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1.发明授权公开(公告)号：US10344080B2
公开(公告)日：2019-07-09
申请号：US15106176
申请日：2014-12-22
发明人： Jan Grimm , Aubin Michalon
摘要： Provided are novel human-derived antibodies specific for transthyretin (TTR), preferably capable of binding misfolded, misassembled, and/or aggregated TTR species, as well as methods related thereto. In addition, methods of diagnosing and/or monitoring diseases and treatments thereof which are associated with TTR amyloidosis are provided. Assays and kits related to antibodies specific for TTR or TTR deposits and aggregates are also disclosed. The novel anti-TTR antibodies can be used in pharmaceutical and diagnostic compositions for TTR targeted immunotherapy and diagnostics.
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2.发明授权公开(公告)号：US11180545B2
公开(公告)日：2021-11-23
申请号：US16413335
申请日：2019-05-15
发明人： Jan Grimm , Aubin Michalon
IPC分类号： A61K39/00 , A61K39/395 , A61K38/17 , C07K16/18 , G01N33/68
摘要： Provided are novel human-derived antibodies specific for transthyretin (TTR), preferably capable of binding misfolded, misassembled, and/or aggregated TTR species, as well as methods related thereto. In addition, methods of diagnosing and/or monitoring diseases and treatments thereof which are associated with TTR amyloidosis are provided. Assays and kits related to antibodies specific for TTR or TTR deposits and aggregates are also disclosed. The novel anti-TTR antibodies can be used in pharmaceutical and diagnostic compositions for TTR targeted immunotherapy and diagnostics.
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