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1.发明授权Mumbaistatin, a process for it's production and its use as a pharmaceutical 失效孟买斯他汀（Mumbaistatin），它是生产和作为药物使用的过程公开(公告)号：US06297043B1
公开(公告)日：2001-10-02
申请号：US09338601
申请日：1999-06-23
申请人： Nirogi Venkata Satya Ramakrishna , Keshavapura Hosamane Sreedhara Swamy , Erra Koteswara Satya Vijaya Kumar , Manoj Maniram Singh Kushwaha , Sridevi Kota , Mythili Raman , Swati Dhananjay Tare , Sunil Kumar Deshmukh , Dietmar Schummer , Michael Kurz , Herbert Kogler
发明人： Nirogi Venkata Satya Ramakrishna , Keshavapura Hosamane Sreedhara Swamy , Erra Koteswara Satya Vijaya Kumar , Manoj Maniram Singh Kushwaha , Sridevi Kota , Mythili Raman , Swati Dhananjay Tare , Sunil Kumar Deshmukh , Dietmar Schummer , Michael Kurz , Herbert Kogler
IPC分类号： C12N100
CPC分类号： C12R1/465 , C12P1/04 , Y10S435/822 , Y10S435/886
摘要： The present invention relates to a compound named Mumbaistatin, its pharmaceutically acceptable salts and derivatives, a process for its production, and its use as a pharmaceutical. Mumbaistatin is obtainable by cultivation of the microorganism HIL-008003 (DSM 11641). Mumbaistatin is a glucose-6-phosphate translocase inhibitor and can be used in the treatment of diabetes mellitus. The present invention further relates to a process for the production of Mumbaistatin, to the microorganism HIL-008003 (DSM 11641), to the use of Mumbaistatin and its pharmaceutically acceptable salts and derivatives as pharmaceuticals, in particular to their use in the treatment of diabetes mellitus, and to pharmaceutical compositions comprising Mumbaistatin or a pharmaceutically acceptable salt or derivative thereof.
摘要翻译： 本发明涉及一种名为孟巴斯丁（Mumbaistatin）的化合物及其药学上可接受的盐和衍生物，其生产方法及其作为药物的用途。 孟巴斯汀可通过培养微生物HIL-008003（DSM 11641）获得。 孟巴司他是一种葡萄糖-6-磷酸转位酶抑制剂，可用于治疗糖尿病。 本发明还涉及生产孟鲁司他汀对微生物HIL-008003（DSM11641）的使用，以使用孟巴斯妥及其药学上可接受的盐和衍生物作为药物，特别是其用于治疗糖尿病 以及包含孟巴斯妥坦或其药学上可接受的盐或衍生物的药物组合物。
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公开(公告)号：US08268775B2
公开(公告)日：2012-09-18
申请号：US12640273
申请日：2009-12-17
CPC分类号： C07D273/00 , C07K5/0808 , C12P17/00 , C12R1/01
摘要： The disclosure relates to compounds of the formula (I): wherein R1, R2, R3, and R4 are as defined in the disclosure, or a pharmaceutically acceptable salt thereof; which is formed by the microorganism ST 201196 (DSM 18870); the use thereof for the treatment and/or prophylaxis of fungal disorders; medicaments containing a compound of formula (I); processes for production thereof; and the microorganism ST 201196 (DSM 18870).
摘要翻译： 本公开涉及式（I）的化合物：其中R 1，R 2，R 3和R 4如本公开内容所定义，或其药学上可接受的盐; 其由微生物ST 201196（DSM 18870）形成; 其用于治疗和/或预防真菌病症的用途; 含有式（I）化合物的药物; 生产过程; 和微生物ST 201196（DSM 18870）。
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3.发明申请MACROLACTONE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND USE THEREOF FOR THE TREATMENT OF CANCER 审中-公开麦角酮衍生物，其生产方法及其用于治疗癌症的方法公开(公告)号：US20110306563A1
公开(公告)日：2011-12-15
申请号：US13139458
申请日：2009-12-10
CPC分类号： A61K31/395 , C07K5/0808
摘要： The present invention relates to the use of a compound of the formula (I), wherein X and Y independently of one another are OH, O—(C1-C6)-alkyl, NH2 or NH—(C1-C6)-alkyl, or X and Y together form a group —O— or wherein X and Y together form a further bond between the C atoms to which they are attached; R1 and R2 independently of one another are H, Cl or Br; R3 is H,(C1-C6)alkyl, C(═O)—(C1-C6)-alkyl or (C1-C6)-alkylene-NH—(C1-C6)-alkyl; R4 is H, (C1-C6)-alkyl or C(═O)—(C1-C6)-alkyl, and R5 is methyl or ethyl; or a physiologically tolerable salt of a compound of the formula (I), for the treatment and/or prophylaxis of cancer diseases, a pharmaceutical composition for the treatment and/or prophylaxis of cancer diseases comprising a compound of the formula (I), a compound of the formula (I) and a process for the preparation of the compound (I).
