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1.发明申请Agents Useful for Reducing Amyloid Precursor Protein and Treating Dementia and Methods of Use Thereof 有权可用于降低淀粉样蛋白前体蛋白和治疗痴呆的药剂及其使用方法公开(公告)号：US20110021594A1
公开(公告)日：2011-01-27
申请号：US12841888
申请日：2010-07-22
申请人： Nigel H. Greig , Karen T.Y. Shaw , Qiang-Sheng Yu , Harold W. Holloway , Tada Utsuki , Timothy T. Soncrant , Donald K. Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane Davidson , Michael Sturgess
发明人： Nigel H. Greig , Karen T.Y. Shaw , Qiang-Sheng Yu , Harold W. Holloway , Tada Utsuki , Timothy T. Soncrant , Donald K. Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane Davidson , Michael Sturgess
IPC分类号： A61K31/407 , A61P25/28
CPC分类号： C07D487/04 , A61K31/325 , A61K31/343 , A61K31/345 , A61K31/381 , A61K31/382 , A61K31/403 , A61K31/405 , A61K31/407 , C07D209/16 , C07D209/34 , C07D209/36 , C07D209/38 , C07D277/82 , C07D453/04 , C07D471/04 , C07D487/08 , C07D491/04 , C07D495/04
摘要： The present invention provides compounds and methods of administering compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. The present invention also provides non-carbamate compounds and methods of administering such compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. It has been discovered that either the racemic or enantiomerically pure non-carbamate compounds can be used to decrease βAPP production.
摘要翻译： 本发明提供了向受试者施用化合物和方法，所述方法可以减少和产生APP，并且在广泛的剂量范围内是无毒的。 本发明还提供了非氨基甲酸酯化合物和向受试者施用此类化合物的方法，所述方法可以减少APP生产并且在广泛剂量范围内不具有毒性。 已经发现外消旋或对映体纯的非氨基甲酸酯化合物可用于减少和生产APP生产。
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2.发明申请Agents Useful for Reducing Amyloid Precursor Protein and Treating Dementia and Methods of Use Thereof 有权可用于降低淀粉样蛋白前体蛋白和治疗痴呆的药剂及其使用方法公开(公告)号：US20090131501A1
公开(公告)日：2009-05-21
申请号：US12357115
申请日：2009-01-21
申请人： Nigel H. Greig , Karen T.Y. Shaw , Qiang-Sheng Yu , Harold W. Holloway , Tada Utsuki , Timothy T. Soncrant , Donald K. Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane Davidson , Michael Sturgess
发明人： Nigel H. Greig , Karen T.Y. Shaw , Qiang-Sheng Yu , Harold W. Holloway , Tada Utsuki , Timothy T. Soncrant , Donald K. Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane Davidson , Michael Sturgess
IPC分类号： A61K31/407 , A61P25/28
CPC分类号： C07D487/04 , A61K31/325 , A61K31/343 , A61K31/345 , A61K31/381 , A61K31/382 , A61K31/403 , A61K31/405 , A61K31/407 , C07D209/16 , C07D209/34 , C07D209/36 , C07D209/38 , C07D277/82 , C07D453/04 , C07D471/04 , C07D487/08 , C07D491/04 , C07D495/04
摘要： The present invention provides compounds and methods of administering compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. The present invention also provides non-carbamate compounds and methods of administering such compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. It has been discovered that either the racemic or enantiomerically pure non-carbamate compounds can be used to decrease βAPP production.
