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1.发明申请Agents Useful for Reducing Amyloid Precursor Protein and Treating Dementia and Methods of Use Thereof 有权可用于降低淀粉样蛋白前体蛋白和治疗痴呆的药剂及其使用方法公开(公告)号：US20110021594A1
公开(公告)日：2011-01-27
申请号：US12841888
申请日：2010-07-22
申请人： Nigel H. Greig , Karen T.Y. Shaw , Qiang-Sheng Yu , Harold W. Holloway , Tada Utsuki , Timothy T. Soncrant , Donald K. Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane Davidson , Michael Sturgess
发明人： Nigel H. Greig , Karen T.Y. Shaw , Qiang-Sheng Yu , Harold W. Holloway , Tada Utsuki , Timothy T. Soncrant , Donald K. Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane Davidson , Michael Sturgess
IPC分类号： A61K31/407 , A61P25/28
CPC分类号： C07D487/04 , A61K31/325 , A61K31/343 , A61K31/345 , A61K31/381 , A61K31/382 , A61K31/403 , A61K31/405 , A61K31/407 , C07D209/16 , C07D209/34 , C07D209/36 , C07D209/38 , C07D277/82 , C07D453/04 , C07D471/04 , C07D487/08 , C07D491/04 , C07D495/04
摘要： The present invention provides compounds and methods of administering compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. The present invention also provides non-carbamate compounds and methods of administering such compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. It has been discovered that either the racemic or enantiomerically pure non-carbamate compounds can be used to decrease βAPP production.
摘要翻译： 本发明提供了向受试者施用化合物和方法，所述方法可以减少和产生APP，并且在广泛的剂量范围内是无毒的。 本发明还提供了非氨基甲酸酯化合物和向受试者施用此类化合物的方法，所述方法可以减少APP生产并且在广泛剂量范围内不具有毒性。 已经发现外消旋或对映体纯的非氨基甲酸酯化合物可用于减少和生产APP生产。
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2.发明申请Agents Useful for Reducing Amyloid Precursor Protein and Treating Dementia and Methods of Use Thereof 有权可用于降低淀粉样蛋白前体蛋白和治疗痴呆的药剂及其使用方法公开(公告)号：US20090131501A1
公开(公告)日：2009-05-21
申请号：US12357115
申请日：2009-01-21
申请人： Nigel H. Greig , Karen T.Y. Shaw , Qiang-Sheng Yu , Harold W. Holloway , Tada Utsuki , Timothy T. Soncrant , Donald K. Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane Davidson , Michael Sturgess
发明人： Nigel H. Greig , Karen T.Y. Shaw , Qiang-Sheng Yu , Harold W. Holloway , Tada Utsuki , Timothy T. Soncrant , Donald K. Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane Davidson , Michael Sturgess
IPC分类号： A61K31/407 , A61P25/28
CPC分类号： C07D487/04 , A61K31/325 , A61K31/343 , A61K31/345 , A61K31/381 , A61K31/382 , A61K31/403 , A61K31/405 , A61K31/407 , C07D209/16 , C07D209/34 , C07D209/36 , C07D209/38 , C07D277/82 , C07D453/04 , C07D471/04 , C07D487/08 , C07D491/04 , C07D495/04
摘要： The present invention provides compounds and methods of administering compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. The present invention also provides non-carbamate compounds and methods of administering such compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. It has been discovered that either the racemic or enantiomerically pure non-carbamate compounds can be used to decrease βAPP production.
