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公开(公告)号：US20140106059A1
公开(公告)日：2014-04-17
申请号：US13651977
申请日：2012-10-15
发明人： Rajesh N. Dave , Daniel To , Maxx Capece
CPC分类号： A61K9/5042 , A61K9/5063 , A61K9/5073 , A61K9/5089 , A61K35/00
摘要： The present invention is a solventless method of producing polymer coated active pharmaceutical ingredient that is taste-masked and may be released in relatively short time. It employs high energy vibrations or acoustic mixing of API particles, water soluble coating material particles and hydrophobic polymer particles, with or without use of other pharmaceutically relevant powders as media. Additionally the method is capable of producing individually coated drug particles without agglomeration or the long drying times associated with solvent based coating methods.
摘要翻译： 本发明是一种制造聚合物涂覆的活性药物成分的无溶剂方法，其具有掩味作用并且可在较短时间内释放。 它使用API颗粒，水溶性涂层材料颗粒和疏水性聚合物颗粒的高能量振动或声音混合，有或没有使用其它药学上相关的粉末作为介质。 此外，该方法能够产生单独涂覆的药物颗粒而不发生附聚或与溶剂型涂布方法相关的长时间干燥时间。
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公开(公告)号：US09107851B2
公开(公告)日：2015-08-18
申请号：US13651977
申请日：2012-10-15
发明人： Rajesh N. Dave , Daniel To , Maxx Capece
CPC分类号： A61K9/5042 , A61K9/5063 , A61K9/5073 , A61K9/5089 , A61K35/00
摘要： The present invention is a solventless method of producing polymer coated active pharmaceutical ingredient that is taste-masked and may be released in relatively short time. It employs high energy vibrations or acoustic mixing of API particles, water soluble coating material particles and hydrophobic polymer particles, with or without use of other pharmaceutically relevant powders as media. Additionally the method is capable of producing individually coated drug particles without agglomeration or the long drying times associated with solvent based coating methods.
摘要翻译： 本发明是一种制造聚合物涂覆的活性药物成分的无溶剂方法，其具有掩味作用并且可在较短时间内释放。 它使用API颗粒，水溶性涂层材料颗粒和疏水性聚合物颗粒的高能量振动或声音混合，有或没有使用其它药学上相关的粉末作为介质。 此外，该方法能够产生单独涂覆的药物颗粒而不发生附聚或与溶剂型涂布方法相关的长时间干燥时间。
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