公开(公告)号：US20040127397A1

公开(公告)日：2004-07-01

申请号：US10727565

申请日：2003-12-05

申请人： New River Pharmaceuticals Inc.

发明人： Thomas Piccariello ,  Lawrence P. Olon ,  Randall J. Kirk

IPC分类号： A61K038/00

CPC分类号： A61K31/192 ,  A61K47/55 ,  A61K47/62 ,  A61K47/64

摘要： A composition comprising a polypeptide and an active agent covalently attached to the polypeptide. Also provided is a method for delivery of an active agent to a patient comprising administering to the patient a composition comprising a polypeptide and an active agent covalently attached to the polypeptide. Also provided is a method for protecting an active agent from degradation comprising covalently attaching the active agent to a polypeptide. Also provided is a method for controlling release of an active agent from a composition comprising covalently attaching the active agent to the polypeptide.

公开(公告)号：US20040063628A1

公开(公告)日：2004-04-01

申请号：US10156527

申请日：2002-05-29

申请人： New River Pharmaceuticals Inc.

发明人： Thomas Piccariello ,  Randal J. Kirk ,  Lawrence P. Olon

IPC分类号： A61K038/10 ,  A61K038/08 ,  A61K038/06 ,  A61K038/07 ,  A61K038/05

CPC分类号： A61K9/146 ,  A61K47/34 ,  A61K47/60 ,  A61K47/62 ,  A61K47/64

摘要： The present invention relates to active agent delivery systems and more specifically to compositions that comprise amino acids, as single amino acids or peptides, covalently attached to active agents and methods for administering conjugated active agent compositions.

摘要翻译： 本发明涉及活性剂递送系统，更具体地涉及包含与活性剂共价连接的氨基酸，单个氨基酸或肽的组合物和用于施用共轭活性剂组合物的方法。