摘要翻译： 本发明提供了向受试者施用可以降低βAPP产生并且在广泛剂量范围内无毒性的化合物和方法。 本发明还提供了非氨基甲酸酯化合物和向可以减少βAPP产生并且在广泛剂量范围内无毒性的受试者施用此类化合物的方法。 已经发现外消旋或对映异构体纯的非氨基甲酸酯化合物可用于降低βAPP产生。
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3.发明申请Agents Useful for Reducing Amyloid Precursor Protein and Treating Dementia and Methods of Use Thereof 失效可用于降低淀粉样蛋白前体蛋白和治疗痴呆的药剂及其使用方法公开(公告)号：US20120295946A1
公开(公告)日：2012-11-22
申请号：US13559186
申请日：2012-07-26
申请人： Nigel H. Greig , Karen T.Y. Shaw , Qiang-Sheng Yu , Harold W. Holloway , Tada Utsuki , Timothy T. Soncrant , Donald K. Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane M. Davidson , Michael Sturgess
发明人： Nigel H. Greig , Karen T.Y. Shaw , Qiang-Sheng Yu , Harold W. Holloway , Tada Utsuki , Timothy T. Soncrant , Donald K. Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane M. Davidson , Michael Sturgess
IPC分类号： A61K31/407 , A61P25/28
CPC分类号： C07D487/04 , A61K31/325 , A61K31/343 , A61K31/345 , A61K31/381 , A61K31/382 , A61K31/403 , A61K31/405 , A61K31/407 , C07D209/16 , C07D209/34 , C07D209/36 , C07D209/38 , C07D277/82 , C07D453/04 , C07D471/04 , C07D487/08 , C07D491/04 , C07D495/04
摘要： The present invention provides compounds and methods of administering compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. The present invention also provides non-carbamate compounds and methods of administering such compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. It has been discovered that either the racemic or enantiomerically pure non-carbamate compounds can be used to decrease βAPP production.
摘要翻译： 本发明提供了向受试者施用化合物和方法，所述方法可以减少和产生APP，并且在广泛的剂量范围内是无毒的。 本发明还提供了非氨基甲酸酯化合物和向受试者施用此类化合物的方法，所述方法可以减少APP生产并且在广泛剂量范围内不具有毒性。 已经发现外消旋或对映体纯的非氨基甲酸酯化合物可用于减少和生产APP生产。
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4.发明授权Agents useful for reducing amyloid precursor protein and treating dementia and methods of use thereof 失效可用于降低淀粉样蛋白前体蛋白和治疗痴呆的药剂及其使用方法公开(公告)号：US08691864B2
公开(公告)日：2014-04-08
申请号：US13559186
申请日：2012-07-26
申请人： Nigel H. Greig , Karen T. Y. Shaw , Qiang-Sheng Yu , Harold W. Holloway , Tada Utsuki , Timothy T. Soncrant , Donald K. Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane M. Davidson , Michael Sturgess
发明人： Nigel H. Greig , Karen T. Y. Shaw , Qiang-Sheng Yu , Harold W. Holloway , Tada Utsuki , Timothy T. Soncrant , Donald K. Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane M. Davidson , Michael Sturgess
IPC分类号： A61K31/40
CPC分类号： C07D487/04 , A61K31/325 , A61K31/343 , A61K31/345 , A61K31/381 , A61K31/382 , A61K31/403 , A61K31/405 , A61K31/407 , C07D209/16 , C07D209/34 , C07D209/36 , C07D209/38 , C07D277/82 , C07D453/04 , C07D471/04 , C07D487/08 , C07D491/04 , C07D495/04
摘要： The present invention provides compounds and methods of administering compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. The present invention also provides non-carbamate compounds and methods of administering such compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. It has been discovered that either the racemic or enantiomerically pure non-carbamate compounds can be used to decrease βAPP production.
摘要翻译： 本发明提供了向受试者施用化合物和方法，所述方法可以减少和产生APP，并且在广泛的剂量范围内是无毒的。 本发明还提供了非氨基甲酸酯化合物和向受试者施用此类化合物的方法，所述方法可以减少APP生产并且在广泛剂量范围内不具有毒性。 已经发现外消旋或对映体纯的非氨基甲酸酯化合物可用于减少和生产APP生产。
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5.发明授权Agents useful for reducing amyloid precursor protein and treating dementia and methods of use thereof 有权可用于降低淀粉样蛋白前体蛋白和治疗痴呆的药剂及其使用方法公开(公告)号：US08258172B2
公开(公告)日：2012-09-04
申请号：US12841888
申请日：2010-07-22
申请人： Nigel H. Greig , Karen T. Y. Shaw , Qiang-Sheng Yu , Harold W. Holloway , Tada Utsuki , Timothy T. Soncrant , Donald K. Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane M. Davidson , Michael Sturgess
发明人： Nigel H. Greig , Karen T. Y. Shaw , Qiang-Sheng Yu , Harold W. Holloway , Tada Utsuki , Timothy T. Soncrant , Donald K. Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane M. Davidson , Michael Sturgess
IPC分类号： A61K31/40
CPC分类号： C07D487/04 , A61K31/325 , A61K31/343 , A61K31/345 , A61K31/381 , A61K31/382 , A61K31/403 , A61K31/405 , A61K31/407 , C07D209/16 , C07D209/34 , C07D209/36 , C07D209/38 , C07D277/82 , C07D453/04 , C07D471/04 , C07D487/08 , C07D491/04 , C07D495/04
摘要： The present invention provides compounds and methods of administering compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. The present invention also provides non-carbamate compounds and methods of administering such compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. It has been discovered that either the racemic or enantiomerically pure non-carbamate compounds can be used to decrease βAPP production.
