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公开(公告)号：US10882902B2
公开(公告)日：2021-01-05
申请号：US16058630
申请日：2018-08-08
发明人： Jan Grimm , Fabrice Heitz , Feng Chen , Ioana Combaluzier
IPC分类号： C07K16/18 , A61K47/68 , G01N33/577 , G01N33/68 , C07K14/47 , C07K7/06 , G01N33/543 , A61K39/00
摘要： Provided are novel human islet amyloid polypeptide, also known as amylin and IAPP and proIAPP respectively, specific antibodies as well as fragments, derivatives and variants thereof as well as methods related thereto. Assays, kits, and solid supports related to antibodies specific for IAPP and/or proIAPP are also disclosed. The antibody, immunoglobulin chain(s), as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for IAPP and/or proIAPP targeted immunotherapy and diagnostics, respectively.
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公开(公告)号：US20200010567A1
公开(公告)日：2020-01-09
申请号：US16434654
申请日：2019-06-07
发明人： Fabio MONTRASIO , Jan GRIMM
摘要： Provided are novel human-derived dipeptide repeat (DPR) specific antibodies as well as synthetic variants and biotechnological derivatives thereof, preferably capable of binding C9ORF72 DPRs, as well as methods related thereto. Assays, kits, and solid supports related to antibodies specific for DPRs and DPR proteins such C9ORF72 DPRs are also disclosed. The antibody of the present invention can be used in pharmaceutical and diagnostic compositions for DPR protein-targeted immunotherapy and diagnostics.
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公开(公告)号：US10392447B2
公开(公告)日：2019-08-27
申请号：US15508343
申请日：2015-09-30
发明人： Fabio Montrasio , Jan Grimm
摘要： Provided are novel human-derived dipeptide repeat (DPR) specific antibodies as well as synthetic variants and biotechnological derivatives thereof, preferably capable of binding C9ORF72 DPRs, as well as methods related thereto. Assays, kits, and solid supports related to antibodies specific for DPRs and DPR proteins such C9ORF72 DPRs are also disclosed. The antibody of the present invention can be used in pharmaceutical and diagnostic compositions for DPR protein-targeted immunotherapy and diagnostics.
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公开(公告)号：US10344097B2
公开(公告)日：2019-07-09
申请号：US15014215
申请日：2016-02-03
发明人： Fabio Montrasio , Maria Grazia Barenco Montrasio , Jan Grimm , Roger Nitsch , Christoph Hock , Tobias Welt , Jordan Mcafoose , Marcel Maier
IPC分类号： A61K39/395 , C07K16/40 , A61K39/00 , C07K14/435 , C12N9/02 , A61K45/06 , A61K49/08 , A61K51/10 , G01N33/573 , G01N33/577 , A61K47/68 , G01N33/68
摘要： Provided are novel human copper-zinc superoxide dismutase, also known as superoxide dismutase 1 or SOD1, specific antibodies as well as fragments, derivatives and variants thereof as well as methods related thereto. Assays, kits, and solid supports related to antibodies specific for SOD1 are also disclosed. The antibody, immunoglobulin chain(s), as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for SOD1 targeted immunotherapy and diagnosis, respectively.
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公开(公告)号：US10072074B2
公开(公告)日：2018-09-11
申请号：US15258883
申请日：2016-09-07
发明人： Jan Grimm , Fabrice Heitz , Feng Chen , Ioana Combaluzier
IPC分类号： C07K16/18 , A61K39/395 , G01N33/577 , G01N33/68 , C07K14/47 , C07K7/06 , G01N33/543 , A61K39/00
摘要： Provided are novel human islet amyloid polypeptide, also known as amylin and IAPP and proIAPP respectively, specific antibodies as well as fragments, derivatives and variants thereof as well as methods related thereto. Assays, kits, and solid supports related to antibodies specific for IAPP and/or proIAPP are also disclosed. The antibody, immunoglobulin chain(s), as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for IAPP and/or proIAPP targeted immunotherapy and diagnostics, respectively.
