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公开(公告)号：US09107851B2
公开(公告)日：2015-08-18
申请号：US13651977
申请日：2012-10-15
发明人： Rajesh N. Dave , Daniel To , Maxx Capece
CPC分类号： A61K9/5042 , A61K9/5063 , A61K9/5073 , A61K9/5089 , A61K35/00
摘要： The present invention is a solventless method of producing polymer coated active pharmaceutical ingredient that is taste-masked and may be released in relatively short time. It employs high energy vibrations or acoustic mixing of API particles, water soluble coating material particles and hydrophobic polymer particles, with or without use of other pharmaceutically relevant powders as media. Additionally the method is capable of producing individually coated drug particles without agglomeration or the long drying times associated with solvent based coating methods.
摘要翻译： 本发明是一种制造聚合物涂覆的活性药物成分的无溶剂方法，其具有掩味作用并且可在较短时间内释放。 它使用API颗粒，水溶性涂层材料颗粒和疏水性聚合物颗粒的高能量振动或声音混合，有或没有使用其它药学上相关的粉末作为介质。 此外，该方法能够产生单独涂覆的药物颗粒而不发生附聚或与溶剂型涂布方法相关的长时间干燥时间。
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2.发明授权Taste masked active pharmaceutical powder compositions and processes for making them 有权味道掩蔽的活性药物粉末组合物及其制备方法公开(公告)号：US08993041B2
公开(公告)日：2015-03-31
申请号：US13651829
申请日：2012-10-15
发明人： Daniel To , Rajesh N. Dave
CPC分类号： A61K9/501 , A61K9/5026 , A61K9/5042 , A61K9/5089
摘要： A taste masked particulate pharmaceutical formulation include a core that comprises an active pharmaceutical ingredient; at least a partial nanoparticle material layer on the core that comprises a nanoparticle material with a median particle size not greater than 100 nm; a first polymer layer that is at least partially water soluble and a second polymer layer that is water insoluble. The active pharmaceutical ingredient is completely released in 30 minutes in the USP Dissolution Test. A process of making the particulate pharmaceutical formulation using sequential fluidized bed coating steps under controlled conditions is also described.
摘要翻译： 掩味的颗粒药物制剂包括包含活性药物成分的核心; 所述芯上至少包含中值粒径不大于100nm的纳米颗粒材料的部分纳米颗粒材料层; 至少部分水溶性的第一聚合物层和水不溶性的第二聚合物层。 在USP溶出度测试中，活性药物成分在30分钟内完全释放。 还描述了在受控条件下使用顺序流化床涂布步骤制备颗粒药物制剂的方法。
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3.发明申请TASTE MASKED ACTIVE PHARMACEUTICAL POWDER COMPOSITIONS AND PROCESSES FOR MAKING THEM 有权用于制作活性药用粉末的组合物及其制备方法公开(公告)号：US20140106058A1
公开(公告)日：2014-04-17
申请号：US13651829
申请日：2012-10-15
发明人： Daniel To , Rajesh N. Dave
IPC分类号： B05D5/00
CPC分类号： A61K9/501 , A61K9/5026 , A61K9/5042 , A61K9/5089
摘要： A taste masked particulate pharmaceutical formulation include a core that comprises an active pharmaceutical ingredient; at least a partial nanoparticle material layer on the core that comprises a nanoparticle material with a median particle size not greater than 100 nm; a first polymer layer that is at least partially water soluble and a second polymer layer that is water insoluble. The active pharmaceutical ingredient is completely released in 30 minutes in the USP Dissolution Test. A process of making the particulate pharmaceutical formulation using sequential fluidized bed coating steps under controlled conditions is also described.
