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1.发明申请Tetrahydrobenzo(D)Azepin-2-One Derivatives and the Use Thereof for Treating Cardiovascular Diseases 失效四氢苯并（D）Azepin-2-One衍生物及其用途治疗心血管疾病公开(公告)号：US20070287698A1
公开(公告)日：2007-12-13
申请号：US10588862
申请日：2005-02-01
申请人： Nils Griebenow , Timo Flessner , Michael Harter , Martin Raabe , Anja Buchmuller , Hilmar Bischoff , Peter Ellinghaus , Peter Kolkhof
发明人： Nils Griebenow , Timo Flessner , Michael Harter , Martin Raabe , Anja Buchmuller , Hilmar Bischoff , Peter Ellinghaus , Peter Kolkhof
IPC分类号： A61K31/55 , A61P9/00 , C07D223/16
CPC分类号： C07D223/16 , C07D401/06
摘要： The present application relates to novel tetrahydrobenzo[d]azepin-2-one derivatives, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders, especially of dyslipidaemias, arteriosclerosis, restenosis and ischaemias.
摘要翻译： 本申请涉及新的四氢苯并[d]吖庚因-2-酮衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途， 优选用于治疗和/或预防心血管疾病，特别是血脂异常，动脉硬化，再狭窄和缺血性疾病。
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公开(公告)号：US20090215743A1
公开(公告)日：2009-08-27
申请号：US10586023
申请日：2004-12-31
申请人： Elisabeth Woltering , Michael Härter , Timo Flessner , Mario Jeske , Nils Griebenow , Frank Süssmeier , Hilmar Bischoff , Martin Raabe , Anja Buchmüller , Peter Kolkhof , Peter Ellinghaus , Olaf Weber
发明人： Elisabeth Woltering , Michael Härter , Timo Flessner , Mario Jeske , Nils Griebenow , Frank Süssmeier , Hilmar Bischoff , Martin Raabe , Anja Buchmüller , Peter Kolkhof , Peter Ellinghaus , Olaf Weber
IPC分类号： A61K31/5383 , C07D498/04
CPC分类号： C07D498/04
摘要： The present application relates to novel tricyclic benzazepine derivatives, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders, especially of dyslipidaemias, arteriosclerosis, restenosis and ischaemias.
摘要翻译： 本申请涉及新型三环苯并氮杂衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于治疗和/或预防疾病的药物的用途，优选用于治疗和/或 预防心血管疾病，特别是血脂异常，动脉硬化，再狭窄和局部缺血。
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![Tetrahydrobenzo[d]azepin-2-one derivatives and the use thereof for treating cardiovascular diseases](/abs-image/US/2010/02/16/US07662956B2/abs.jpg.150x150.jpg)
3.发明授权Tetrahydrobenzo[d]azepin-2-one derivatives and the use thereof for treating cardiovascular diseases 失效四氢苯并[d]吖庚因-2-酮衍生物及其用于治疗心血管疾病的用途公开(公告)号：US07662956B2
公开(公告)日：2010-02-16
申请号：US10588862
申请日：2005-02-01
申请人： Nils Griebenow , Timo Flessner , Michael Härter , Martin Raabe , Anja Buchmüller , Hilmar Bischoff , Peter Ellinghaus , Peter Kolkhof
发明人： Nils Griebenow , Timo Flessner , Michael Härter , Martin Raabe , Anja Buchmüller , Hilmar Bischoff , Peter Ellinghaus , Peter Kolkhof
IPC分类号： C07D233/16 , A61K31/55
CPC分类号： C07D223/16 , C07D401/06
摘要： The present application relates to novel tetrahydrobenzo[d]azepin-2-one derivatives, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders, especially of dyslipidaemias, arteriosclerosis, restenosis and ischaemias.