摘要翻译： 本发明提供了向受试者施用可以降低βAPP产生并且在广泛剂量范围内无毒性的化合物和方法。 本发明还提供了非氨基甲酸酯化合物和向可以减少βAPP产生并且在广泛剂量范围内无毒性的受试者施用此类化合物的方法。 已经发现外消旋或对映异构体纯的非氨基甲酸酯化合物可用于降低βAPP产生。
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3.发明授权Agents useful for reducing amyloid precursor protein and treating demantia and methods of use thereof 有权可用于减少淀粉样蛋白前体蛋白和治疗消瘦的药剂及其使用方法公开(公告)号：US07153882B2
公开(公告)日：2006-12-26
申请号：US10415765
申请日：2001-11-02
申请人： Nigel H. Greig , Karen T. Y. Shaw , Qiang-Sheng Yu , Harold W. Holloway , Timothy T. Sencrant , Tada Utsuki , Donald Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane Davidson , Michael Sturgess
发明人： Nigel H. Greig , Karen T. Y. Shaw , Qiang-Sheng Yu , Harold W. Holloway , Timothy T. Sencrant , Tada Utsuki , Donald Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane Davidson , Michael Sturgess
IPC分类号： A61K31/40 , C07D487/02 , C07D491/02
CPC分类号： C07D487/04 , A61K31/325 , A61K31/343 , A61K31/345 , A61K31/381 , A61K31/382 , A61K31/403 , A61K31/405 , A61K31/407 , C07D209/16 , C07D209/34 , C07D209/36 , C07D209/38 , C07D277/82 , C07D453/04 , C07D471/04 , C07D487/08 , C07D491/04 , C07D495/04
摘要： The present invention provides compounds and methods of administering compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. The present invention also provides non-carbamate compounds and methods of administering such compounds to a subject that can reduce βAPP production and that is not tocix in a wide range of dosages. It has been discovered that either the racemic or enantiomerically pure non-carbamate compounds can be used to decrease βAPP production.
摘要翻译： 本发明提供了向受试者施用可以降低βAPP产生并且在广泛剂量范围内无毒性的化合物和方法。 本发明还提供了非氨基甲酸酯化合物和向可以减少βAPP产生的受试者施用这种化合物的方法，并且在广泛的剂量范围内不是曲线。 已经发现外消旋或对映异构体纯的非氨基甲酸酯化合物可用于降低βAPP产生。
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4.发明申请Agents useful for reducing amylioid precursor protein and treating dementia and methods of use thereof 审中-公开可用于还原淀粉样蛋白前体蛋白和治疗痴呆的药剂及其使用方法公开(公告)号：US20060270729A1
公开(公告)日：2006-11-30
申请号：US11455959
申请日：2006-06-20
申请人： Nigel Greig , Karen Shaw , Qiang-Sheng Yu , Harold Holloway , Tada Utsuki , Timothy Soncrant , Donald Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane Davidson , Michael Sturgess
发明人： Nigel Greig , Karen Shaw , Qiang-Sheng Yu , Harold Holloway , Tada Utsuki , Timothy Soncrant , Donald Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane Davidson , Michael Sturgess
IPC分类号： A61K31/407 , A61K31/405 , A61K31/381 , A61K31/343
CPC分类号： C07D487/04 , A61K31/325 , A61K31/343 , A61K31/345 , A61K31/381 , A61K31/382 , A61K31/403 , A61K31/405 , A61K31/407 , C07D209/16 , C07D209/34 , C07D209/36 , C07D209/38 , C07D277/82 , C07D453/04 , C07D471/04 , C07D487/08 , C07D491/04 , C07D495/04
摘要： The present invention provides compounds and methods of administering compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. The present invention also provides non-carbamate compounds and methods of administering such compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. It has been discovered that either the racemic or enantiomerically pure non-carbamate compounds can be used to decrease βAPP production.
摘要翻译： 本发明提供了向受试者施用可以降低βAPP产生并且在广泛剂量范围内无毒性的化合物和方法。 本发明还提供了非氨基甲酸酯化合物和向可以减少βAPP产生并且在广泛剂量范围内无毒性的受试者施用此类化合物的方法。 已经发现外消旋或对映异构体纯的非氨基甲酸酯化合物可用于降低βAPP产生。
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公开(公告)号：US20190069345A1
公开(公告)日：2019-02-28
申请号：US15689280
申请日：2017-08-29
申请人： Diane Davidson
发明人： Diane Davidson
摘要： A wax warming machine may removably retain and warm numerous cans of wax cans, enabling safe and sanitary multiple depilatory treatments and a hygienic waxing experience. The present invention may provide that the wax warming device may comprise a pedestal base, at least one heating component, a housing, a toggle switch, a heat adjustment dial, an indicator light, a heating surface, at least one can of wax, and power chord.
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