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1.发明申请公开(公告)号：US20220233624A9
公开(公告)日：2022-07-28
申请号：US17192712
申请日：2021-03-04
申请人： Natreon, Inc.
发明人： Sanyasi R. Kalidindi , Jugnu Jain , Bhawana Gupta
摘要： The present invention is directed to methods of treating cancer and inhibiting proliferation of cancer cells with compositions comprising extracts prepared from Terminalia chebula fruits (for instance AyuFlex®), Terminalia bellerica fruits (for instance Ayuric®), Phyllanthus emblica fruits (for instance Capros®), Withania somnifera roots and leaves (for instance Sensoril®), Shilajit (for instance PrimaVie®), Azadirachta indica leaves and twigs (for instance PhytoBGS®), and/or combinations thereof, including a trivalent chromium complex with extracts of Shilajit and P. emblica (e.g. Crominex-3+®). Combinations of the extracts with anti-cancer drugs, and related methods, are also described.
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2.发明申请公开(公告)号：US20210315959A1
公开(公告)日：2021-10-14
申请号：US17192712
申请日：2021-03-04
申请人： Natreon, Inc.
发明人： Sanyasi R. Kalidindi , Jugnu Jain , Bhawana Gupta
摘要： The present invention is directed to methods of treating cancer and inhibiting proliferation of cancer cells with compositions comprising extracts prepared from Terminalia chebula fruits (for instance AyuFlex®), Terminalia bellerica fruits (for instance Ayuric®), Phyllanthus emblica fruits (for instance Capros®), Withania somnifera roots and leaves (for instance Sensoril®), Shilajit (for instance PrimaVie®), Azadirachta indica leaves and twigs (for instance PhytoBGS®), and/or combinations thereof, including a trivalent chromium complex with extracts of Shilajit and P. emblica (e.g. Crominex-3+®). Combinations of the extracts with anti-cancer drugs, and related methods, are also described.
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3.发明申请CHROMIUM-CONTAINING COMPOSITIONS IN COMBINATION WITH PHYLLANTHUS EMBLICA AND SHILAJIT HAVING SYNERGISTIC EFFECTS FOR IMPROVING ENDOTHELIAL FUNCTION AND CARDIOVASCULAR HEALTH 审中-公开与含有PHYLLANTHUS EMBLICA和SHILAJIT组合的含铬组合物具有改善内皮功能和心血管健康的协同效应公开(公告)号：US20160074452A1
公开(公告)日：2016-03-17
申请号：US14947987
申请日：2015-11-20
申请人： Natreon, Inc.
发明人： Sanyasi R. Kalidindi
IPC分类号： A61K36/185 , A61K35/04 , A61K33/24
CPC分类号： A61K36/185 , A61K31/194 , A61K31/366 , A61K33/24 , A61K35/04 , A61K36/47 , A61K2300/00
摘要： Chromium-three cation containing compositions in synergistic combination with Phyllanthus emblica extract and Shilajit are useful for improvement of endothelial function and cardiovascular health, including treatment of type 2 diabetes and metabolic syndrome.
摘要翻译： 含有三氧化锰的组合物与竹叶提取物和Shilajit的协同组合可用于改善内皮功能和心血管健康，包括治疗2型糖尿病和代谢综合征。
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公开(公告)号：US20220202887A1
公开(公告)日：2022-06-30
申请号：US17558900
申请日：2021-12-22
申请人： Natreon, Inc.
IPC分类号： A61K36/185 , A61P25/28 , A61P9/10
摘要： This invention is directed to methods of attenuating brain injury and providing neuroprotection to the brain from injury such as from stroke, by administering compositions containing extracts of Phyllanthus emblica; and related methods.
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公开(公告)号：US20190388322A1
公开(公告)日：2019-12-26
申请号：US16018876
申请日：2018-06-26
申请人： Natreon, Inc.
摘要： Methods of using Shilajit or its individual components, or a combination of two or more of these components, to improve skin microperfusion, to upregulate ECM related genes in the skin, to increase endothelial cell migration and growth of blood vessels, and thus to improve skin health are presented herein.
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公开(公告)号：US10449206B2
公开(公告)日：2019-10-22
申请号：US14805024
申请日：2015-07-21
申请人： Natreon, Inc.
摘要： A group of indolealkylamino-withasteroid conjugates, isolated and purified from Withania somnifera, are described. A synthetic method of making an indolealkylamino-withasteroid compound is provided. In vitro acetyl cholinesterase inhibitory activity and methods for treatment of dementia and dementia-related disorders, such as Alzheimer's disease, and anxiety and depressive disorders in mammals are demonstrated with these novel compositions.
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公开(公告)号：US20150320771A1
公开(公告)日：2015-11-12
申请号：US14805024
申请日：2015-07-21
申请人： Natreon, Inc.
IPC分类号： A61K31/585
CPC分类号： A61K31/585 , A61K36/38 , A61K47/541 , A61K47/545 , C07J71/001
摘要： A group of indolealkylamino-withasteroid conjugates, isolated and purified from Withania somnifera, are described. A synthetic method of making an indolealkylamino-withasteroid compound is provided. In vitro acetyl cholinesterase inhibitory activity and methods for treatment of dementia and dementia-related disorders, such as Alzheimer's disease, and anxiety and depressive disorders in mammals are demonstrated with these novel compositions.
摘要翻译： 描述了分离和纯化的从吲哚胺（Anania somnifera）中的一组吲哚烷基氨基 - 无主义结合物。 提供了制备吲哚烷基氨基 - 蒽醌类化合物的合成方法。 用这些新型组合物证明了体外乙酰胆碱酯酶抑制活性和用于治疗痴呆和痴呆相关疾病如阿尔茨海默病和哺乳动物中的焦虑和抑郁障碍的方法。
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公开(公告)号：US20220288148A1
公开(公告)日：2022-09-15
申请号：US17690837
申请日：2022-03-09
申请人： Natreon, Inc.
发明人： Sanyasi R. Kalidindi
摘要： Methods of relieving back pain with Terminalia chebula compositions are described.
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公开(公告)号：US11077045B2
公开(公告)日：2021-08-03
申请号：US16018876
申请日：2018-06-26
申请人： Natreon, Inc.
摘要： Methods of using Shilajit or its individual components, or a combination of two or more of these components, to improve skin microperfusion, to upregulate ECM related genes in the skin, to increase endothelial cell migration and growth of blood vessels, and thus to improve skin health are presented herein.
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10.发明申请CHROMIUM-CONTAINING COMPOSITIONS FOR IMPROVING ENDOTHELIAL FUNCTION AND CARDIOVASCULAR HEALTH 审中-公开用于改善内皮功能和心血管健康的含铬组合物公开(公告)号：US20160015740A1
公开(公告)日：2016-01-21
申请号：US14718613
申请日：2015-05-21
申请人： Natreon, Inc.
发明人： Sanyasi R. Kalidindi
IPC分类号： A61K33/24 , A61K35/04 , A61K36/185
CPC分类号： A61K33/24 , A61K31/365 , A61K35/04 , A61K36/185 , A61K36/47 , A61K2300/00
摘要： Chromium-three cation containing compositions in combination with Phyllanthus emblica extract and Shilajit are useful for improvement of endothelial function and cardiovascular health, including treatment of type 2 diabetes and metabolic syndrome.
摘要翻译： 含有三价阳离子的组合物与竹叶提取物和Shilajit组合可用于改善内皮功能和心血管健康，包括治疗2型糖尿病和代谢综合征。
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