摘要翻译： 本发明提供了向受试者施用化合物和方法，所述方法可以减少和产生APP，并且在广泛的剂量范围内是无毒的。 本发明还提供了非氨基甲酸酯化合物和向受试者施用此类化合物的方法，所述方法可以减少APP生产并且在广泛剂量范围内不具有毒性。 已经发现外消旋或对映体纯的非氨基甲酸酯化合物可用于减少和生产APP生产。
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6.发明授权Agents useful for reducing amyloid precursor protein and treating dementia and methods of use thereof 有权可用于降低淀粉样蛋白前体蛋白和治疗痴呆的药剂及其使用方法公开(公告)号：US07786162B2
公开(公告)日：2010-08-31
申请号：US12357115
申请日：2009-01-21
申请人： Nigel H. Greig , Karen T. Y. Shaw , Qiang-Sheng Yu , Harold W. Holloway , Tada Utsuki , Timothy T. Soncrant , Donald K. Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane M. Davidson , Michael Sturgess
发明人： Nigel H. Greig , Karen T. Y. Shaw , Qiang-Sheng Yu , Harold W. Holloway , Tada Utsuki , Timothy T. Soncrant , Donald K. Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane M. Davidson , Michael Sturgess
IPC分类号： A61K31/40 , C07D487/00
CPC分类号： C07D487/04 , A61K31/325 , A61K31/343 , A61K31/345 , A61K31/381 , A61K31/382 , A61K31/403 , A61K31/405 , A61K31/407 , C07D209/16 , C07D209/34 , C07D209/36 , C07D209/38 , C07D277/82 , C07D453/04 , C07D471/04 , C07D487/08 , C07D491/04 , C07D495/04
摘要： The present invention provides compounds and methods of administering compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. The present invention also provides non-carbamate compounds and methods of administering such compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. It has been discovered that either the racemic or enantiomerically pure non-carbamate compounds can be used to decrease βAPP production.
摘要翻译： 本发明提供了向受试者施用化合物和方法，所述方法可以减少和产生APP，并且在广泛的剂量范围内是无毒的。 本发明还提供了非氨基甲酸酯化合物和向受试者施用此类化合物的方法，所述方法可以减少APP生产并且在广泛剂量范围内不具有毒性。 已经发现外消旋或对映体纯的非氨基甲酸酯化合物可用于减少和生产APP生产。
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7.发明授权Agents useful for reducing amyloid precursor protein and treating demantia and methods of use thereof 有权可用于减少淀粉样蛋白前体蛋白和治疗消瘦的药剂及其使用方法公开(公告)号：US07153882B2
公开(公告)日：2006-12-26
申请号：US10415765
申请日：2001-11-02
申请人： Nigel H. Greig , Karen T. Y. Shaw , Qiang-Sheng Yu , Harold W. Holloway , Timothy T. Sencrant , Tada Utsuki , Donald Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane Davidson , Michael Sturgess
发明人： Nigel H. Greig , Karen T. Y. Shaw , Qiang-Sheng Yu , Harold W. Holloway , Timothy T. Sencrant , Tada Utsuki , Donald Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane Davidson , Michael Sturgess
IPC分类号： A61K31/40 , C07D487/02 , C07D491/02
CPC分类号： C07D487/04 , A61K31/325 , A61K31/343 , A61K31/345 , A61K31/381 , A61K31/382 , A61K31/403 , A61K31/405 , A61K31/407 , C07D209/16 , C07D209/34 , C07D209/36 , C07D209/38 , C07D277/82 , C07D453/04 , C07D471/04 , C07D487/08 , C07D491/04 , C07D495/04
摘要： The present invention provides compounds and methods of administering compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. The present invention also provides non-carbamate compounds and methods of administering such compounds to a subject that can reduce βAPP production and that is not tocix in a wide range of dosages. It has been discovered that either the racemic or enantiomerically pure non-carbamate compounds can be used to decrease βAPP production.