摘要翻译： 本申请涉及新的四氢苯并[d]吖庚因-2-酮衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途， 优选用于治疗和/或预防心血管疾病，特别是血脂异常，动脉硬化，再狭窄和缺血性疾病。
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公开(公告)号：US20120258964A1
公开(公告)日：2012-10-11
申请号：US13412946
申请日：2012-03-06
申请人： Joachim Luithle , Frank-Gerhard Böss , Christina Erb , Frank-Thorsten Hafner , Katrin Schnizler , Timo Flessner , Marja Van Kampen , Franz-Josef Van Der Staay
发明人： Joachim Luithle , Frank-Gerhard Böss , Christina Erb , Frank-Thorsten Hafner , Katrin Schnizler , Timo Flessner , Marja Van Kampen , Franz-Josef Van Der Staay
IPC分类号： C07D453/02 , A61K31/5377 , A61P25/28 , A61K31/506 , A61P25/00 , A61K31/439 , A61K31/496
CPC分类号： C07D453/02
摘要： The invention relates to novel 2-heteroaryl carboxamides and to the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning and/or memory.
摘要翻译： 本发明涉及新的2-杂芳基羧酰胺及其用于制备用于治疗和/或预防疾病和改善感知，浓度，学习和/或记忆的药物的用途。
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公开(公告)号：US08030329B2
公开(公告)日：2011-10-04
申请号：US12099108
申请日：2008-04-07
申请人： Timo Flessner , Frank-Gerhard Böss , Frank-Thorsten Hafner , Joachim Luithle , Christoph Methfessel , Leila Telan
发明人： Timo Flessner , Frank-Gerhard Böss , Frank-Thorsten Hafner , Joachim Luithle , Christoph Methfessel , Leila Telan
CPC分类号： A61K31/439 , A61K45/06 , C07D453/02
摘要： The invention relates to N-biarylamides useful for the prophylaxis and/or treatment of impairments of perception, concentration, learning and/or memory, and to processes for preparing them, and pharmaceutical compositions containing them.
摘要翻译： 本发明涉及可用于预防和/或治疗感知，浓度，学习和/或记忆障碍的N-二芳基酰胺及其制备方法，以及含有它们的药物组合物。
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6.发明授权Azabicyclic carbamates and their use as alpha-7 nicotinic acetylcholine receptor agonists 有权氮杂双环氨基甲酸酯及其作为α-7烟碱乙酰胆碱受体激动剂的用途公开(公告)号：US08153799B2
公开(公告)日：2012-04-10
申请号：US12871495
申请日：2010-08-30
申请人： Timo Flessner , Frank-Gerhard Boss , Christina Erb , Frank-Thorsten Hafner , Katrin Schnizler , Dieter Lang , Joachim Luithle , Marja Van Kampen , Franz-Josef Van Der Staay
发明人： Timo Flessner , Frank-Gerhard Boss , Christina Erb , Frank-Thorsten Hafner , Katrin Schnizler , Dieter Lang , Joachim Luithle , Marja Van Kampen , Franz-Josef Van Der Staay
IPC分类号： C07D453/02 , C07D307/00
CPC分类号： C07D453/02
摘要： The invention relates to novel benzothiophene-, benzofuran-, and indole ureas and to the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning, and/or memory.
摘要翻译： 本发明涉及新的苯并噻吩 - ，苯并呋喃和吲哚脲，以及其用于制备用于治疗和/或预防疾病和改善感知，集中，学习和/或记忆的药物的用途。
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公开(公告)号：US20110263591A1
公开(公告)日：2011-10-27
申请号：US13179957
申请日：2011-07-11
申请人： Joachim Luithle , Frank-Gerhard Böss , Christina Erb , Frank-Thorsten Hafner , Katrin Schnizler , Timo Flessner , Marja van Kampen , Franz-Josef van der Staay
发明人： Joachim Luithle , Frank-Gerhard Böss , Christina Erb , Frank-Thorsten Hafner , Katrin Schnizler , Timo Flessner , Marja van Kampen , Franz-Josef van der Staay
IPC分类号： A61K31/439 , A61K31/506 , A61P25/28 , A61K31/5377
CPC分类号： C07D453/02
摘要： The invention relates to novel 2-heteroaryl carboxamides and to the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning and/or memory.
