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![Pyrazolo[5,1b]oxazole Derivatives as CRF-1 Receptor Antagonists](/abs-image/US/2012/11/22/US20120295942A1/abs.jpg.150x150.jpg)
1.发明申请公开(公告)号：US20120295942A1
公开(公告)日：2012-11-22
申请号：US13574200
申请日：2011-01-28
IPC分类号： A61K31/424 , A61P1/00 , A61P1/12 , A61P25/18 , A61P25/24 , A61P17/00 , A61P25/28 , A61P1/16 , A61P29/00 , A61P25/30 , A61P1/08 , C07D498/04 , A61P25/00
CPC分类号： C07D491/048
摘要： There are described 4-difluoromethoxyphenyl pyrazolo[5.1-b]oxazole derivatives useful as corticotropin releasing factor (CRF1) receptor antagonists.
摘要翻译： 描述了可用作促肾上腺皮质激素释放因子（CRF1）受体拮抗剂的4-二氟甲氧基苯基吡唑并[5.1-b]恶唑衍生物。
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![Pyrazolo[5,1b]oxazole derivatives as CRF-1 receptor antagonists](/abs-image/US/2012/04/24/US08163785B2/abs.jpg.150x150.jpg)
2.发明授权公开(公告)号：US08163785B2
公开(公告)日：2012-04-24
申请号：US13017243
申请日：2011-01-31
IPC分类号： A61K31/424 , C07D498/14
CPC分类号： C07D491/048
摘要： There are described 4-difluoromethoxyphenyl pyrazolo[5.1-b]oxazole derivatives of Formula I: which are useful as corticotropin releasing factor (CRF) receptor antagonists and as pharmaceuticals.
摘要翻译： 描述了式I的4-二氟甲氧基苯基吡唑并[5.1-b]恶唑衍生物：其可用作促肾上腺皮质激素释放因子（CRF）受体拮抗剂和药物。
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3.发明申请CYCLOHEXYL AMIDE DERIVATIVES AS CRF RECEPTOR ANTAGONISTS 审中-公开作为CRF受体拮抗剂的CYCLOHEXYL AMIDE DERIVATIVES公开(公告)号：US20110201629A1
公开(公告)日：2011-08-18
申请号：US13017399
申请日：2011-01-31
申请人： Benjamin Atkinson , David Beattie , Andrew James Culshaw , James Dale , Nicholas James Devereux , Jeffrey McKenna
发明人： Benjamin Atkinson , David Beattie , Andrew James Culshaw , James Dale , Nicholas James Devereux , Jeffrey McKenna
IPC分类号： A61K31/522 , C07D209/34 , A61K31/404 , A61P25/18 , A61P25/28 , A61P29/00 , A61P25/30 , A61P1/08 , A61P25/24 , C07D401/12 , A61K31/4439 , C07D471/04 , A61K31/437 , C07D471/10 , C07D217/24 , A61K31/472 , C07D498/04 , C07D473/28
CPC分类号： C07D209/34 , C07D217/24 , C07D401/12 , C07D413/12 , C07D471/04 , C07D471/20 , C07D487/04 , C07D498/04
摘要： There are described cyclohexyl amide derivatives of Formula I, which are useful as corticotropin releasing factor (CRF) receptor antagonists and as pharmaceuticals.
摘要翻译： 描述了式I的环己基酰胺衍生物，其可用作促肾上腺皮质激素释放因子（CRF）受体拮抗剂和药物。
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![PYRAZOLO[5,1B]OXAZOLE DERIVATIVES AS CRF-1 RECEPTOR ANTAGONISTS](/abs-image/US/2011/08/04/US20110190360A1/abs.jpg.150x150.jpg)
4.发明申请公开(公告)号：US20110190360A1
公开(公告)日：2011-08-04
申请号：US13017243
申请日：2011-01-31
IPC分类号： A61K31/424 , C07D498/04 , A61P1/00 , A61P25/24 , A61P25/18 , A61P25/30 , A61P1/08
CPC分类号： C07D491/048
摘要： There are described 4-difluoromethoxyphenyl pyrazolo[5.1-b]oxazole derivatives of Formula I: which are useful as corticotropin releasing factor (CRF) receptor antagonists and as pharmaceuticals.