摘要翻译： 本发明提供了向受试者施用可以降低βAPP产生并且在广泛剂量范围内无毒性的化合物和方法。 本发明还提供了非氨基甲酸酯化合物和向可以减少βAPP产生的受试者施用这种化合物的方法，并且在广泛的剂量范围内不是曲线。 已经发现外消旋或对映异构体纯的非氨基甲酸酯化合物可用于降低βAPP产生。
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公开(公告)号：US5409948A
公开(公告)日：1995-04-25
申请号：US980399
申请日：1992-11-23
申请人： Nigel H. Greig , Arnold Brossi , Timothy T. Soncrant , Harold W. Holloway , Stanley I. Rapoport , Setsu Iijima , Edward L. Spangler , Donald K. Ingram , Xue F. Pei
发明人： Nigel H. Greig , Arnold Brossi , Timothy T. Soncrant , Harold W. Holloway , Stanley I. Rapoport , Setsu Iijima , Edward L. Spangler , Donald K. Ingram , Xue F. Pei
IPC分类号： C07D487/04 , A61K31/40 , A61P25/28
CPC分类号： A61K31/40
摘要： An improved method of cholinomimetic therapy for cognitive impairments associated with aging and Alzheimer's disease comprising treating a patient with an effective amount of phenserine or a pharmaceutically acceptable salt and derivatives.
摘要翻译： 一种用于与老化和阿尔茨海默氏病相关的认知障碍的改善的胆碱模拟治疗方法，其包括用有效量的苯丝氨酸或其药学上可接受的盐和衍生物治疗患者。
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公开(公告)号：US20130143922A1
公开(公告)日：2013-06-06
申请号：US13310242
申请日：2011-12-02
申请人： Nigel H. Greig , Weiming Luo , David Tweedie , Harold W. Holloway , Qian-Sheng Yu , Edward J. Goetzl
发明人： Nigel H. Greig , Weiming Luo , David Tweedie , Harold W. Holloway , Qian-Sheng Yu , Edward J. Goetzl
IPC分类号： A61K31/454 , A61P25/28 , A61P25/16 , A61P27/02 , A61P19/02 , A61P25/14 , A61P25/02 , C07D401/04 , A61P29/00
CPC分类号： A61K31/454 , C07D401/04 , Y02A50/411
摘要： A compound, or a pharmaceutically acceptable salt or ester thereof, having a structure of: wherein A, B and D are each oxygen or sulfur, provided that least one of A, B and D is sulfur; and R1-R8 are each independently hydrogen, hydroxyl, acyl, substituted acyl, acyloxy, substituted acyloxy, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, alkoxy, substituted alkoxy, aryl, substituted aryl, amino, substituted amino, halogen, heterocycloalkyl, substituted heterocycloalkyl, heteroaryl, substituted heteroaryl, or a thio-containing group.
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公开(公告)号：US08927725B2
公开(公告)日：2015-01-06
申请号：US13310242
申请日：2011-12-02
申请人： Nigel H. Greig , Weiming Luo , David Tweedie , Harold W. Holloway , Qian-Sheng Yu , Edward J. Goetzl
发明人： Nigel H. Greig , Weiming Luo , David Tweedie , Harold W. Holloway , Qian-Sheng Yu , Edward J. Goetzl
IPC分类号： C07D401/00 , A61K31/44
CPC分类号： A61K31/454 , C07D401/04 , Y02A50/411
摘要： A compound, or a pharmaceutically acceptable salt or ester thereof, having a structure of: wherein A, B and D are each oxygen or sulfur, provided that least one of A, B and D is sulfur; and R1-R8 are each independently hydrogen, hydroxyl, acyl, substituted acyl, acyloxy, substituted acyloxy, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, alkoxy, substituted alkoxy, aryl, substituted aryl, amino, substituted amino, halogen, heterocycloalkyl, substituted heterocycloalkyl, heteroaryl, substituted heteroaryl, or a thio-containing group.
摘要翻译： 具有以下结构的化合物或其药学上可接受的盐或酯：其中A，B和D各自为氧或硫，条件是A，B和D中的至少一个为硫; 取代的烷基，烯基，取代的烯基，炔基，取代的炔基，烷氧基，取代的烷氧基，芳基，取代的芳基，氨基，取代的氨基 ，卤素，杂环烷基，取代的杂环烷基，杂芳基，取代的杂芳基或含硫基团。
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