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公开(公告)号：US20230293766A1
公开(公告)日：2023-09-21
申请号：US18017209
申请日：2020-10-22
发明人： Kouji AMANO , Toshiko YOSHIDA , Motonori OKABE , Chika SOKO , Masahiko ARAKAWA
CPC分类号： A61L27/3604 , A61L27/3687 , A61L27/60
摘要： The present invention addresses the problem of providing a wound contact member (or “contact layer”) that directly promotes wound healing when continuously performing negative pressure wound therapy (NPWT). As a solution, there is provided dry amniotic membrane manufactured by a specified drying process, that is, raw amniotic membrane placed inside a processing tank (10) is continuously heated using an infrared heater (14) provided inside the processing tank (10) while performing a depressurization operation that places the processing tank in a depressurized state and irradiation of the raw amniotic membrane with microwaves from a microwave generating device (30) provided inside the processing tank (10) to apply energy to water molecules present inside the amniotic membrane and cause drying during a pressure recovery operation that slightly raises the pressure inside the depressurized processing tank (10) toward atmospheric pressure. Amniotic membrane, which has been dried by repeating the above process and thereby retains its cell and tissue structure, is used as a contact layer when performing negative pressure wound therapy (NPWT) on an open abdominal wound and/or wound dehiscence, which increases the healing effect of NPWT.
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公开(公告)号：US20230310706A1
公开(公告)日：2023-10-05
申请号：US18021864
申请日：2020-11-30
发明人： Jiro OBA , Toshiko YOSHIDA , Motonori OKABE , Chika SOKO , Masahiko ARAKAWA
CPC分类号： A61L27/3604 , A61L27/3687 , A61L27/60
摘要： A raw amniotic membrane placed in a processing tank (10) is continuously heated by a far-IR heater (14) provided in the processing tank (10). During a decompression operation in which the interior of the processing tank (10) is placed in a decompressed state, and a recompression operation in which the pressure in the decompressed interior of the processing tank (10) is raised slightly toward atmospheric pressure, the raw amniotic membrane is dried while the water molecules present therein are subjected to energy via microwave irradiation from a microwave irradiation device (30) provided in the processing tank (10). By repeating this multiple times, the amniotic membrane is dried while cells and tissue structures are maintained. The amniotic membrane can be used on a wound site as a coating material or scaffold material after removing a necrosis layer and the like from a severe burn wound patient to retain cytokines and physiologically active substances secreted from infiltrating cells and promote favorable granulation including neoangiogenesis and growth of fibroblasts. This enhances the probability of survival of the patient and therapeutic effect (without the risk of keloid formation).
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公开(公告)号：US20230293767A1
公开(公告)日：2023-09-21
申请号：US18021113
申请日：2020-10-30
发明人： Michiro FUJISAKA , Hideo SHOJAKU , Shinsuke ITO , Toshiko YOSHIDA , Motonori OKABE , Chika SOKO , Masahiko ARAKAWA
CPC分类号： A61L27/3604 , A61L27/3691 , A61L27/54 , A61L27/60 , A61L2430/14
摘要： The present invention addresses the problem of providing a material as a scaffold used to prevent poor skin grafting when there is a defect in the perichondrium or periosteum or a defect in subcutaneous tissue. As a solution, there is provided a dry amniotic membrane manufactured according to a specific drying process. In more detail, a raw amniotic membrane placed in a processing tank (10) is continuously heated by a far-infrared heater (14) provided inside the processing tank (10), while performing a decompression operation where the interior of the processing tank (10) is placed in a decompressed state and irradiation of the raw amniotic membrane with microwaves from a microwave generating device (30) provided inside the processing tank (10) to apply energy to water molecules present inside the amniotic membrane and cause drying during a pressure recovery operation that slightly raises the pressure inside the depressurized processing tank (10) toward atmospheric pressure. By providing amniotic membrane, which has been dried by repeating the above process a plurality of times to retain its cellular and tissue structure, as a scaffold used to prevent poor skin grafting when there is a defect in the perichondrium or periosteum or a defect in the subcutaneous tissue, it is possible to enhance the healing effect of a skin graft.
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