公开(公告)号：US06297043B1

公开(公告)日：2001-10-02

申请号：US09338601

申请日：1999-06-23

申请人： Nirogi Venkata Satya Ramakrishna ,  Keshavapura Hosamane Sreedhara Swamy ,  Erra Koteswara Satya Vijaya Kumar ,  Manoj Maniram Singh Kushwaha ,  Sridevi Kota ,  Mythili Raman ,  Swati Dhananjay Tare ,  Sunil Kumar Deshmukh ,  Dietmar Schummer ,  Michael Kurz ,  Herbert Kogler

发明人： Nirogi Venkata Satya Ramakrishna ,  Keshavapura Hosamane Sreedhara Swamy ,  Erra Koteswara Satya Vijaya Kumar ,  Manoj Maniram Singh Kushwaha ,  Sridevi Kota ,  Mythili Raman ,  Swati Dhananjay Tare ,  Sunil Kumar Deshmukh ,  Dietmar Schummer ,  Michael Kurz ,  Herbert Kogler

IPC分类号： C12N100

CPC分类号： C12R1/465 ,  C12P1/04 ,  Y10S435/822 ,  Y10S435/886

摘要： The present invention relates to a compound named Mumbaistatin, its pharmaceutically acceptable salts and derivatives, a process for its production, and its use as a pharmaceutical. Mumbaistatin is obtainable by cultivation of the microorganism HIL-008003 (DSM 11641). Mumbaistatin is a glucose-6-phosphate translocase inhibitor and can be used in the treatment of diabetes mellitus. The present invention further relates to a process for the production of Mumbaistatin, to the microorganism HIL-008003 (DSM 11641), to the use of Mumbaistatin and its pharmaceutically acceptable salts and derivatives as pharmaceuticals, in particular to their use in the treatment of diabetes mellitus, and to pharmaceutical compositions comprising Mumbaistatin or a pharmaceutically acceptable salt or derivative thereof.

摘要翻译： 本发明涉及一种名为孟巴斯丁（Mumbaistatin）的化合物及其药学上可接受的盐和衍生物，其生产方法及其作为药物的用途。 孟巴斯汀可通过培养微生物HIL-008003（DSM 11641）获得。 孟巴司他是一种葡萄糖-6-磷酸转位酶抑制剂，可用于治疗糖尿病。 本发明还涉及生产孟鲁司他汀对微生物HIL-008003（DSM11641）的使用，以使用孟巴斯妥及其药学上可接受的盐和衍生物作为药物，特别是其用于治疗糖尿病 以及包含孟巴斯妥坦或其药学上可接受的盐或衍生物的药物组合物。