摘要翻译： 描述了式I的4-二氟甲氧基苯基吡唑并[5.1-b]恶唑衍生物：其可用作促肾上腺皮质激素释放因子（CRF）受体拮抗剂和药物。
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公开(公告)号：US07994203B2
公开(公告)日：2011-08-09
申请号：US12462417
申请日：2009-08-03
申请人： Ian Bruce , Andrew James Culshaw , Nicholas James Devereux , François Gessier , Jeffrey McKenna , James Neef , Helen Elizabeth Oakman
发明人： Ian Bruce , Andrew James Culshaw , Nicholas James Devereux , François Gessier , Jeffrey McKenna , James Neef , Helen Elizabeth Oakman
IPC分类号： A61K31/4162 , C07D489/04
CPC分类号： C07D498/04
摘要： There are described pyrazolo[5.1-b]oxazole derivatives useful as corticotropin releasing factor (CRF1) receptor antagonists.
摘要翻译： 描述了可用作促肾上腺皮质激素释放因子（CRF1）受体拮抗剂的吡唑并[5.1-b]恶唑衍生物。
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公开(公告)号：US20100035874A1
公开(公告)日：2010-02-11
申请号：US12462417
申请日：2009-08-03
申请人： Ian Bruce , Andrew James Culshaw , Nicholas James Devereux , François Gessier , Jeffrey Mc Kenna , James Neef , Helen Elizabeth Oakman
发明人： Ian Bruce , Andrew James Culshaw , Nicholas James Devereux , François Gessier , Jeffrey Mc Kenna , James Neef , Helen Elizabeth Oakman
IPC分类号： A61K31/424 , C07D498/04 , C07D413/14 , A61K31/5377 , A61P43/00
CPC分类号： C07D498/04
摘要： There are described pyrazolo[5.1-b]oxazole derivatives useful as corticotropin releasing factor (CRF1) receptor antagonists.
摘要翻译： 描述了可用作促肾上腺皮质激素释放因子（CRF1）受体拮抗剂的吡唑并[5.1-b]恶唑衍生物。
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公开(公告)号：US08236808B2
公开(公告)日：2012-08-07
申请号：US12995647
申请日：2009-06-08
申请人： Stephen Paul Collingwood , Nicholas James Devereux , Catherine Howsham , Peter Hunt , Thomas Anthony Hunt
发明人： Stephen Paul Collingwood , Nicholas James Devereux , Catherine Howsham , Peter Hunt , Thomas Anthony Hunt
IPC分类号： A61K31/4965 , C07D241/20
CPC分类号： C07D241/26 , C07D401/12 , C07D403/12
摘要： A compound of Formula I or a hydrate or solvate thereof, where R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 have the meanings as indicated in the specification, is useful for treating diseases which respond to the blockade of the epithelial sodium channel. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
摘要翻译： 式I化合物或其水合物或溶剂化物，其中R1，R2，R3，R4，R5，R6，R7，R8，R9和R10具有说明书中所示的含义，可用于治疗对 阻断上皮钠通道。 还描述了含有化合物的药物组合物和用于制备化合物的方法。
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公开(公告)号：US20110201625A1
公开(公告)日：2011-08-18
申请号：US12995647
申请日：2009-06-08
申请人： Stephen Paul Collingwood , Nicholas James Devereux , Catherine Howsham , Peter Hunt , Thomas Anthony Hunt
发明人： Stephen Paul Collingwood , Nicholas James Devereux , Catherine Howsham , Peter Hunt , Thomas Anthony Hunt
IPC分类号： A61K31/4965 , C07D241/20 , A61K31/497 , A61P29/00 , A61P37/08 , A61P11/00
CPC分类号： C07D241/26 , C07D401/12 , C07D403/12
摘要： A compound of Formula I or a hydrate or solvate thereof, where R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 have the meanings as indicated in the specification, is useful for treating diseases which respond to the blockade of the epithelial sodium channel. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
摘要翻译： 式I化合物或其水合物或溶剂化物，其中R1，R2，R3，R4，R5，R6，R7，R8，R9和R10具有说明书中所示的含义，可用于治疗对 阻断上皮钠通道。 还描述了含有化合物的药物组合物和用于制备化合物的方法。
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公开(公告)号：US20100041887A1
公开(公告)日：2010-02-18
申请号：US12582291
申请日：2009-10-20
IPC分类号： C07D453/02
CPC分类号： C07D453/02
摘要： Compounds of formula I in salt or zwitterionic form wherein, wherein R1, R2, R3, and R4 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by the muscarinic M3 receptor. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.
摘要翻译： 盐或两性离子形式的式I化合物，其中R1，R2，R3和R4具有说明书中所示的含义，可用于治疗由毒蕈碱M3受体介导的病症。 还描述了含有化合物的药物组合物和制备该化合物的方法。
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