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    Antibody-Based Molecules Specific for the Truncated ASP421 Epitope of Tau and Their Uses in the Diagnosis and Treatment of Tauopathy
    1.
    发明申请
    Antibody-Based Molecules Specific for the Truncated ASP421 Epitope of Tau and Their Uses in the Diagnosis and Treatment of Tauopathy 审中-公开

    公开(公告)号：US20190315841A1

    公开(公告)日：2019-10-17

    申请号：US15750975

    申请日：2016-08-11

    Applicant: New York University

    Inventor： Einar Sigurdsson

    IPC: C07K16/18 ,  G01N33/532 ,  A61P25/28

    Abstract: The present invention relates to antibody-based molecules (including single domain antibody fragment, scFv molecules, antibodies, antibody fragments, diabodies, and the epitope-binding domains thereof) that are capable of immunospecifically and selectively binding to the truncated Asp421 epitope of Tau. Such antibody-based molecules are useful to detect pathological Tau protein conformer if present in a biological sample, especially in conjunction with the diagnosis and/or treatment of Alzheimer's disease or other tauopathy, and thus provide a diagnostic for Alzheimer's disease and other Tau pathologies. The antibody-based molecules of the present invention have particular utility as diagnostic markers for, Alzheimer's disease and related tauopathies and as pharmaceutical compositions for the treatment of such conditions.

    Antibody-Based Molecules Specific for the Truncated ASP421 Epitope of Tau and Their Uses in the Diagnosis and Treatment of Tauopathy
    2.
    发明申请
    Antibody-Based Molecules Specific for the Truncated ASP421 Epitope of Tau and Their Uses in the Diagnosis and Treatment of Tauopathy 有权

    公开(公告)号：US20210198349A1

    公开(公告)日：2021-07-01

    申请号：US17176374

    申请日：2021-02-16

    Applicant: New York University

    Inventor： Einar Sigurdsson

    IPC: C07K16/18 ,  A61P25/28 ,  G01N33/532

    Abstract: The present invention relates to antibody-based molecules (including single domain antibody fragment, scFv molecules, antibodies, antibody fragments, diabodies, and the epitope-binding domains thereof) that are capable of immunospecifically and selectively binding to the truncated Asp421 epitope of Tau. Such antibody-based molecules are useful to detect pathological Tau protein conformer if present in a biological sample, especially in conjunction with the diagnosis and/or treatment of Alzheimer's disease or other tauopathy, and thus provide a diagnostic for Alzheimer's disease and other Tau pathologies. The antibody-based molecules of the present invention have particular utility as diagnostic markers for, Alzheimer's disease and related tauopathies and as pharmaceutical compositions for the treatment of such conditions.

    Antibody-based molecules specific for the truncated ASP421 epitope of Tau and their uses in the diagnosis and treatment of tauopathy
    5.
    发明授权
    Antibody-based molecules specific for the truncated ASP421 epitope of Tau and their uses in the diagnosis and treatment of tauopathy 有权

    公开(公告)号：US10988528B2

    公开(公告)日：2021-04-27

    申请号：US15750975

    申请日：2016-08-11

    Applicant: New York University

    Inventor： Einar Sigurdsson

    IPC: C07K16/18 ,  A61P25/28 ,  G01N33/532 ,  A61K38/00

    Abstract: The present invention relates to antibody-based molecules (including single domain antibody fragment, scFv molecules, antibodies, antibody fragments, diabodies, and the epitope-binding domains thereof) that are capable of immunospecifically and selectively binding to the truncated Asp421 epitope of Tau. Such antibody-based molecules are useful to detect pathological Tau protein conformer if present in a biological sample, especially in conjunction with the diagnosis and/or treatment of Alzheimer's disease or other tauopathy, and thus provide a diagnostic for Alzheimer's disease and other Tau pathologies. The antibody-based molecules of the present invention have particular utility as diagnostic markers for, Alzheimer's disease and related tauopathies and as pharmaceutical compositions for the treatment of such conditions.

    Antibody-based molecules selective for the {P}Ser404 epitope of Tau and their uses in the diagnosis and treatment of tauopathy
    6.
    发明授权
    Antibody-based molecules selective for the {P}Ser404 epitope of Tau and their uses in the diagnosis and treatment of tauopathy 有权

    公开(公告)号：US10358503B2

    公开(公告)日：2019-07-23

    申请号：US15750982

    申请日：2016-08-11

    Applicant: New York University

    Inventor： Einar Sigurdsson

    IPC: A61K9/00 ,  A61K39/00 ,  A61K49/00 ,  A61P25/28 ,  C07K16/18 ,  C07K16/44 ,  G01N33/58 ,  G01N33/68

    Abstract: The present invention relates to antibody-based molecules (including single domain antibody fragment, scFv molecules, antibodies, antibody fragments, diabodies, and the epitope-binding domains thereof) that are capable of immunospecifically and selectively binding to the {p}Ser404 Epitope of Tau. Such antibody-based molecules are useful to detect pathological Tau protein conformer if present in a biological sample, especially in conjunction with the diagnosis and/or treatment of Alzheimer's disease or other tauopathy, and thus provide a diagnostic for Alzheimer's disease and other Tau pathologies. The antibody-based molecules of the present invention have particular utility as diagnostic markers for, Alzheimer's disease and related tauopathies and as pharmaceutical compositions for the treatment of such conditions.

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