公开(公告)号：US11746149B2

公开(公告)日：2023-09-05

申请号：US16626630

申请日：2018-06-27

Applicant: Neuracle Science Co., Ltd.

Inventor： Bongcheol Kim ,  Dong Sik Kim ,  Soon-gu Kwon

IPC: A61K39/395 ,  A61K39/00 ,  C07K16/24

CPC classification number: C07K16/24 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76

Abstract: The present disclosure relates to the pharmaceutical use of antagonists (e.g., an antibody or antigen-binding portion thereof) that specifically bind to FAM19A5 to treat a glaucoma in a subject in need thereof.

公开(公告)号：US11560425B2

公开(公告)日：2023-01-24

申请号：US16626625

申请日：2018-06-27

Applicant: Neuracle Science Co., Ltd.

Inventor： Bongcheol Kim ,  Eun Bee Cho ,  Dong Sik Kim ,  Jae-Keun Lee ,  Soon-gu Kwon ,  Jae Young Seong ,  Juwon Shim ,  Tae Woo Kim ,  Shin-hyuk Kang

IPC: C07K16/24 ,  C07K16/30 ,  A61P35/00 ,  A61K45/06 ,  A61K39/00 ,  C07K16/28 ,  A61K39/395

Abstract: The present disclosure relates to the pharmaceutical use of antagonists (e.g., an antibody or antigen-binding portion thereof) that specifically bind to FAM19A5 to promote a blood vessel normalization and treat a disease (e.g., cancer) in a subject in need thereof, e.g., by promoting a blood vessel normalization.

公开(公告)号：US12215338B2

公开(公告)日：2025-02-04

申请号：US17053733

申请日：2019-05-08

Applicant: Neuracle Science Co., Ltd. ,  Neuracle Genetics

Inventor： Jong-Mook Kim ,  Dong Sik Kim ,  Juwon Shim ,  Soon-gu Kwon

IPC: A61K48/00 ,  C07K16/24 ,  C12N15/86 ,  A61K39/00

Abstract: The present disclosure provides adeno-associated vims (AAV) vectors and uses thereof. In certain embodiments, the AAV vectors comprise a nucleic acid that encodes an antagonist against a family with sequence similarity 19, member A5 (FAM19A5) protein, e.g., anti-FAM19A5 antibody, e.g., anti-FAM19A5 scFv.