US16646823

申请日：2018-09-10

申请人： National Research Council of Canada

发明人： Kevin Henry ,  Maria Luz Jaramillo ,  Colin Roger Mackenzie ,  Anne Marcil

IPC分类号： C07K16/28 ,  A61K47/68 ,  A61P35/00 ,  A61K49/00 ,  C12N5/16 ,  A61K39/00

CPC分类号： C07K16/2863 ,  A61K47/6803 ,  A61K49/00 ,  A61P35/00 ,  C12N5/16 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2319/00

摘要： AXL-specific antibodies and uses therefor are described, including monoclonal and single domain antibodies. Such antibodies bind to cell surface expressed human AXL at an epitope in an immunoglobulin-like (IgL) domain of the AXL ectodomain. The antibody may be used in an antibody-drug conjugate (ADC), for example in the treatment, detection or staging of cancer. The antibody may be biparatopic.

公开(公告)号：US11384141B2

公开(公告)日：2022-07-12

申请号：US17050072

申请日：2019-04-24

申请人： National Research Council of Canada

发明人： Gregory Hussack ,  Jamshid Tanha ,  Kevin Henry ,  Traian Sulea

IPC分类号： C07K16/18

摘要： The present document describes an antibody or an antigen-binding fragment that bind to serum albumin comprising three complementarity determining regions (CDR1, CDR2 and CDR3), for half-life extension of biologics. The present invention also relates to pharmaceutical compositions, nucleic acid vectors, cells comprising the nucleic acid vectors, and methods of removing molecules from serum.