公开(公告)号：US11851692B2

公开(公告)日：2023-12-26

申请号：US18127674

申请日：2023-03-29

Applicant: Ningbo University

Inventor： Lijian Ding ,  Shan He ,  Wenhao Li ,  Weiyan Zhang ,  Yingying Wei

IPC: C12P17/08 ,  C07D321/00

CPC classification number: C12P17/08 ,  C07D321/00

Abstract: Disclosed are an antimycin compound and a preparation method and use thereof. The preparation method comprises: fermenting a marine actinomycete (Streptomyces sp.4-7) with a preservation number CCTCCNO: M2020953 to obtain a fermented product and soaking and extracting the fermented product with ethyl acetate to obtain a crude extract; and carrying out separation and purification by normal-phase silica gel column chromatography, reversed-phase MPLC, and semi-preparative reversed-phase high-performance liquid chromatography. The invention has the advantages of resistance against Botrytis cinerea and Penicillium citrinum.