摘要翻译： 本发明涉及式（I）化合物的用途，其中X和Y彼此独立地为OH，O-（C 1 -C 6） - 烷基，NH 2或NH-（C 1 -C 6） - 烷基， 或X和Y一起形成基团-O-或其中X和Y一起在它们所连接的C原子之间形成另外的键; R1和R2彼此独立地是H，Cl或Br; R3是H，（C1-C6）烷基，C（= O） - （C1-C6） - 烷基或（C1-C6） - 亚烷基-NH-（C1-C6） - 烷基; R4是H，（C1-C6） - 烷基或C（= O） - （C1-C6） - 烷基，R5是甲基或乙基; 或式（I）化合物的生理上可耐受的盐，用于治疗和/或预防癌症疾病，用于治疗和/或预防癌症疾病的药物组合物，其包含式（I）化合物， 式（I）的化合物和化合物（I）的制备方法。
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公开(公告)号：US08841341B2
公开(公告)日：2014-09-23
申请号：US12675561
申请日：2008-09-05
IPC分类号： A61K31/335 , A61K8/02 , A61K8/18 , A61K31/365
CPC分类号： A61K31/365
摘要： The invention provides a compound termed Carolacton having the structure and derivatives thereof for medical use against biofilm formation by bacteria.
摘要翻译： 本发明提供了一种称为卡罗乳糖的化合物，其具有医疗用于细菌生物膜形成的结构和衍生物。
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公开(公告)号：US4997820A
公开(公告)日：1991-03-05
申请号：US405376
申请日：1989-09-08
摘要： Novel macrocyclic compounds of the formual I ##STR1## where the dotted line in the 9,10-position is a saturated bond or a double bond, alternatively, and R is hydrogen, methyl or certain acyl radicals, and R.sub.o is hydrogen, halogen, azido, thiol, hydroxyl or --OY, where Y is, among other radicals, an ether radical, a silyl group, a sulfonyl group, a sugar radical or a (thiol)acyl radical, and R being methyl if there is a double bond in the 9,10-position, have microbicidal properties for the control of phytopathogenic microorganisms. They can be employed in the customary formulation for the control of plant disease.
摘要翻译： 其中9,10位的虚线是饱和键或双键的式I（I）的新型大环化合物，或者R是氢，甲基或某些酰基，Ro是氢 卤素，叠氮基，硫醇，羟基或-OY，其中Y是醚基，甲硅烷基，磺酰基，糖基或（硫醇）酰基等基团，R是甲基，如果有 在9,10位的双键具有控制植物病原微生物的杀菌性。 它们可以用于控制植物病害的习惯制剂。
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公开(公告)号：US4940804A
公开(公告)日：1990-07-10
申请号：US405379
申请日：1989-09-08
IPC分类号： C07D493/08 , A01N43/90 , C07H19/01
摘要： Derived macrocyclic compounds of the formula I ##STR1## where R is hydrogen, methyl or certain acyl groups, the dotted line in the 9,10-position is a saturated bond or, in the event that R is methyl, is also a double bond, and X is a keto group, or a substituted or unsubstituted oxime, hydrazone or semicarbazone, represent effective microbicides for controlling plant diseases. They can be employed in the customary formulation as agrochemical agents.
摘要翻译： 衍生的式I（I）的大环化合物其中R是氢，甲基或某些酰基，9,10-位的虚线是饱和键，或者在R是甲基的情况下也是 双键，X是酮基，或取代或未取代的肟，腙或缩氨基脲代表用于防治植物病害的有效杀微生物剂。 它们可以作为农药的常规制剂使用。
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公开(公告)号：US20110034708A1
公开(公告)日：2011-02-10
申请号：US12675561
申请日：2008-09-05
IPC分类号： C07D313/00
CPC分类号： A61K31/365
摘要： The invention provides a compound termed Carolacton having the structure and derivatives thereof for medical use against biofilm formation by bacteria.
摘要翻译： 本发明提供了一种称为卡罗乳糖的化合物，其具有医疗用于细菌生物膜形成的结构和衍生物。
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公开(公告)号：US5026878A
公开(公告)日：1991-06-25
申请号：US602825
申请日：1990-10-25
IPC分类号： C07D493/08 , A01N43/90 , C07H19/01
摘要： Derived macrocyclic compounds of the formula I ##STR1## where R is hydrogen, methyl or certain acyl groups, the dotted line in the 9,10-position is a saturated bond or, in the event that R is methyl, is also a double bond, and X is a keto group, or a substituted or unsubstituted oxime, hydrazone or semicarbazone, represent effective microbicides for controlling plant diseases. They can be employed in the customary formulation as agrochemical agents.
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公开(公告)号：US4987149A
公开(公告)日：1991-01-22
申请号：US485120
申请日：1990-02-23
IPC分类号： C07D493/08 , A01N43/90 , C07H19/01
摘要： Derived macrocyclic compounds of the formula I ##STR1## where R is hydrogen, methyl or certain acyl groups, the dotted line in the 9,10-position is a saturated bond or, in the event that R is methyl, is also a double bond, and X is a keto group, or a substituted or unsubstituted oxime, hydrazone or semicarbazone, represent effective microbicides for controlling plant diseases. They can be employed in the customary formulation as agrochemical agents.
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