摘要翻译： 掩味的颗粒药物制剂包括包含活性药物成分的核心; 所述芯上至少包含中值粒径不大于100nm的纳米颗粒材料的部分纳米颗粒材料层; 至少部分水溶性的第一聚合物层和水不溶性的第二聚合物层。 在USP溶出度测试中，活性药物成分在30分钟内完全释放。 还描述了在受控条件下使用顺序流化床涂布步骤制备颗粒药物制剂的方法。
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公开(公告)号：US09801820B2
公开(公告)日：2017-10-31
申请号：US14441970
申请日：2013-11-08
CPC分类号： A61K9/1676 , A61K9/14 , A61K9/141 , A61K9/145 , A61K9/1611 , A61K9/1623 , A61K9/1652 , A61K9/1682 , A61K9/1694 , A61K9/20 , A61K9/2077 , A61K9/501 , A61K9/5078 , A61K9/5089 , A61K31/216 , B05D1/22
摘要： A composite particle including a core with at least one carrier material; a fluidizing material layer on the surface of the core; and an outer layer comprising nanoparticles of an ingestible material distributed in at least one matrix-forming material. A process of making the composite particles includes the steps of dry coating carrier particles with a fluidizing material; preparing a suspension of nanoparticles of an ingestible material distributed in a matrix-forming material; and fluid bed coating the carrier particles with the suspension. The process and products provide quick dissolving composite particles which can be used for delivery of poorly water soluble ingestible materials in suitable dosage forms. The process of the invention reduces or prevents particle agglomeration during fabrication of the composite particles to enable delivery and quick redispersion of nanoparticles of the ingestible material from a dosage form.
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5.发明申请公开(公告)号：US20150297521A1
公开(公告)日：2015-10-22
申请号：US14441970
申请日：2013-11-08
IPC分类号： A61K9/16 , B05D1/22 , A61K31/216
CPC分类号： A61K9/1676 , A61K9/14 , A61K9/141 , A61K9/145 , A61K9/1611 , A61K9/1623 , A61K9/1652 , A61K9/1682 , A61K9/1694 , A61K9/20 , A61K9/2077 , A61K9/501 , A61K9/5078 , A61K9/5089 , A61K31/216 , B05D1/22
摘要： A composite particle including a core with at least one carrier material; a fluidizing material layer on the surface of the core; and an outer layer comprising nanoparticles of an ingestible material distributed in at least one matrix-forming material. A process of making the composite particles includes the steps of dry coating carrier particles with a fluidizing material; preparing a suspension of nanoparticles of an ingestible material distributed in a matrix-forming material; and fluid bed coating the carrier particles with the suspension. The process and products provide quick dissolving composite particles which can be used for delivery of poorly water soluble ingestible materials in suitable dosage forms. The process of the invention reduces or prevents particle agglomeration during fabrication of the composite particles to enable delivery and quick redispersion of nanoparticles of the ingestible material from a dosage form.
摘要翻译： 包括具有至少一种载体材料的芯的复合颗粒; 在芯的表面上的流化材料层; 以及包含分布在至少一种基质形成材料中的可摄取材料的纳米颗粒的外层。 制造复合颗粒的方法包括用流化材料干燥涂布载体颗粒的步骤; 制备分布在基质形成材料中的可摄取材料的纳米颗粒的悬浮液; 并且将载体颗粒与悬浮液一起涂覆的流化床。 该方法和产品提供快速溶解的复合颗粒，其可用于以合适的剂型递送水溶性差的可摄取材料。 本发明的方法在制备复合颗粒期间降低或防止颗粒聚集，以使得能够从剂型中输送并快速再分散可摄取材料的纳米颗粒。
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公开(公告)号：US20140106059A1
公开(公告)日：2014-04-17
申请号：US13651977
申请日：2012-10-15
发明人： Rajesh N. Dave , Daniel To , Maxx Capece
CPC分类号： A61K9/5042 , A61K9/5063 , A61K9/5073 , A61K9/5089 , A61K35/00
摘要： The present invention is a solventless method of producing polymer coated active pharmaceutical ingredient that is taste-masked and may be released in relatively short time. It employs high energy vibrations or acoustic mixing of API particles, water soluble coating material particles and hydrophobic polymer particles, with or without use of other pharmaceutically relevant powders as media. Additionally the method is capable of producing individually coated drug particles without agglomeration or the long drying times associated with solvent based coating methods.
摘要翻译： 本发明是一种制造聚合物涂覆的活性药物成分的无溶剂方法，其具有掩味作用并且可在较短时间内释放。 它使用API颗粒，水溶性涂层材料颗粒和疏水性聚合物颗粒的高能量振动或声音混合，有或没有使用其它药学上相关的粉末作为介质。 此外，该方法能够产生单独涂覆的药物颗粒而不发生附聚或与溶剂型涂布方法相关的长时间干燥时间。
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