公开(公告)号：US08883517B2

公开(公告)日：2014-11-11

申请号：US13395723

申请日：2010-09-14

Applicant: Neil James Cook

Inventor： Neil James Cook

IPC: G01N33/559 ,  G01N33/564 ,  G01N33/561

CPC classification number: G01N33/564 ,  G01N33/561

Abstract: The present invention relates to a method of detecting a target antibody, particularly a target autoantibody, in a sample, using a small molecule fluorophore-labelled target antigen, or a functional fragment, functional variant or functional derivative thereof that specifically binds to the target antibody. Detection is typically carried out using immunodiffusion or immunoelectrophoresis. The invention also relates to methods of diagnosing disease, particularly autoimmune disease, using small molecule fluorophore labelled target antigens and autoantigens. Small molecule fluorophore labelled target antigens, including autoantigens, are also disclosed, as are uses such.

Abstract translation: 本发明涉及使用特异性结合靶抗体的小分子荧光团标记的靶抗原或其功能性片段，功能性变体或功能性衍生物来检测样品中的靶抗体，特别是靶自身抗体的方法 。 检测通常使用免疫扩散或免疫电泳进行。 本发明还涉及使用小分子荧光团标记的靶抗原和自身抗原来诊断疾病，特别是自身免疫性疾病的方法。 还公开了小分子荧光团标记的靶抗原，包括自身抗原，以及其用途。

公开(公告)号：US20120276655A1

公开(公告)日：2012-11-01

申请号：US13395723

申请日：2010-09-14

Applicant: Neil James Cook

Inventor： Neil James Cook

IPC: G01N21/64 ,  C07K14/47

CPC classification number: G01N33/564 ,  G01N33/561

Abstract: The present invention relates to a method of detecting a target antibody, particularly a target autoantibody, in a sample, using a small molecule fluorophore-labelled target antigen, or a functional fragment, functional variant or functional derivative thereof that specifically binds to the target antibody. Detection is typically carried out using immunodiffusion or immunoelectrophoresis. The invention also relates to methods of diagnosing disease, particularly autoimmune disease, using small molecule fluorophore labelled target antigens and autoantigens. Small molecule fluorophore labelled target antigens, including autoantigens, are also disclosed, as are uses such.

Abstract translation: 本发明涉及使用特异性结合靶抗体的小分子荧光团标记的靶抗原或其功能性片段，功能性变体或功能性衍生物来检测样品中的靶抗体，特别是靶自身抗体的方法 。 检测通常使用免疫扩散或免疫电泳进行。 本发明还涉及使用小分子荧光团标记的靶抗原和自身抗原来诊断疾病，特别是自身免疫性疾病的方法。 还公开了小分子荧光团标记的靶抗原，包括自身抗原，以及其用途。