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公开(公告)号：US20230287106A1
公开(公告)日：2023-09-14
申请号：US18053842
申请日：2022-11-09
发明人： Jan GRIMM , Fabrice HEITZ , Fabian WIRTH , Tobias WELT
IPC分类号： C07K16/26 , A01K67/027 , C07K16/18 , A61K47/68 , A61P3/10 , A61K39/395 , A61K45/06 , A61K49/00
CPC分类号： C07K16/26 , A01K67/0275 , A61K39/3955 , A61K45/06 , A61K47/6847 , A61K49/0008 , A61P3/10 , C07K16/18 , A61K2039/505
摘要： Described are molecules specifically binding to human islet amyloid polypeptide (hIAPP) also known as amylin, particularly human-derived antibodies as well as fragments, derivatives and variants thereof for antagonizing islet amyloid polypeptide (IAPP) induced β-cell damage and impaired glucose tolerance which are symptoms typically associated with diabetes mellitus type 2 (T2D).
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公开(公告)号：US10961322B2
公开(公告)日：2021-03-30
申请号：US16434654
申请日：2019-06-07
发明人： Fabio Montrasio , Jan Grimm
摘要： Provided are novel human-derived dipeptide repeat (DPR) specific antibodies as well as synthetic variants and biotechnological derivatives thereof, preferably capable of binding C9ORF72 DPRs, as well as methods related thereto. Assays, kits, and solid supports related to antibodies specific for DPRs and DPR proteins such C9ORF72 DPRs are also disclosed. The antibody of the present invention can be used in pharmaceutical and diagnostic compositions for DPR protein-targeted immunotherapy and diagnostics.
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公开(公告)号：US10450365B2
公开(公告)日：2019-10-22
申请号：US15678965
申请日：2017-08-16
发明人： Jan Grimm , Roland Martin , Benoit Combaluzier , Ivan Jelcic
IPC分类号： A61K39/42 , A61K45/06 , C07K14/005 , C12N7/00 , C07K16/08 , G01N33/569 , G01N33/68
摘要： Provided are novel human-derived antibodies specifically recognizing polyomavirus polypeptides, preferably capable of binding to polyomaviruses of the type of JC virus (JCV) and/or BK virus (BKV) as well as methods related thereto. Furthermore, assays and kits related to antibodies specific for polyomaviruses, polyomavirus VP1 and or polyomavirus VP1 Virus-Like Particles (VLPs), preferably of the type of JCV and/or BKV, are disclosed. The human-derived antibodies as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for polyomavirus targeted immunotherapy and diagnostics.
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9.发明授权公开(公告)号：US10344080B2
公开(公告)日：2019-07-09
申请号：US15106176
申请日：2014-12-22
发明人： Jan Grimm , Aubin Michalon
摘要： Provided are novel human-derived antibodies specific for transthyretin (TTR), preferably capable of binding misfolded, misassembled, and/or aggregated TTR species, as well as methods related thereto. In addition, methods of diagnosing and/or monitoring diseases and treatments thereof which are associated with TTR amyloidosis are provided. Assays and kits related to antibodies specific for TTR or TTR deposits and aggregates are also disclosed. The novel anti-TTR antibodies can be used in pharmaceutical and diagnostic compositions for TTR targeted immunotherapy and diagnostics.
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公开(公告)号：US20170247471A1
公开(公告)日：2017-08-31
申请号：US15508343
申请日：2015-09-30
发明人： Fabio MONTRASIO , Jan GRIMM
CPC分类号： C07K16/44 , A61P25/28 , C07K2317/21 , C07K2317/33 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N2800/2814
摘要： Provided are novel human-derived dipeptide repeat (DPR) specific antibodies as well as synthetic variants and biotechnological derivatives thereof, preferably capable of binding C9ORF72 DPRs, as well as methods related thereto. Assays, kits, and solid supports related to antibodies specific for DPRs and DPR proteins such C9ORF72 DPRs are also disclosed. The antibody of the present invention can be used in pharmaceutical and diagnostic compositions for DPR protein-targeted immunotherapy and diagnostics.
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