摘要翻译： 本发明涉及新的2-杂芳基羧酰胺及其用于制备用于治疗和/或预防疾病和改善感知，浓度，学习和/或记忆的药物的用途。
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8.发明申请AZABICYCLIC CARBAMATES AND THEIR USE AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR AGONISTS 有权异丁烯酸碳酸酯及其作为ALPHA-7 NICOTINIC乙酰胆碱受体激动剂公开(公告)号：US20100324085A1
公开(公告)日：2010-12-23
申请号：US12871495
申请日：2010-08-30
申请人： Timo Flessner , Frank-Gerhard Böss , Christina Erb , Frank-Thorsten Hafner , Katrin Schnizler , Dieter Lang , Joachim Luithle , Maria-Van Kampen , Franz-Josef Van der Staay
发明人： Timo Flessner , Frank-Gerhard Böss , Christina Erb , Frank-Thorsten Hafner , Katrin Schnizler , Dieter Lang , Joachim Luithle , Maria-Van Kampen , Franz-Josef Van der Staay
IPC分类号： A61K31/4375 , C07D453/02 , A61P25/00
CPC分类号： C07D453/02
摘要： The invention relates to novel benzothiophene-, benzofuran-, and indole ureas and to the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning, and/or memory.
摘要翻译： 本发明涉及新的苯并噻吩 - ，苯并呋喃和吲哚脲，以及其用于制备用于治疗和/或预防疾病和改善感知，集中，学习和/或记忆的药物的用途。
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公开(公告)号：US20070112023A1
公开(公告)日：2007-05-17
申请号：US10565181
申请日：2004-07-19
申请人： Timo Flessner , Frank-Gerhard Boss , Frank-Thorsten Hafner , Joachim Luithle , Christoph Methfessel , Leila Telan
发明人： Timo Flessner , Frank-Gerhard Boss , Frank-Thorsten Hafner , Joachim Luithle , Christoph Methfessel , Leila Telan
IPC分类号： A61K31/4745 , C07D453/02
CPC分类号： A61K31/439 , A61K45/06 , C07D453/02
摘要： The invention relates to N-biarylamides, methods for production and use thereof for the production of medicaments for the treatment and/or prophylaxis of diseases and for improvement in cognition, concentration power, learning power and/or memory.
摘要翻译： 本发明涉及N-二芳基酰胺，其生产和使用方法，用于生产用于治疗和/或预防疾病和改善认知，集中力，学习能力和/或记忆力的药物。
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公开(公告)号：US20050107460A1
公开(公告)日：2005-05-19
申请号：US10497511
申请日：2002-12-06
申请人： Joachim Luithle , Frank-Gerhard Boss , Christina Erb , Timo Flessner , Martin Hendrix , Marja Kampen , Christoph Methfessel
发明人： Joachim Luithle , Frank-Gerhard Boss , Christina Erb , Timo Flessner , Martin Hendrix , Marja Kampen , Christoph Methfessel
IPC分类号： A61K31/435 , A61K31/439 , A61K31/4709 , A61K31/498 , A61P25/28 , A61P43/00 , C07D453/02 , A61K31/33 , A61K31/407 , C07D471/02
CPC分类号： A61K31/435 , C07D453/02
摘要： The invention relates to novel bicylic N-arylamides, to a method for the production thereof, and to the use of the same for producing pharmaceuticals for the treatment and/or prophylaxis of diseases and for improving perception, power of concentration, learnig capacity and/or memory retention.
摘要翻译： 本发明涉及新型的二元N-芳基酰胺，其制备方法及其用途，用于制备药物用于治疗和/或预防疾病，以及改善感知，集中力，学习能力和/ 或记忆保留。
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